Condition

Liver Transplantation clinical trials and research

• 33Clinical trials
• 48NIH research projects
• 22Countries

Newest Liver Transplantation clinical trials

All recruiting trials (33)

• Everolimus-based calcineurin-free immunosuppression one year after liver transplant

  This trial tests whether switching to or using everolimus with reduced calcineurin inhibitors after year one post-liver transplant can protect kidney function while maintaining graft health in adults at low rejection risk.

  Recruiting Phase 3 Hannover Medical School · Heidelberg, Baden-Wurttemberg and 15 other locations · NCT07739914

• Sleep quality and its determinants during the liver transplant pathway

  This study tests how sleep quality changes from before liver transplantation to six months after, in adults on the transplant waitlist at a single hospital.

  Recruiting Hospices Civils de Lyon · Lyon · NCT07674355

• Preoperative CIMT and Intraoperative Hemodynamics in Liver Transplant

  This study looks at whether a higher carotid IMT measured before surgery is linked to more unstable blood pressure during liver transplant.

  Recruiting Dicle University · Diyarbakır · NCT07660679

• Reference framework for outcomes after machine-preserved liver transplantation in Europe

  This study tests how liver transplants that use machine perfusion perform in real-world practice, to see how different perfusion methods relate to outcomes for adults in Europe.

  Recruiting at 4 sites University Medical Center Groningen · Innsbruck and 37 other locations · NCT07585890

• Even protein distribution plus exercise for people awaiting liver transplant

  This trial tests whether spreading daily protein evenly and combining it with a 12-week exercise program improves nutrition, muscle mass, and function in people waiting for a liver transplant compared with uneven protein timing or usual advice.

  Recruiting at 2 sites Agricultural University of Athens · Athens, Attica and 1 other locations · NCT07561138

• Preoperative Carbohydrate Loading Before Liver Transplant

  This study tests whether drinking a carbohydrate beverage before anesthesia helps liver transplant patients recover faster.

  Recruiting Medical University of Warsaw · Warsaw · NCT07519057

• Frailty, Nutrition, and Recovery in People Waiting for a Liver Transplant

  This project will test whether measures of frailty, muscle loss, nutrition, and psychological health can predict outcomes for adults (18–65) on the liver transplant waiting list in Turkey.

  Recruiting Izmir Bakircay University · Izmir · NCT07414095

• Comparing terlipressin and somatostatin to lower portal pressure during living-donor liver transplant

  This trial tests whether terlipressin or somatostatin better lowers portal pressure and reduces bleeding and transfusion needs in people having a right-lobe living-donor liver transplant.

  Recruiting Istanbul Medipol University Hospital · Istanbul, Bagcilar · NCT07304466

• Train the immune system to accept a living-donor liver so you may stop lifelong anti-rejection drugs

  This test gives donor stem cells plus a short conditioning treatment to people with HLA-matched living-donor liver transplants to see if they can safely stop long-term immunosuppressive drugs.

  Recruiting Phase 1/2 University of California, Los Angeles · Los Angeles, California · NCT07269041

• Tranexamic acid to reduce bleeding in adult liver transplant

  This will test whether giving tranexamic acid during adult liver transplant reduces blood loss in the first 24 hours and does not increase clotting in the first week.

  Recruiting RenJi Hospital · Shanghai, Shanghai Municipality · NCT07157631

• Spinal (intrathecal) morphine versus bi-level erector spinae plane block for pain after living liver donation

  This will try spinal (intrathecal) morphine versus a bi-level erector spinae plane block to reduce pain and opioid use in living liver donors after hepatectomy.

  Recruiting Ankara Etlik City Hospital · Altındağ, Ankara · NCT07123740

• Comparing two methods of monitoring heart function during liver transplantation

  This study is testing two different ways to monitor heart function during liver transplant surgery to see which method gives better information for doctors.

  Recruiting Hospices Civils de Lyon · France, Lyon · NCT06899867

• Normothermic machine perfusion to re-evaluate declined donor livers and shorten transplant waiting time

  This trial tests whether keeping declined donor livers functioning on a normothermic perfusion machine can make more livers usable and help adults on the transplant waiting list (ReMELD‑Na ≤21) get transplanted sooner.

  Recruiting at 10 sites Charite University, Berlin, Germany · Hamburg, Free and Hanseatic City of Hamburg and 9 other locations · NCT06874296

• Investigating liver and pancreas surgery followed by transplantation for advanced cholangiocarcinoma

  This study is testing a new surgery method for patients with advanced bile duct cancer to see if removing the liver and pancreas together, followed by a liver transplant, can help them live longer.

  Recruiting Oslo University Hospital · Oslo · NCT06850753

• Electronic archive for treating severe organ failure and liver transplantation

  This study looks at medical records of patients with severe liver failure to see how well different treatments work and improve liver transplant care over the next 10 years.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06781502

• Evaluating eye characteristics to improve liver transplant outcomes

  This study is testing whether eye features can help doctors better understand and improve health outcomes for people with chronic liver disease before and after they get a liver transplant.

