Using spleen size to help detect gastroesophageal varices in compensated cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective cross-sectional study that compares non-invasive ultrasound measurements of spleen thickness and spleen diameter to the invasive endoscopy results for detecting gastroesophageal varices and high-risk varices in patients with compensated cirrhosis. Researchers collected demographic, etiologic, and laboratory data along with imaging and endoscopy results to evaluate diagnostic performance. The analysis focuses on how well spleen size correlates with variceal presence and severity, potentially offering a non-invasive screening option. The study leverages data from patient records reviewed by senior infectious diseases and ultrasound physicians, with strict inclusion and exclusion criteria to define a stable compensated cirrhosis population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥18 years;
2. compensated cirrhosis;

Exclusion Criteria:

1. history of hepatic decompensation, such as ascites, EVB, and hepatic encephalopathy;
2. non-cirrhotic portal hypertension;
3. digestive system malignancies such as hepatocellular carcinoma, pancreatic carcinoma, or other malignant tumors infiltrating the digestive system;
4. acute liver disease, or serum total bilirubin ≥ 100 μmol/L;
5. history of splenectomy;
6. acute or chronic portal vein thrombosis;
7. pregnancy;
8. concomitant HIV infection;
9. prior TIPS, endoscopic variceal ligation (EVL), or endoscopic injection sclerotherapy (EIS);
10. receipt of non-selective beta-blockers (NSBBs) or diuretics within 3 months before EGD or abdominal ultrasonography;
11. persistent drug abuse other than alcohol;
12. an interval of more than 6 months between abdominal ultrasonography and EGD, or the absence of results from either examination.

Where it's running

• the Fifth Affiliated Hospital, Sun Yat-sen University
  Zhuhai, Guangdong, China Recruiting

Study contacts

• Study coordinator: Xi Liu
• Email: liuxi26@mail.sysu.edu.cn
• Phone: 15992670630

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.