Developing and testing the Liver Cirrhosis Cognitive Decline Scale (LiCCoS)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational, cross-sectional project aims to create and psychometrically validate a patient-reported instrument (LiCCoS) for cognitive difficulties linked to liver cirrhosis. Investigators will generate items grounded in attention, working memory, executive function, and psychomotor theory, then refine the questionnaire using responses from adults with clinically confirmed cirrhosis. Participants will complete the LiCCoS along with standard cognitive measures and clinical data to test reliability, validity, and item performance. The goal is a short, easy-to-use tool suitable for routine clinical and research settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-75 years.
* Documented clinical diagnosis of liver cirrhosis based on imaging, histology, or validated clinical criteria.
* Able to read and understand the language of the cognitive tests.
* Willing and able to provide written informed consent.

Exclusion Criteria:

* Age \<18 or \>75 years
* Known case of Overt Hepatic Encephalopathy defined as Grade II or higher on the West Haven criteria \[25\].
* Use of central nervous system depressants, anticholinergics, or psychotropics initiated or changed within the past 4 weeks.
* Known case of Severe uncorrected visual or hearing impairment limiting ability to complete cognitive testing.
* Known case of Any neurological and psychological disorders, substance use disorder and sleep disorders.
* Known case of Severe systemic illness (e.g., end-stage renal disease, decompensated heart failure) that may independently impair cognition or limit participation.

Where it's running

• Maharishi Markandeshwar (Deemed to be University)
  Ambāla, Haryana, India Recruiting

Study contacts

• Study coordinator: Rajat Rana, PhD
• Email: rajatrana91@gmail.com
• Phone: 601127873697

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.