  Recruiting Zhongshan Ophthalmic Center, Sun Yat-sen University · Guangzhou, Guangdong · NCT06756009

• Using Quantra bedside clot testing to guide blood transfusions during liver transplant

  This will test whether using Quantra bedside clot testing during liver transplants can reduce bleeding and the need for blood transfusions in adults with end-stage liver disease.

  Recruiting University Hospital, Toulouse · Toulouse · NCT06749405

• HOPE perfusion to reduce liver cancer coming back after transplant

  This trial tests whether treating donor livers with hypothermic oxygenated perfusion (HOPE) before transplant helps people with hepatocellular carcinoma (HCC) have less cancer recurrence and better survival.

  Recruiting at 10 sites Phase 4 Clarunis - Universitäres Bauchzentrum Basel · New York, New York and 36 other locations · NCT06717919

• Comparing hemodynamic monitoring techniques during liver transplantation

  This study is testing two different ways to monitor blood flow during liver transplant surgery to see if one method can help reduce low blood pressure during the operation.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Emilia-Romagna · NCT06703008

• Effect of Albumin on Kidney Function After Liver Transplant

  This study is testing if giving extra albumin to liver transplant patients can help prevent kidney problems after their surgery.

  Recruiting at 8 sites Phase 4 Rennes University Hospital · Chambray-lès-Tours and 7 other locations · NCT06535945

• Intervention for liver transplant recipients with alcohol use disorder

  This study tests a new support program for liver transplant patients with a history of alcohol problems to see if it helps them avoid drinking again and live longer.

  Recruiting at 16 sites University Hospital, Montpellier · Besançon and 15 other locations · NCT06472973

• Improving liver transplant outcomes using machine perfusion techniques

  This study is testing different machine methods to see if they can better preserve livers from high-risk donors who died from cardiac arrest, with the goal of improving liver transplant success for patients.

  Recruiting at 2 sites King's College Hospital NHS Trust · Birmingham and 1 other locations · NCT06371924

• Once-daily tacrolimus regimens during the first year after liver transplant

  This will try once-daily tacrolimus with mycophenolate to see if simpler dosing helps people take their medicines and protects the transplanted liver during the first year after a liver transplant.

  Recruiting at 17 sites Phase 4 University Hospital, Limoges · Besançon and 17 other locations · NCT06354179

• Home-based exercise program for liver transplant recipients

  This study is testing whether different levels of exercise at home can help people who have recently had a liver transplant feel better and improve their health over six months.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06302205

• Evaluating heart health factors after liver transplantation

  This study is testing if advanced heart imaging techniques can help doctors better understand and manage heart risks in patients getting a liver transplant.

  Recruiting at 2 sites Sun Yat-sen University · Guangzhou, Guangdong and 1 other locations · NCT06290154

• Using serum glycomics to predict liver cancer recurrence after transplantation

  This study is testing whether changes in certain sugars in the blood can help predict if liver cancer will come back in patients who have had a liver transplant.

  Recruiting University Hospital, Ghent · Ghent · NCT05866783

• Assessing long-term outcomes of donor livers preserved with machine perfusion

  This study looks at whether using a special machine to keep donor livers healthy for longer before transplant can help people have better long-term outcomes after their liver surgery.

  Recruiting University Medical Center Groningen · Groningen · NCT05680246

• Immunotherapy for Liver Cancer Patients Before Transplantation

  This study is testing if a new immunotherapy treatment can help liver cancer patients shrink their tumors enough to qualify for a liver transplant.

  Recruiting Phase 2 Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT05475613

• Modeling liver blood flow during surgery

  This study is testing a new way to predict blood flow changes during liver surgeries to help doctors choose the right patients and reduce the risk of liver failure after surgery.

  Recruiting Assistance Publique - Hôpitaux de Paris · Villejuif, Val de Marne · NCT05339984

• Exploring kidney health in patients after liver transplantation

  This study looks at how kidney health changes over time in people who have had a liver transplant and are experiencing kidney problems, to see what factors might affect their condition.

  Recruiting RenJi Hospital · Shanghai and 1 other locations · NCT05326399

• Comparing two formulations of tacrolimus for liver transplant patients

  This study is testing whether a new extended-release version of tacrolimus causes fewer and less severe tremors in liver transplant patients compared to the standard immediate-release version.

  Recruiting Phase 4 University of British Columbia · Vancouver, British Columbia · NCT05089604

• Effects of a Mediterranean diet after liver transplantation

  This study tests if following a Mediterranean diet can help people who have had a liver transplant maintain a healthy weight and improve their heart health over a year.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT04672863

• Evaluating external biliary drainage in living donor liver transplantation

  This study is testing whether using external biliary drainage during living donor liver transplants can help reduce complications compared to the standard method.

