Liver Cirrhosis Network: Centers for Clinical Research
Official title: Liver Cirrhosis Network: Clinical Research Centers
Funded at Virginia Commonwealth University · NIH-11591517 · Data updated 2026-11-12
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | September 13, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $341,435 |
| NIH project number | 5U01DK130134-06 |
| Project ID | NIH-11591517 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with compensated cirrhosis from various etiologies, including NASH, alcohol-related liver disease, with or without HIV, who can participate in long-term follow-up.
✕Less likely to help
Patients without cirrhosis or with decompensated disease at enrollment may not directly benefit from this study.
What this research studies
This project enrolls patients with various types of cirrhosis and follows them over time, collecting clinical data and biological samples. Researchers will test new tools like spleen-stiffness measurements and circulating biomarkers to see how well they predict progression to complications or death. The study aims to create a foundation for future mechanistic and therapeutic research by standardizing data collection and outcome adjudication across sites. Participants may contribute blood, tissue, and imaging data to help build a clearer picture of cirrhosis progression. The work is designed to inform non-invasive risk stratification and future targeted treatments.
Why it matters
Potential benefit: If successful, patients with cirrhosis could receive better risk prediction and monitoring, leading to earlier interventions and improved outcomes.
How similar studies have gone: Previous observational efforts have shown promise in identifying biomarkers and imaging tools that correlate with disease progression; this study builds on those findings with a broader, standardized approach.
Where this research is happening
-
Virginia Commonwealth University
Richmond, United States Active
Researchers
- Principal investigator: Sanyal, Arun J — Virginia Commonwealth University
- Study coordinator: Sanyal, Arun J
Related research
Other NIH-funded projects on the same topics.
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial
This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.
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First-in-class treatment for liver cirrhosis with portal hypertension
A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.
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Liver cirrhosis network coordinating treatments and patient data
This program brings hospitals together to run and organize tests of treatments and care approaches for people living with liver cirrhosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.