Condition

Portal Hypertension clinical trials and research

• 37Clinical trials
• 8NIH research projects
• 1New in 30 days
• 18Countries

Newest Portal Hypertension clinical trials

All recruiting trials (37)

• Endohepatology-based reclassification of treatment indication in high-risk MASLD

  This study tests whether an endohepatology assessment can change treatment decisions for adults with high-risk MASLD.

  Recruiting University Hospital Muenster · Münster · NCT07877272

• Coil-assisted small-diameter stent shunt reduction for refractory HE after TIPS

  A coil-assisted, small-diameter covered-stent technique is being tested to see if it can safely and effectively reduce shunt flow and lessen recurrent hepatic encephalopathy in people with a prior TIPS.

  Recruiting Air Force Military Medical University, China · Xi'an, Shaanxi · NCT07799948

• Austrian PBC Registry

  This registry follows adults with primary biliary cholangitis in Austrian centers to see how the disease develops over time and how biomarkers relate to complications and symptoms.

  Recruiting Medical University of Vienna · Klagenfurt, Carinthia and 10 other locations · NCT07598669

• 4D-Flow MRI to see portal hypertension and TIPS outcomes in cirrhosis

  This study tests a noninvasive 4D-Flow MRI method to see if it can safely and reliably reflect portal hypertension and predict outcomes for people with cirrhosis, including those needing a TIPS procedure.

  Recruiting at 2 sites Assistance Publique - Hôpitaux de Paris · Paris and 1 other locations · NCT07554183

• Apixaban plus carvedilol to prevent portal-hypertension complications in cirrhosis

  This will test whether adding apixaban to carvedilol can help prevent variceal bleeding, portal vein thrombosis, and other portal-hypertension complications in adults with Child-Pugh B cirrhosis.

  Recruiting Phase 4 Asian Institute Of Medical Sciences · Hyderābād, Sindh · NCT07521332

• Blood clotting and portal vein changes during TIPS placement in cirrhosis

  This project will see how blood clotting in the body and in the portal vein changes in adults with cirrhosis who are having a TIPS placed.

  Recruiting Assistance Publique - Hôpitaux de Paris · Villejuif · NCT07439939

• Comparing HVPG and endoscopic ultrasound portal pressure measurements

  This study will test whether an endoscopic ultrasound method (EUS-PPG) gives the same portal pressure readings as the standard hepatic venous pressure gradient (HVPG) in adults who need portal pressure measurement.

  Recruiting at 2 sites Military University Hospital, Prague · Prague, Bohemia and 1 other locations · NCT07424963

• Portal hypertension biobank for esophagogastric varices

  This project will try to collect clinical data, CT images, and biological samples from people with portal hypertension and esophagogastric varices to support multi-omics studies and better-tailored care.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07419724

• Portal hypertension with esophagogastric varices: endoscopic treatment vs. non-endoscopic care

  This study tests whether endoscopic treatment helps people with portal hypertension and varices compared to those who don’t get endoscopic therapy.

  Recruiting Shanghai Zhongshan Hospital · Shanghai · NCT07358663

• Comparing terlipressin and somatostatin to lower portal pressure during living-donor liver transplant

  This trial tests whether terlipressin or somatostatin better lowers portal pressure and reduces bleeding and transfusion needs in people having a right-lobe living-donor liver transplant.

  Recruiting Istanbul Medipol University Hospital · Istanbul, Bagcilar · NCT07304466

• Using TIPS to treat complicated portal hypertension in porto‑sinusoidal vascular disease

  This research tries TIPS (a shunt placed in the liver) for people with porto‑sinusoidal vascular disease who have bleeding, refractory ascites, or portal vein thrombosis from portal hypertension.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT07163689

• Handgrip strength and portal vein blood flow in people with liver cirrhosis

  This trial will test whether squeezing a handgrip changes portal vein and left gastric vein pressures and blood flow in adults with liver cirrhosis to see if muscle strength affects variceal hemodynamics.

  Recruiting at 2 sites Shanxi Provincial People's Hospital · Luoyang, Henan and 1 other locations · NCT07116096

• Removing the spleen with open debridement for necrotizing pancreatitis and left-sided portal hypertension

  This trial will test whether removing the spleen during open debridement helps adults with acute necrotizing pancreatitis and left-sided (sinistral) portal hypertension recover faster and with fewer complications than debridement alone.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT07080697

• Improving treatment strategies for bleeding from esophageal varices in portal hypertension

  This study is trying to find better ways to treat bleeding from swollen veins in the esophagus for people with portal hypertension by personalizing treatment based on their specific conditions.

