Using Orphenadrine to Treat Muscle Cramps in Patients with Cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the efficacy of orphenadrine, an anticholinergic medication, in alleviating muscle cramps experienced by patients with liver cirrhosis. Muscle cramps are a common and debilitating symptom in this population, and the study aims to determine if orphenadrine can improve their quality of life. Participants will be randomly assigned to receive either orphenadrine or a placebo, with the frequency and severity of muscle cramps being monitored throughout the trial. The study seeks to clarify the potential benefits of this medication in a population that has limited treatment options for muscle cramps.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Cirrhosis
* Muscle cramps( ≥3 cramps per week )

Exclusion Criteria:

* • Allergy to orphenadrine

  * Renal impairment
  * Pregnant and lactating women
  * Peripheral vascular disease
  * Peripheral neuropathy
  * Medications as calcium channel blockers, conjugated estrogens and naproxen. Glaucoma Prostatic enlargement

Where it's running

• Tanta university hospital
  Tanta, Egypt Recruiting

Study contacts

• Principal investigator: Asem A Elfert, Professor — Tuh
• Study coordinator: Sherief M Abd-Elsalam, lecturer
• Email: Sherif_tropical@yahoo.com
• Phone: 01000058842

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.