  Recruiting Seoul National University Hospital · Seoul · NCT04622540

NIH-funded research (newest 40 of 48)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Targeting a specific CD38 form to protect livers from injury after transplant

  A new approach tests a selective drug to protect donor livers from injury during transplant, potentially increasing usable organs and improving transplant outcomes.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11465898

• Regulatory dendritic cell therapy to reduce immunosuppressive drugs after liver transplant

  A new approach using donor-derived regulatory dendritic cells is being tested to help adults who receive a liver transplant live without relying on traditional immunosuppressive drugs.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11448171

• HOPE liver transplant: reducing infections and cancer risk for HIV-positive recipients

  This grant aims to better understand why HIV-positive liver transplant recipients face higher infection and cancer risks and to improve safety and outcomes for these patients.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11421494

• Early liver transplant decisions for severe alcohol-related liver disease

  A large study follows adults with severe alcohol-related liver disease to understand how to best select and manage patients for early liver transplantation.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11418080

• Early Liver Transplant for Severe Alcoholic Hepatitis

  A hospital-based program is studying whether offering an early liver transplant to patients with severe alcoholic hepatitis can save lives when standard medical treatment fails.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11413514

• Early liver transplant for severe alcoholic hepatitis (SAH) to save lives

  A Johns Hopkins program is testing whether giving an early liver transplant to patients with severe alcoholic hepatitis who can’t be helped by standard treatments can save lives and reduce relapse risk.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11413494

• ACCELERATE-PACE: Early Liver Transplantation for Alcohol-Related Liver Disease

  A large study follows adults with severe alcohol-related liver disease to understand who can benefit from early liver transplantation and how best to manage care.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11408437

• Integrated care to improve outcomes after early liver transplant for alcohol-related liver disease

  A multi-center study tests how coordinated medical and psychosocial care around early liver transplant for people with alcohol-related liver disease can improve their health and recovery.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11402257

• INTEGRATE: Improving Biopsychosocial Care for Early Liver Transplant in Alcohol-Related Liver Disease

  A multi-center study aims to improve how early liver transplant decisions are made for people with alcohol-related liver disease by focusing on medical, behavioral, and social factors.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11402223

• Integrated care to improve liver transplant outcomes for alcohol-associated liver disease

  A multi-center study will see how integrating alcohol-use treatment with liver transplant care affects biopsychosocial outcomes for people with alcohol-related liver disease who are being considered for early liver transplantation.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11398268

• ACCELERATE-PACE: Early Liver Transplantation for Alcohol-Related Liver Disease

  A multi-site, long-term study follows adults with severe alcohol-related liver disease to understand who benefits most from early liver transplantation and how best to manage care across the transplant process.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11393832

• Frailty and outcomes after liver transplant in acutely ill patients

  This grant studies how frailty affects recovery and survival for people with cirrhosis who undergo liver transplantation during an acute hospital stay.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11379527

• Survivorship-based model to improve liver transplant waiting lists

  A data-driven model using AI will help allocate liver transplants more fairly and effectively, aiming to reduce deaths on the waitlist and improve long-term outcomes for patients with end-stage liver disease.

  NIH research University of Florida · Gainesville, United States · NIH-11365694

• Preventing heart problems after liver transplant in people with high blood pressure

  This grant funds a study to understand how best to manage blood pressure in liver transplant patients to reduce heart-related complications.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11345499

• Cognitive impairment after liver transplant in people with cirrhosis

  This project looks at how brain function may change after liver transplant in people with cirrhosis and how it relates to everyday daily living.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11323202

• A real-time light scan to check if a donated liver is healthy enough for transplant

  This work uses a special light-based scan during organ preservation to quickly tell transplant teams whether a donated liver is likely to work well for someone on the liver transplant waitlist.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11286824

• Safer liver transplants from HIV-positive donors

  This project looks at whether liver transplants from HIV-positive donors are safe for people living with HIV and how to lower infections and virus-related cancers.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11258257

• Integrated care to improve biopsychosocial outcomes after early liver transplant for alcohol-related liver disease

  The team tests whether combining alcohol-use disorder treatment with transplant care helps people with alcohol-related liver disease who receive early liver transplants stay sober and do better after surgery.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11169937

• Improving heart health in liver transplant patients with high blood pressure

  This study is looking at the best ways to help liver transplant patients manage their high blood pressure to keep their hearts healthy, and it will track their progress over two years to find the most effective treatments just for them.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11164625

• Early liver transplant for severe alcohol-related liver disease

  This project follows people with severe alcohol-related liver disease who are being considered for liver transplants before six months of sobriety to learn who does best and why.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11161487

• Early liver transplant evaluation for people with severe alcohol-related liver disease

