Managing blood clotting in patients with liver cirrhosis undergoing TIPS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and effectiveness of a thrombelastography-guided algorithm for managing coagulation status in patients with liver cirrhosis who are undergoing a transjugular intrahepatic portosystemic shunt (TIPS) procedure. The TIPS procedure is used to treat complications of portal hypertension in cirrhotic patients, but it carries risks such as bleeding and other complications due to coagulation disturbances. By optimizing coagulation management before the procedure, the study aims to reduce these risks and improve patient outcomes. Participants will be monitored for complications and overall health following the intervention.

Why it matters

Who can join: the full rules

inclusion criteria

* Liver cirrhosis
* \>18 years
* Indication for TIPS implantation
* Ability to sign informed consent exclusion criteria
* Contraindications against TIPS implantation
* Hepatocellular carcinoma BCLC D
* Ongoing bleeding
* pre-existing anticoagulant therapy at time of inclusion
* administration of blood products within 1 week prior to the enrolment
* Other malignancies that lead to an impaired 90-day survival
* Inherit blood clotting disorders
* Hepatic encephalopathy grade 3 or 4
* any other condition or circumstance, which, in the opinion of the investigator, would affect the patient's ability to participate in the protocol

Where it's running

• Department of Internal Medicine, Medical University of Graz
  Graz, Austria Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.