Hepatology home hospital program for people with advanced liver disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot interventional program offers inpatient-level hepatology care delivered at home by the Massachusetts General Hospital Home Hospital team. Eligible adults with cirrhosis presenting to the emergency department or general medicine service who have ascites, hepatic hydrothorax, or hepatic encephalopathy may be enrolled. Patients with prior solid-organ transplant, on hemodialysis, MELD >20, low cognitive screening (S-ANT1 <10), active hemodynamically significant GI bleed or alcohol withdrawal, or needing routine controlled substances are excluded. The program aims to replace or shorten hospital stays by providing monitoring, treatments, and procedures in the home setting under hospital oversight.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult patients ≥ 18 years old with diagnosis of cirrhosis based on histology, radiology, and/or elastography presenting to the emergency department or inpatient general medicine service
2. Patients must have one of the following:

   1. Ascites (requiring diuretics or serial large volume paracenteses)
   2. Hepatic hydrothorax (requiring diuretics)
   3. Hepatic encephalopathy (requiring medications)

Exclusion Criteria: All existing MGB home hospital criteria apply, with the following taking precedent for this specific condition

1. History of solid organ transplantation
2. On hemodialysis
3. MELD score \> 20
4. Score \<10 on Simplified Animal Naming Test (S-ANT1)
5. Current admission for hemodynamically significant GI bleeding or alcohol withdrawal
6. Require routine administration of controlled substances
7. Those deemed ineligible based on the MGH Home Hospital, inpatient medicine or hepatology clinician evaluation

Where it's running

• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting
• Massachusetts General Hospital
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Nneka Ufere, MD, MSCE
• Email: nufere@partners.org
• Phone: 617-643-3408

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.