Investigating treatments for liver cirrhosis complications
Official title: Liver Cirrhosis Network: Clinical Research Center - Mayo Clinic
Funded at Mayo Clinic Rochester · NIH-10909036 · Data updated 2026-11-12
This study is looking to help people with compensated liver cirrhosis by tracking their health over time and testing if a medication called simvastatin can improve their condition, while also using advanced technology to predict potential complications.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 13, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $239,180 |
| NIH project number | 5U01DK130181-04 |
| Project ID | NIH-10909036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with compensated liver cirrhosis who are seeking new treatment options.
✕Less likely to help
Patients with decompensated liver cirrhosis or those not eligible for statin therapy may not benefit from this research.
What this research studies
This research focuses on understanding and improving outcomes for patients with compensated liver cirrhosis. It involves a multicenter observational study to gather extensive data on the natural history of cirrhosis and a clinical trial testing the effectiveness of simvastatin compared to a placebo. The study aims to develop an artificial intelligence algorithm to predict complications related to cirrhosis by analyzing clinical, laboratory, and imaging data. Patients will be monitored over time to assess the impact of the treatment on their liver function and overall health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management of liver cirrhosis complications.
How similar studies have gone: Previous research has shown promise in using statins for liver function improvement, but this specific approach is novel and aims to provide definitive evidence.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Shah, Vijay H. — Mayo Clinic Rochester
- Study coordinator: Shah, Vijay H.
Related research
Other NIH-funded projects on the same topics.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial
This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.
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First-in-class treatment for liver cirrhosis with portal hypertension
A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.