Predicting health outcomes for people with liver cirrhosis
LIVOPT -- LIVer cirrhosis - Optimizing Prediction of Patient OuTcomes
This project will create better ways to predict which people with liver cirrhosis — especially older adults — are most likely to have hospital stays, serious complications, or die.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11137839 on NIH RePORTER |
What this research studies
If you have liver cirrhosis, this project uses medical records from nine Chicago-area health systems to learn how the disease progresses and who ends up hospitalized or dying. The team will analyze lab results, diagnoses, hospital visits, and other electronic health record information from about 160,000 patients captured in the CAPriCORN network. They will build and test prediction models and compare risk patterns in older versus younger adults. Results will aim to point out which patients may need closer monitoring or earlier interventions.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed with liver cirrhosis who receive care within the participating Chicago-area health systems and whose electronic health records are included in CAPriCORN.
Not a fit: People without cirrhosis, those treated outside the participating health systems, or whose records are not captured in the CAPriCORN network are unlikely to be included or directly benefit from this project.
Why it matters
Potential benefit: If successful, the work could help clinicians spot high-risk patients earlier so they can offer closer follow-up, preventive care, or timely treatment to reduce hospital stays and deaths.
How similar studies have performed: Some prior prediction models for cirrhosis exist but were limited by narrow or single-system data, and using a large, diverse multi-system EHR network is a broader and relatively novel approach.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Ladner, Daniela P — Northwestern University
- Study coordinator: Ladner, Daniela P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.