  Recruiting at 10 sites Shanghai Zhongshan Hospital · Guangzhou, Guangdong and 9 other locations · NCT06970509

• EUS-guided portal pressure measurement as an alternative to hepatic venous pressure

  This trial will test whether an endoscopic ultrasound-guided portal pressure measurement (EUS-PPG) gives the same portal pressure readings as the standard HVPG in adults with portal hypertension from chronic liver disease.

  Recruiting Fundacio Privada Mon Clinic Barcelona · Barcelona · NCT06863012

• Using advanced ultrasound techniques to detect portal hypertension

  This study is testing a new ultrasound method to see if it can safely and accurately find portal hypertension in patients without needing invasive procedures.

  Recruiting at 3 sites Mayo Clinic · Scottsdale, Arizona and 2 other locations · NCT06797193

• Early TIPS for patients with liver cirrhosis and ascites

  This study is testing if a procedure called TIPS can help people with liver cirrhosis and fluid buildup in their abdomen feel better compared to standard treatments like medications and draining the fluid.

  Recruiting University Hospital Freiburg · Freiburg im Breisgau · NCT06576934

• Stopping non-selective beta-blockers in people with cirrhosis whose main cause is controlled

  This study will try stopping non-selective beta-blockers in adults with cirrhosis who have their primary liver disease controlled, low liver stiffness, and no varices to see if varices come back within one year.

  Recruiting Chinese University of Hong Kong · Sydney and 7 other locations · NCT06549673

• Using carvedilol to prevent liver complications in patients with advanced chronic liver disease

  This study is testing if the medication carvedilol can help prevent serious liver problems in people with advanced chronic liver disease and high blood pressure in the liver.

  Recruiting Phase 4 Chinese University of Hong Kong · Hong Kong · NCT06449339

• Gathering data on hepatomiR for liver disease outcomes

  This study is trying to see how a new test for liver disease can help doctors understand and predict serious problems in patients with chronic liver issues.

  Recruiting Karl Landsteiner University of Health Sciences · Sankt Pölten, Lower Austria · NCT06432582

• Noninvasive Prediction of Portal Hypertension in Cirrhosis Using STVi

  This study tests whether the liver STVi ultrasound measurement can noninvasively predict clinically significant portal hypertension in adults with cirrhosis.

  Recruiting First Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT06316869

• Measuring portal pressure in patients with advanced liver disease using endoscopic ultrasound

  This study is testing if a new way of measuring pressure in the liver using endoscopic ultrasound is better than the traditional method for people with advanced liver disease and high blood pressure in the portal vein.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT06266260

• Using Ga-PSMA PET/MRI to assess liver cirrhosis

  This study is testing a new imaging method to see if it can help doctors better understand liver function and damage in people with liver cirrhosis.

  Recruiting Massachusetts General Hospital · Charlestown, Massachusetts · NCT06265272

• Non-invasive method to estimate portal and hepatic vein pressure

  This study is testing a new, non-invasive MRI method to see if it can accurately measure blood pressure in the liver for people with serious liver disease.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06210178

• Using spleen stiffness measurement to predict outcomes in liver disease patients with acute liver injury

  This study is testing if measuring spleen stiffness can help predict how patients with chronic liver disease and acute liver injury will do in the short term.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT06173947

• Follow-up on the Lifetech Cera Vascular Plug System

  This study is looking to see how well the Lifetech Cera Vascular Plug System works and if it’s safe for people who need treatment for blood vessel issues.

  Recruiting at 9 sites Lifetech Scientific (Shenzhen) Co., Ltd. · Bad Hersfeld and 8 other locations · NCT06099015

• Registry for patients undergoing TIPS implantation for portal hypertension

  This study is collecting information from patients with serious portal hypertension who are getting a TIPS procedure to see how well it works and what complications might happen afterward.

  Recruiting University Hospital Freiburg · Freiburg im Breisgau · NCT05782556

• Assessing muscle loss and liver health in patients with advanced liver disease

  This study is testing how muscle loss affects liver health in people with advanced liver disease by looking at their body composition and overall well-being over two years.

  Recruiting at 3 sites Linkoeping University · Eksjö and 2 other locations · NCT05502198

• Using 3D-MRE to assess liver disease and portal hypertension

  This study is testing if a new type of imaging called 3D-MRE can help doctors better understand and manage portal hypertension in patients with cirrhosis and advanced liver disease.

