Investigating treatments for liver cirrhosis complications
Liver Cirrhosis Network: Clinical Research Center - Mayo Clinic
This study is looking to help people with compensated liver cirrhosis by tracking their health over time and testing if a medication called simvastatin can improve their condition, while also using advanced technology to predict potential complications.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10909036 on NIH RePORTER |
What this research studies
This research focuses on understanding and improving outcomes for patients with compensated liver cirrhosis. It involves a multicenter observational study to gather extensive data on the natural history of cirrhosis and a clinical trial testing the effectiveness of simvastatin compared to a placebo. The study aims to develop an artificial intelligence algorithm to predict complications related to cirrhosis by analyzing clinical, laboratory, and imaging data. Patients will be monitored over time to assess the impact of the treatment on their liver function and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with compensated liver cirrhosis who are seeking new treatment options.
Not a fit: Patients with decompensated liver cirrhosis or those not eligible for statin therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management of liver cirrhosis complications.
How similar studies have performed: Previous research has shown promise in using statins for liver function improvement, but this specific approach is novel and aims to provide definitive evidence.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Shah, Vijay H. — Mayo Clinic Rochester
- Study coordinator: Shah, Vijay H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.