Liver cirrhosis clinical centers network
Liver Cirrhosis Network: Clinical Research Centers
This project follows people with cirrhosis from causes like fatty liver disease, alcohol-related liver disease, and HIV to collect medical data and samples that help spot who is at higher risk for liver complications.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11169754 on NIH RePORTER |
What this research studies
If you join, the network will enroll people with compensated cirrhosis from different causes and follow them over time with regular clinic visits, blood draws, imaging and other tests. The project will collect and store biological samples and standard clinical data at multiple centers across the U.S., with outcomes like liver events and death tracked by a central adjudication process. Researchers will test non-invasive tools such as spleen stiffness measurements and blood biomarkers (for example PRO-C3 and the ELF test) to see which best predict problems. This is an observational effort (no experimental drugs in the core protocol) designed to support future mechanistic and treatment trials that could enroll participants from the network.
Who could benefit from this research
Good fit: Adults with compensated liver cirrhosis from NASH, alcohol-related liver disease, or those living with HIV who can attend follow-up visits and provide blood samples are ideal candidates.
Not a fit: People with decompensated or end-stage liver disease (for example those already listed for transplant) or those unable to attend study visits are less likely to benefit from this observational network.
Why it matters
Potential benefit: If successful, the work could lead to better non-invasive tests and earlier interventions that prevent liver complications and save lives.
How similar studies have performed: Smaller studies have shown promise for biomarkers and imaging to predict liver outcomes, but this large, multi-center, etiology-agnostic network is broader and less tested.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Sanyal, Arun J — Virginia Commonwealth University
- Study coordinator: Sanyal, Arun J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.