Condition

Acute-On-Chronic Liver Failure clinical trials and research

• 17Clinical trials
• 29Countries

Newest Acute-On-Chronic Liver Failure clinical trials

All recruiting trials (17)

• Factors that affect how well mesenchymal stromal cell (MSC) therapy works for hepatitis B–related acute-on-chronic liver failure.

  This project will look back at people with hepatitis B–related ACLF who received MSC infusions to see which factors affect whether the treatment helps.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT07198854

• AS1501 in ACLF: a two-stage dose study in adults with acute-on-chronic liver failure

  This Phase II study tests AS1501 given by injection in adults with early ACLF to see if it’s safe and tolerable and to guide dosing.

  Recruiting Phase 2 Shenzhen Third People's Hospital · Shenzhen, Guangdong · NCT06916585

• TAK-242 and G-CSF in ACLF: a new treatment approach for adults with acute-on-chronic liver failure

  This trial tests whether adding TAK-242, with or without G-CSF, to standard ACLF care helps patients with severe alcoholic hepatitis and ACLF.

  Recruiting Phase 2 Yaqrit Ltd · London, Greater London · NCT06890039

• Using different ROTEM cut-offs to guide blood transfusions before procedures in cirrhosis and ACLF

  This will test whether using relaxed ROTEM cut-offs to decide on blood transfusions reduces the number of transfusions without raising bleeding risk for people with cirrhosis or ACLF and severe coagulopathy who need invasive procedures.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT06831565

• Ceftazidime-avibactam vs high-dose meropenem for ACLF patients with hospital-acquired infections

  This trial tests whether ceftazidime-avibactam can better treat infections in ACLF patients than high-dose meropenem given in extended infusions, aiming to spare carbapenems if possible.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi, National Capital Territory of Delhi · NCT06818565

• Evaluating a new treatment for liver failure and sepsis

  This study is testing a new treatment for people with liver failure and sepsis to see if it can help them survive and improve their organ function.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT06562803

• Using CytoSorb device for patients with acute on chronic liver failure

  This study tests if using the CytoSorb device can help lower bilirubin and ammonia levels and improve muscle strength in patients with severe liver failure.

  Recruiting University Hospital, Antwerp · Edegem, Antwerp · NCT06079021

• Transplanting stem cells from umbilical cords to treat liver failure

  This study is testing if transplanting stem cells from umbilical cords can help people with severe liver failure feel better and improve their health.

  Recruiting Phase 1/2 Beijing 302 Hospital · Beijing, Beijing Municipality · NCT05985863

• Micro‑encapsulated hepatocyte transplant into the abdominal cavity for adults with liver failure

  This trial will try a single dose of micro‑encapsulated human hepatocytes placed into the abdominal cavity to see if it is safe and helps adults with chronic or acute‑on‑chronic liver failure.

  Recruiting Phase 1 RenJi Hospital · Shanghai · NCT05727722

• F573 injection for treating liver injury and failure

  This study is testing if an injection called F573 can help people with liver injury or chronic hepatitis B feel better and recover.

  Recruiting at 10 sites Phase 2 Beijing Continent Pharmaceutical Co, Ltd. · Beijing, Beijing Municipality and 9 other locations · NCT05689645

• Registry for monitoring CytoSorb device use in critically ill patients

  This study is collecting information on how the CytoSorb device helps critically ill patients to improve care for conditions like septic shock and acute respiratory distress syndrome.

  Recruiting at 24 sites CytoSorbents, Inc · Klagenfurt and 27 other locations · NCT05146336

• Effects of a new liver support system in patients with acute-on-chronic liver failure

  This study tests whether a new liver support system can help patients with acute-on-chronic liver failure recover better and live longer by cleaning their blood.

  Recruiting Chulalongkorn University · Bangkok · NCT05030571

• Liver transplantation outcomes for patients with severe liver failure

  This study is testing how well liver transplants work for people with severe liver failure compared to those with advanced cirrhosis to see which group has better survival rates and quality of life after the transplant.

  Recruiting at 69 sites European Foundation for Study of Chronic Liver Failure · Los Angeles, California and 105 other locations · NCT04613921

• Combining DPMAS and Low Volume Plasma Exchange for Hepatitis B Related Liver Failure

  This study is testing a new treatment combining a special blood filtering system and plasma exchange to see if it helps people with liver failure caused by hepatitis B feel better and improve their health.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT04597164

• Predicting liver failure after surgery in patients with chronic liver disease

  This study is trying to find out what causes liver failure after surgery in people with chronic liver disease to help doctors better predict risks for their patients.

  Recruiting University Hospital, Bonn · Bonn · NCT04578301

• Long-term outcomes for patients recovering from hepatitis B related liver failure

  This study looks at the long-term health and recovery of people who have survived liver failure caused by hepatitis B to see how they are doing over time.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT04310787

• Treatment of Hepatitis B Related Acute-On-Chronic Liver Failure with Nucleotide/Nucleoside Analogues

  This study is testing if three antiviral medications can help people with hepatitis B-related liver failure feel better and improve their chances of recovery.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT03920618

Related topics

Quick answers

How many Acute-On-Chronic Liver Failure clinical trials are recruiting right now?

17, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 29 countries. The most sites are in China (9 trials), India (3 trials), Germany (3 trials), Belgium (2 trials), Austria (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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