Effects of liver transplantation on diabetes in cirrhosis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study assesses insulin secretion and sensitivity in patients with liver cirrhosis who are undergoing orthotopic liver transplantation (OLT). It utilizes mathematical modeling based on oral glucose tolerance tests conducted before and at various time points after the transplantation. The study aims to understand how OLT affects glucose metabolism and the potential development or persistence of diabetes-related abnormalities over a 10-year follow-up period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Subjects with end-stage liver cirrhosis in waiting list for orthotopic liver transplantation at the Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Milan, Italy

Exclusion Criteria:

* Known diabetes
* Cystic fibrosis
* Pregnancy

Where it's running

• Endocrinology and Diabetes Unit, Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico
  Milan, Mi, Italy Recruiting

Study contacts

• Principal investigator: Emanuela Orsi, MD — Endocrinology and Diabetes Unit, Fondazione IRCCS Cà Granda - Ospedale Maggiore Policlinico, Milan, Italy
• Study coordinator: Emanuela Orsi, MD
• Email: e.orsi@policlinico.mi.it
• Phone: +390255034590

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.