Condition

Liver Transplant clinical trials and research

• 41Clinical trials
• 38NIH research projects
• 32Countries

Newest Liver Transplant clinical trials

All recruiting trials (41)

• Expanding HIV-positive donor livers for HIV-positive recipients

  This study tests whether liver transplants from HIV-positive donors to HIV-positive recipients are safe regarding opportunistic infections and cancer.

  Recruiting at 2 sites National Institute of Allergy and Infectious Diseases (NIAID) · Baltimore, Maryland and 1 other locations · NCT07778459

• Magnetic Resonance Cholangiopancreatography to help living liver donors and their recipients

  This study tests whether preoperative MRCP imaging can help select living liver donors and reduce biliary complications in recipients.

  Recruiting Institute of Liver and Biliary Sciences, India · New Delhi · NCT07715500

• Reducing Immunosuppression by 50% in Young Liver Transplant Recipients

  This study tests whether cutting the immunosuppressive medicine by half in children with liver transplants is safe and effective.

  Recruiting at 7 sites Phase 2 National Institute of Allergy and Infectious Diseases (NIAID) · San Francisco, California and 10 other locations · NCT07549503

• Preoperative Carbohydrate Loading Before Liver Transplant

  This study tests whether drinking a carbohydrate beverage before anesthesia helps liver transplant patients recover faster.

  Recruiting Medical University of Warsaw · Warsaw · NCT07519057

• Doctor counseling plus smartphone apps to support healthy eating and activity after liver or kidney transplant

  This program tries whether doctor-delivered lifestyle counseling combined with two smartphone apps can help people aged 60 and older who had a liver or kidney transplant eat healthier and be more active.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, BO · NCT07305012

• Long-term health of children born to mothers who had a solid organ transplant

  This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.

  Recruiting University Medical Center Groningen · Groningen, Provincie Groningen · NCT07291258

• Darbepoetin to lower blood transfusions for people awaiting liver transplant

  This trial tests whether monthly darbepoetin given to adults on the liver transplant waiting list can reduce the need for red blood cell transfusions during surgery.

  Recruiting Phase 3 Fundacion Clinic per a la Recerca Biomédica · Barcelona, Catalonia · NCT07169643

• Amniotic (placental) tissue to protect the bile-duct connection after living-donor liver transplant

  This trial will try placing a placental (amniotic) tissue graft around the bile-duct connection to see if it lowers complications in adults getting a living-donor liver transplant.

  Recruiting Phase 2 The Cleveland Clinic · Cleveland, Ohio · NCT07102550

• Cardiovascular health in children and young adults with chronic conditions

  This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.

  Recruiting Semmelweis University · Budapest and 2 other locations · NCT07086989

• Using Erector Spinae Plane Block for Pain Relief in Liver Transplant Patients

  This study is testing if a special pain relief technique called the Erector Spinae Plane block can help liver transplant patients feel less pain during and after their surgery compared to those who don’t receive it.

  Recruiting Bogomolets National Medical University · Kyiv · NCT06857331

• Collecting data on liver transplant patients and their bone health

  This study is trying to understand how liver transplants affect bone health in patients by looking at their bone mineral levels during check-ups.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06838702

• Everolimus plus epoetin alfa to try to induce tolerance after liver transplant

  This phase 1b test will switch stable adult liver transplant patients from tacrolimus to everolimus, give five doses of epoetin alfa, and then slowly withdraw everolimus to see if they can safely stop maintenance immunosuppression.

  Recruiting at 3 sites Phase 1 National Institute of Allergy and Infectious Diseases (NIAID) · San Francisco, California and 2 other locations · NCT06832189

• Identifying Prognostic Factors for Liver Disease and Transplant Needs

  This study is trying to find out which factors can help predict if people with certain liver diseases will need a transplant or develop liver cancer.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06813508

• Home-based prehabilitation program for liver transplant patients

  This study tests a home-based program that helps liver transplant patients get stronger and healthier before surgery to see if it improves their recovery and reduces complications.

