Investigating the link between gut bacteria and liver cancer risk in people with cirrhosis.
Epidemiology of the gut-liver axis and hepatocellular carcinoma risk in a multiethnic liver cirrhosis cohort: defining the role of bacteria, metabolites, and glycoproteins
This study is looking at how the bacteria in your gut might affect the risk of liver cancer in people with liver cirrhosis, especially in the Latinx community, and it hopes to find helpful markers that could lead to better ways to screen and prevent cancer for those at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11172694 on NIH RePORTER |
What this research studies
This research focuses on understanding how the gut-liver axis influences the risk of developing hepatocellular carcinoma (HCC) in patients with liver cirrhosis, particularly among the Latinx population. By analyzing gut bacteria, metabolites, and glycoproteins, the study aims to identify specific biological markers that could indicate a higher risk of HCC. Participants will be part of a multicenter cohort study, contributing samples and data that will help uncover the relationship between diet, microbiome composition, and liver cancer risk. The findings could lead to improved screening and prevention strategies for at-risk individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with liver cirrhosis, particularly those from the Latinx community.
Not a fit: Patients without liver cirrhosis or those who do not belong to the targeted demographic may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and prevention strategies for liver cancer in patients with cirrhosis.
How similar studies have performed: Previous research has shown promising results in understanding the gut-liver axis and its implications for liver disease, indicating that this approach has potential for success.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Hussain, Shehnaz Khursheed — University of California at Davis
- Study coordinator: Hussain, Shehnaz Khursheed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.