  Recruiting Shengjing Hospital · Shenyang, Liaoning · NCT05475015

• Noninvasive method to estimate portal hypertension using ultrasound

  This study is testing a new ultrasound method to see if it can accurately measure pressure in the liver for people with liver diseases and portal hypertension.

  Recruiting at 3 sites Phase 3 Thomas Jefferson University · Philadelphia, Pennsylvania and 2 other locations · NCT05470205

• Surgery to improve liver function in cirrhosis patients

  This study tests whether a specific surgery can help improve liver function in patients with cirrhosis who have an enlarged spleen.

  Recruiting Northern Jiangsu People's Hospital · Yangzhou, Jiangsu · NCT05325437

• EUS-guided measurement of portal pressure gradient

  This study will test an endoscopic ultrasound (EUS) technique to directly measure portal pressure in people with cirrhosis to see if it can safely and accurately indicate portal hypertension.

  Recruiting Phase 1/2 Chinese University of Hong Kong · Hong Kong, Hong Kong · NCT04633356

• Predicting liver failure after surgery in patients with chronic liver disease

  This study is trying to find out what causes liver failure after surgery in people with chronic liver disease to help doctors better predict risks for their patients.

  Recruiting University Hospital, Bonn · Bonn · NCT04578301

• Non-invasive evaluation for patients with portal hypertension receiving TIPS

  This study is testing new ways to monitor patients with portal hypertension who are getting a TIPS procedure to see how well they do afterward.

  Recruiting University Hospital, Bonn · Bonn · NCT04393519

• Preventing liver complications after TIPS placement with rifaximin and lactulose

  This study is testing if taking rifaximin and lactulose can help prevent brain problems in adults with liver cirrhosis after they have a procedure called TIPS.

  Recruiting at 6 sites Phase 4 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Leuven and 5 other locations · NCT04073290

• Registry for patients with portal hypertension undergoing TIPS

  This study is looking at patients with serious liver disease who have had a specific procedure called TIPS to see how they do afterwards and if certain markers can help predict any problems.

  Recruiting Medical University of Vienna · Vienna, State of Vienna · NCT03409263

• Observational study on advanced chronic liver diseases in Vienna

  This study looks at patients with advanced chronic liver diseases in Vienna to see how their condition affects blood pressure in the liver and to collect samples for future research.

  Recruiting Medical University of Vienna · Vienna · NCT03267615

NIH-funded research (8)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Noninvasive portal pressure estimation using ultrasound-based subharmonic signals

  A noninvasive ultrasound method to estimate portal vein pressure in adults with cirrhosis to help manage varices and ascites.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11625565

• Noninvasive MRI test to measure liver and portal blood pressure

  An advanced MRI technique to measure pressure in the liver and portal circulation for people with chronic liver disease or cirrhosis.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11292865

• How molecular changes in the liver cause portal hypertension

  This project looks at how changes in proteins that control nitric oxide in liver blood vessel cells lead to portal hypertension in people with liver injury.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11290437

• Under-the-skin medicine for fluid buildup (ascites) from portal hypertension

  A new injectable medicine given under the skin to help people with cirrhosis who have hard-to-treat fluid buildup in the belly.

  NIH research Pharmain Corporation · Bothell, United States · NIH-11193954

• Noninvasive method to measure portal vein pressure in cirrhosis

  A noninvasive ultrasound technique called SHAPE could measure portal vein pressure in people with cirrhosis to help manage complications like variceal bleeding and ascites.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11121019

• Noninvasive evaluation of liver pressure and health using advanced imaging techniques

  This study is testing a new, painless way to check liver health and pressure using advanced imaging technology, which could help people with chronic liver disease get better and safer care without needing invasive procedures.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11059159

• Understanding how liver injury affects blood flow in portal hypertension

  This study is looking into how liver damage affects blood flow in people with portal hypertension, focusing on certain proteins that help control blood flow, so we can better understand the condition and find new ways to treat it.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11031981

• Understanding how immune cells affect high blood pressure in the liver

  This study is looking at how certain immune cells in the liver might be causing high blood pressure in the portal vein, which can happen in people with chronic liver disease, and it hopes to find new ways to help lower that pressure and improve treatment options for patients.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-10814212

Related topics

Quick answers

How many Portal Hypertension clinical trials are recruiting right now?

37, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in China (12 trials), Germany (6 trials), Austria (4 trials), United States (3 trials), France (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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