  Recruiting Erasmus Medical Center · Rotterdam · NCT06808945

• Comparing two surgical techniques for bile duct connection in liver transplantation

  This study is testing two different surgical methods for connecting bile ducts during liver transplants to see which one leads to fewer complications and better recovery for patients.

  Recruiting Medical University of Warsaw · Warsaw, Masovian Voivodeship · NCT06533592

• Health Advocate program for young liver transplant recipients

  This study is testing a new program that adds a Health Advocate to help young adults who had a liver transplant manage their care and connect with resources as they transition to adult healthcare.

  Recruiting at 2 sites University of California, San Francisco · San Francisco, California and 1 other locations · NCT06386198

• Digital tool for managing liver disease in young patients

  This study is testing a new digital tool to help young people with liver disease manage their care better as they transition from pediatric to adult healthcare.

  Recruiting FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS · Bergamo, MILANO · NCT06342557

• Minimizing immunosuppression in liver transplant patients using everolimus

  This study is testing if liver transplant patients can safely lower or stop taking tacrolimus by switching to everolimus to help protect their kidney function.

  Recruiting at 10 sites Phase 2 National Institute of Allergy and Infectious Diseases (NIAID) · Phoenix, Arizona and 11 other locations · NCT06280950

• Managing bleeding during liver transplantation

  This study looks at how to better manage bleeding during liver transplants by understanding what causes it and how much blood patients might need during the surgery.

  Recruiting at 4 sites Société Française d'Anesthésie et de Réanimation · Besançon and 15 other locations · NCT06257407

• Atezolizumab plus bevacizumab for recurrent advanced hepatocellular carcinoma in liver transplant recipients

  This trial will see if the cancer drug combination atezolizumab plus bevacizumab is safe for adults whose hepatocellular carcinoma has recurred after a liver transplant.

  Recruiting at 10 sites Phase 2 Assistance Publique - Hôpitaux de Paris · Clichy and 9 other locations · NCT06254248

• Using machine perfusion to improve liver transplant outcomes for patients with liver cancer

  This study tests whether a special cooling method for liver grafts can help improve transplant success and reduce complications for patients with liver cancer.

  Recruiting Azienda Ospedaliero-Universitaria di Modena · Modena, MO · NCT06236568

• Managing fluid strategies to reduce blood loss during liver transplantation

  This study tests whether using different fluid management strategies during liver transplantation can help reduce blood loss and improve outcomes for patients.

  Recruiting National Taiwan University Hospital · Taipei · NCT06215404

• Exploring prolonged-release tacrolimus for children after liver transplant

  This study is testing if a new long-lasting version of tacrolimus can help children who have had a liver transplant avoid rejection and stay healthy by making it easier for them to take their medicine.

  Recruiting RenJi Hospital · Shanghai · NCT06183892

• Identifying risk factors for complications after liver transplantation

  This study is trying to find out what factors can lead to bleeding and clotting problems after liver transplant surgery in patients with severe liver disease to help improve their recovery.

  Recruiting Republican Specialized Scientific and Practical Medical Center of Surgery Named After V. Vakhidov · Tashkent · NCT06169592

• Using MR-proADM to predict complications after kidney and liver transplants

  This study is testing if measuring a specific protein can help doctors predict complications like delayed graft function and acute rejection in people who have received kidney or liver transplants.

  Recruiting University of Rome Tor Vergata · Rome · NCT06130046

• Using machine perfusion to improve liver transplants from steatotic donors

  This study is testing if a special machine can help make fatty livers from donors healthier for transplantation so more people can receive liver transplants.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06088758

• CMV vaccine for liver transplant candidates

  This study is testing a new vaccine for people waiting for a liver transplant to see if it can help prevent a virus called CMV and reduce the need for antiviral treatment after the transplant.

  Recruiting at 16 sites Phase 2 National Institute of Allergy and Infectious Diseases (NIAID) · Birmingham, Alabama and 17 other locations · NCT06075745

• Oral Semaglutide's Effects on Liver Fat and Body Composition in Liver Transplant Recipients with Diabetes

  This study is testing if a new diabetes medication called oral semaglutide can help liver transplant recipients reduce liver fat and improve their body composition.

