Using subharmonic imaging with liver stiffness and platelet count to find high-risk esophageal and gastric varices in people with cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with clinically diagnosed liver cirrhosis who have undergone gastroscopy will receive subharmonic-assisted pressure estimation (SHAPE), a liver stiffness measurement (LSM), and a platelet count (PLT). The results will be combined into a diagnostic model and compared against gastroscopy findings for high-risk varices. Patients with prior variceal bleeding, TIPS, endoscopic variceal therapy, liver cancer, portal vein thrombosis, splenectomy, recent blood product transfusion, or recent drugs affecting platelets are excluded. This is a single-center interventional protocol conducted at The First Hospital of Jilin University in Changchun, China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ① Be at least 18 years old② Clinically diagnosed as liver cirrhosis (based on medical history, physical signs, laboratory tests, imaging or liver biopsy)③ Underwent a gastroscopy④ The informed consent form has been signed

Exclusion Criteria:

* ① Previous EV bleeding or having received TIPS/ endoscopic treatment.② History of concurrent liver cancer, portal vein thrombosis, and splenectomy.③ Having used drugs that affect platelet count, liver function or coagulation function in the body within one week, and having a recent history of blood product infusion.

Where it's running

• The First Hospital of Jilin University
  Changchun, Jilin, China Recruiting

Study contacts

• Study coordinator: Dezhi Zhang, doctorate
• Email: dezhi@jlu.edu.cn
• Phone: 0431-88782190

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.