  This project follows adults with severe alcohol-related liver disease to learn which patients benefit most from getting a liver transplant sooner than the usual six-month sobriety period.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11146343

• Early liver transplantation for severe alcohol-related liver disease

  This project follows adults with severe alcohol-related liver disease who are being considered for liver transplants before six months of sobriety to learn which selection and care practices lead to the best outcomes.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11145186

• Integrated care to improve outcomes after early liver transplant for alcohol-related liver disease

  Looking at whether coordinated liver and addiction care helps people with alcohol-related liver disease who receive early liver transplants.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11144380

• Understanding cognitive impairment in liver transplant patients

  This study is looking at how liver transplant patients might struggle with thinking and memory problems, like those seen in Alzheimer's, to help doctors better support their brain health and recovery after surgery.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11142600

• Early liver transplant options for severe alcohol-related liver disease

  This project follows adults with severe alcohol-related liver disease who are being considered for early liver transplant to find which selection and care approaches help patients do best.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11141790

• Integrated care for early liver transplant in alcohol-related liver disease

  This project tests whether coordinated addiction and medical care helps people with alcohol-related liver disease who receive early liver transplants stay sober and have better health and quality of life after transplant.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11137784

• Improving liver transplantation outcomes using advanced preservation techniques

  This study is looking at a new way to keep liver donations healthy longer, especially from older donors or those with fatty livers, to help patients who need liver transplants recover better and have fewer problems after surgery.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11123341

• Early liver transplant for severe alcoholic hepatitis — animal work

  This project uses animal models to learn how chronic or recent heavy drinking affects liver transplant results for people with severe alcoholic hepatitis.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11101272

• Early liver transplant for severe alcoholic hepatitis

  This project offers early liver transplants to people with life-threatening severe alcoholic hepatitis who are too sick to wait the usual six months of sobriety.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11101251

• Early liver transplant for severe alcoholic hepatitis

  This work looks at using earlier liver transplants to save people with life-threatening severe alcoholic hepatitis who do not get better with medical treatment.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11101244

• Measuring the viability of liver transplants using advanced spectroscopy techniques

  This study is looking at a new way to quickly check if a liver is healthy enough for transplant, especially for those that might be a little damaged, so that more people in need of a liver can get one.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11051898

• Understanding recovery experiences after liver transplantation

  This study is looking at how people feel and cope after getting a liver transplant, focusing on their physical and emotional challenges, and it aims to find ways to improve support and care for them during their recovery.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11032672

• Investigating the gut microbiome's role in antibiotic-resistant infections after lung or liver transplants

  This study is looking at how the bacteria in your gut might affect the presence of tough-to-treat infections in people who have had lung or liver transplants, with the goal of finding ways to better manage antibiotic resistance for these patients.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11006352

• Improving fairness in kidney and liver organ allocation

  This study is working on a new way to fairly distribute kidney and liver transplants so that everyone, no matter where they live or their background, has an equal chance of receiving a life-saving organ.

  NIH research New York University School of Medicine · New York, United States · NIH-10991815

• Creating a program to help liver transplant patients recover from alcohol use disorder

  This study is testing a new support program for people who have received a liver transplant and are dealing with alcohol use issues, helping them stay on track with their recovery through community health workers.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10912818

• Evaluating early liver transplantation for patients with severe alcohol-related liver disease

  This study is looking at how early liver transplants can help people with serious liver problems caused by alcohol, and it aims to find the best ways to choose patients for these transplants and support their recovery, so they can get the care they need.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10909244

• Evaluating early liver transplantation for patients with severe alcohol-related liver disease

  This study is looking at how early liver transplants can help people with serious liver problems caused by alcohol, and it aims to find the best ways to choose patients who might benefit from a transplant, especially focusing on how staying sober can improve liver health.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-10909188

• Improving care for patients with alcohol-related liver disease undergoing liver transplantation

  This study is looking at how better teamwork among doctors and healthcare providers can help people with alcohol-related liver disease who are getting a liver transplant, by understanding what influences their chances of getting referred for the transplant and how different personal and social factors can affect their

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10904906

• Evaluating early liver transplantation for patients with severe alcohol-related liver disease

  This study is looking at how early liver transplants can help people with severe liver problems caused by alcohol, and it aims to find the best ways to choose patients for the transplant and support their recovery, especially focusing on how quitting alcohol can improve their liver health.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-10895509

• Evaluating integrated care to improve outcomes for liver transplant patients with alcohol-related liver disease

  This study is looking at how combined medical and support care can help people with alcohol-related liver disease who are getting a liver transplant, focusing on what helps them get referred for the transplant and how they can do better afterward.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10894076

Related topics

Quick answers

How many Liver Transplantation clinical trials are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in France (9 trials), China (5 trials), Italy (4 trials), Germany (4 trials), Belgium (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 3: 1, Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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