  Recruiting Medanta, The Medicity, India · Gurgaon, Haryana · NCT06060392

• Placing a temporary biliary drainage stent during pediatric liver transplant to prevent bile-duct narrowing

  This study will try placing a temporary external biliary drainage stent during liver transplant in children up to 6 years old to see if it reduces bile-duct narrowing and related complications.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT06048445

• Registry for liver transplant outcomes using OCS liver perfusion

  This study is collecting information on liver transplant patients who received their organs using a special machine to see how well it works compared to other methods.

  Recruiting at 22 sites TransMedics · Birmingham, Alabama and 21 other locations · NCT05940857

• Comparing techniques for preserving liver grafts from deceased donors

  This study is testing three different ways to keep liver donations from deceased donors in good shape to see if any of them can improve their quality and help more patients receive successful transplants.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT05327478

• Using a new form of Tacrolimus after liver transplantation

  This study is testing a new version of a medication called Envarsus to see if it can help liver transplant patients avoid side effects while still keeping their immune system in check.

  Recruiting Phase 4 University of Alberta · Edmonton, Alberta · NCT05242315

• Registry for monitoring CytoSorb device use in critically ill patients

  This study is collecting information on how the CytoSorb device helps critically ill patients to improve care for conditions like septic shock and acute respiratory distress syndrome.

  Recruiting at 24 sites CytoSorbents, Inc · Klagenfurt and 27 other locations · NCT05146336

• Evaluating external biliary drainage in living donor liver transplantation

  This study is testing whether using external biliary drainage during living donor liver transplants can help reduce complications compared to the standard method.

  Recruiting Seoul National University Hospital · Seoul · NCT04622540

• Liver transplantation outcomes for patients with severe liver failure

  This study is testing how well liver transplants work for people with severe liver failure compared to those with advanced cirrhosis to see which group has better survival rates and quality of life after the transplant.

  Recruiting at 69 sites European Foundation for Study of Chronic Liver Failure · Los Angeles, California and 105 other locations · NCT04613921

• Collection of clinical specimens for pediatric liver disease research

  This study is collecting samples from children with severe liver disease who are getting liver transplants to help improve our understanding and treatment of pediatric liver conditions in the future.

  Recruiting Children's Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT04477967

• Vaccination for liver transplant candidates

  This study tests if getting vaccinated can help people waiting for a liver transplant stay healthier and avoid serious infections.

  Recruiting Hospices Civils de Lyon · Lyon · NCT04446832

• Using cabozantinib to treat liver cancer that has returned after transplant

  This study is testing if cabozantinib can help people with liver cancer that has come back after a liver transplant.

  Recruiting Phase 2 University Health Network, Toronto · Toronto, Ontario · NCT04204850

• Risk factors and outcomes of biliary complications after adult living-donor liver transplant

  This project will look at how often and why bile-duct problems happen and what the outcomes are in adults who had a living-donor liver transplant at Al-Rajhy/Assiut University.

  Recruiting Assiut University · Asyut and 1 other locations · NCT03789383

• Registry for patients needing massive blood transfusions in Australia and New Zealand

  This study is collecting information from patients in Australia and New Zealand who need large blood transfusions to help improve treatment and outcomes for future patients.

  Recruiting Monash University · Melbourne, Victoria · NCT02863250

• Monitoring liver transplant recipients for early detection of complications

  This study is testing if checking blood, urine, and tissue samples from liver transplant patients can help spot early signs of kidney problems, organ rejection, and Hepatitis C to improve their treatment and health outcomes.

  Recruiting Northwestern University · Chicago, Illinois · NCT01644903

NIH-funded research (38)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury

  A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11594128

• Biomarker-guided reduction of immunosuppression after liver transplant

  A multicenter trial tests whether using blood biomarkers to guide tapering of immunosuppression in adults with liver transplants can keep people healthy while lowering drug exposure.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11433277

• Understanding how liver disease progresses in people waiting for a liver transplant

  A study will build a knowledge base that maps how liver disease worsens over time in patients on the transplant waitlist to improve care and planning.

  NIH research University of Florida · Gainesville, United States · NIH-11428230

• Biomarkers to tailor liver transplant immunosuppression

  A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.

  NIH research Northwestern University · Chicago, United States · NIH-11412569

• Pre-Transplant Immune Health Marker Panel to Predict Liver Transplant Outcomes

  A patient-facing biomarker test used before liver transplant to help doctors estimate the risk of early death after the transplant.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11399963

• Thinking skills and self-care after a liver transplant

  This project follows people who received liver transplants to learn how changes in thinking and memory affect managing medicines, clinic visits, and overall health.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11398886

• Integrated care to improve outcomes after early liver transplant for alcohol-associated liver disease

  A multi-center study will pair liver transplant care with behavioral and biopsychosocial support to help people with alcohol-related liver disease who are considered for early transplant.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11398184

• Improving liver transplant listing with data-powered team planning

  A data-driven, team-based approach to help doctors decide which patients should be listed for a liver transplant.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11394437

• Using blood biomarkers to guide immunosuppression after liver transplant

  This project uses regular blood biomarker checks to help doctors personalize immunosuppression for people who have had a liver transplant to reduce rejection and protect the kidneys.

  NIH research Northwestern University · Chicago, United States · NIH-11392822

• Technology Aided Strategies to Help Liver Transplant Patients Stick to Their Treatment

  A new program uses technology to help people who have had a liver transplant take their medicines correctly and stay well.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11385125

• Liver transplant immune regulation to reduce injuries after surgery

  A research program at a major university is trying to improve how donated livers respond to transplantation by balancing donor and patient immune signals to lessen injury and inflammation.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11375154

• CMV Vaccine to Protect Liver Transplant Candidates

  A CMV vaccine given before liver transplant could help high-risk patients prevent CMV infection after their transplant.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11348212

• Immune signs that predict CMV after liver transplant

  Looks for patterns in antibodies and immune cells that predict who will get CMV disease after a liver transplant.

  NIH research University of Washington · Seattle, United States · NIH-11330510

• Molecular clues to liver transplant injury and recovery

  This grant studies how donor liver cells respond to injury during transplant to improve how we pick and care for livers for patients who need a transplant.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11318279

• A blood test to predict risk after a liver transplant

  This project will find out whether a short blood panel called the Liver Immune Frailty Index can identify people waiting for liver transplant who are at high risk of dying within a year after surgery.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11195036

• Improving community access to liver transplant referrals

  This project will try new ways to help people with advanced liver disease—especially Black and underinsured patients—get referred from local clinics to a liver transplant center.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11194010

• Integrated care to improve outcomes after early liver transplant for alcohol-associated liver disease

  Combining liver-transplant care with addiction and mental-health support to help people with alcohol-related liver disease who get early transplants.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11190812

• Improving Liver Transplant Outcomes by Understanding Immune Responses

  This project aims to understand how the body's immune system reacts during liver transplantation to help prevent complications and improve patient recovery.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11176154

• Improving Liver Transplants by Understanding Immune Responses

  This research aims to improve the success of liver transplants by understanding how the body's immune system reacts to the new organ, especially when the donated liver is more delicate.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11176116

• Using technology to help young transplant recipients take their medications regularly

  This study is all about helping young people who have had kidney or liver transplants remember to take their medications by using smart pillboxes that track when they take their meds, so they can get support right when they need it to stay healthy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11103311

• Improving liver transplant success by targeting immune cells in donor livers

  This study is looking at a new way to improve liver transplants by changing certain immune cells in the liver before it's transplanted, which could help prevent the body from rejecting the new liver, making it better for patients who need a transplant.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11103165

• Understanding immune responses to cytomegalovirus after liver transplants

  This study is looking at how the immune system reacts to a virus called cytomegalovirus (CMV) in people who get liver transplants from donors who have the virus, to help find ways to predict and prevent related health issues after the transplant.

  NIH research University of Washington · Seattle, United States · NIH-11098250

• Finding new ways to detect liver scarring after a transplant

  This project looks for new signs in your blood to help predict and understand liver scarring that can happen after a liver transplant for fatty liver disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11094044

• A vaccine to prevent cytomegalovirus infection in liver transplant candidates

  This study is testing a new vaccine called Triplex to help protect people waiting for a liver transplant from getting a virus called cytomegalovirus (CMV), especially those who haven't been exposed to it before and are getting organs from donors who have; the goal is to boost their immune system so they can better figh

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11092758

• Improving Donor Livers for Transplant Surgery

  This project looks at ways to make donor livers stronger and more resistant to damage, helping more people have successful liver transplants.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11086766

• Improving liver transplant outcomes for children facing social challenges

  This study looks at how tough social situations can affect kids getting liver transplants and sees if having a health advocate can help these families do better after the surgery.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11082406

• Examining how geographic differences affect liver transplant waitlist outcomes

  This study looks at how differences in liver disease scores in various areas affect who gets a liver transplant, aiming to understand why some patients have a harder time getting the help they need and to find ways to make sure everyone has a fair chance at receiving a transplant.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11063114

• Improving access to liver transplants for underserved communities

  This study is looking at how to make it easier for Black individuals and other underserved groups to get liver transplants by finding out what barriers they face and working with local doctors to improve awareness and access to this important treatment.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11057773

• Understanding barriers to liver transplant access in the Southeast

  This study looks at why some people with severe liver disease have a harder time getting liver transplants than others, especially focusing on differences related to race, income, and where they live, and it aims to find ways to make it easier for everyone to get the help they need.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11042718

• How frailty affects liver transplant outcomes in older adults with liver cancer

  This study is looking at how being frail affects recovery and health after a liver transplant in older adults with liver cancer, aiming to find better ways to care for these patients.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11010004

• Improving care for patients with alcohol-related liver disease undergoing liver transplant

  This study is looking at how better teamwork in healthcare can help people with alcohol-related liver disease who are getting a liver transplant, focusing on what helps them get referred for the transplant and how to support their recovery and sobriety afterward.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-10908450

• Investigating how relaxin receptor signaling affects liver transplant injury and inflammation resolution

  This study is looking at how a special protein called relaxin might help improve liver transplant success by reducing inflammation and damage during the surgery, and it's designed for people who are interested in better outcomes after liver transplants.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10906023

• Improving medication adherence in adolescents after liver transplant

  This study is all about helping teenagers who have had a liver transplant remember to take their important medicine to keep their new liver healthy, using friendly phone calls and video chats to support them along the way.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10891339

• Using blood biomarkers to improve liver transplant immunosuppression

  This study is looking at how certain blood tests can help doctors create personalized treatment plans for people who have received a liver transplant, making it easier to prevent rejection and protect kidney health.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10888310

• Evaluating a new biomarker panel to predict liver transplant recipient mortality

  This study is testing a new way to predict which liver transplant patients might face more risks after their surgery, so doctors can better prioritize who gets a transplant first.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-10882689

• Using miRNA profiles to improve immunosuppression management in liver transplant patients

  This study is looking at how certain tiny molecules in your blood can help doctors better manage the medications you take after a liver transplant, making sure your body doesn’t reject the new organ while reducing side effects.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10841109

• Analyzing blood samples to improve liver transplant selection for cancer patients

  This study is looking at ways to use a simple blood test to find specific cancer cells in patients with liver cancer who might need a transplant, helping doctors better understand their condition and improve their chances of a successful surgery.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-10800692

• Using AI to predict outcomes of liver transplants from deceased donors

  This study is working on a smart computer program that helps doctors look at liver tissues from donors who have passed away, making it easier to decide if the liver is good for transplant, which can lead to better outcomes and less chance of rejection.

  NIH research University of Louisville · Louisville, United States · NIH-10654166

Related topics

Quick answers

How many Liver Transplant clinical trials are recruiting right now?

41, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 32 countries. The most sites are in United States (11 trials), Italy (8 trials), France (4 trials), Netherlands (4 trials), Poland (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1: 1, Phase 3: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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