Condition

Liver Diseases clinical trials and research

• 33Clinical trials
• 32NIH research projects
• 29Countries

Newest Liver Diseases clinical trials

All recruiting trials (33)

• Everolimus-based calcineurin-free immunosuppression one year after liver transplant

  This trial tests whether switching to or using everolimus with reduced calcineurin inhibitors after year one post-liver transplant can protect kidney function while maintaining graft health in adults at low rejection risk.

  Recruiting Phase 3 Hannover Medical School · Heidelberg, Baden-Wurttemberg and 15 other locations · NCT07739914

• Metastatic liver cancer patient registry from multiple Chinese centers

  This is a registry that collects real-world data on adults with liver metastases to understand patterns and prognosis and to support future research.

  Recruiting at 2 sites Anhui Provincial Hospital · Bengbu, Anhui and 2 other locations · NCT07602504

• Safety and how the drug behaves in adults with moderate to severe liver impairment

  This study tests the safety and how INCB123667 moves through the body when taken by adults with moderate to severe liver impairment.

  Recruiting at 4 sites Phase 1 Incyte Corporation · Chandler, Arizona and 3 other locations · NCT07559474

• Single-probe FibroScan for measuring liver stiffness

  This project will try a single-probe FibroScan to measure liver stiffness in adults with chronic liver disease and compare its results to the standard M and XL probes.

  Recruiting Echosens · Besançon and 3 other locations · NCT07400289

• Using polyene phosphatidylcholine to protect the liver after hepatectomy

  This test checks whether giving polyene phosphatidylcholine before surgery plus magnesium isoglycyrrhizinate after surgery better prevents liver injury in people having laparoscopic liver resection for hepatocellular carcinoma.

  Recruiting Phase 4 Anhui Provincial Hospital · Hefei, Anhui · NCT07150624

• CRISPR-edited donor liver transplant to reduce rejection

  This trial will try transplanting deceased-donor livers that have had key HLA genes removed with CRISPR to see if they cause less rejection in adults needing a liver transplant.

  Recruiting Phase 1/2 American Organ Transplant and Cancer Research Institute LLC · Beijing, Changping · NCT07053488

• High-protein, plant-dominant diet for people with liver cirrhosis

  This 6-month test compares a high-protein, mostly plant-based diet to a usual low-fat animal-protein diet in adults with decompensated cirrhosis who are awaiting kidney transplant to see which better preserves nutrition and muscle.

  Recruiting at 2 sites Agricultural University of Athens · Athens, Attica and 1 other locations · NCT07028580

• Iron buildup and liver problems in adults more than 10 years after an allogeneic stem cell transplant

  This project will see if long-term iron buildup raises the risk of liver complications in adults who had an allogeneic stem-cell transplant at least 10 years ago.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07028112

• Normothermic machine perfusion to re-evaluate declined donor livers and shorten transplant waiting time

  This trial tests whether keeping declined donor livers functioning on a normothermic perfusion machine can make more livers usable and help adults on the transplant waiting list (ReMELD‑Na ≤21) get transplanted sooner.

  Recruiting at 10 sites Charite University, Berlin, Germany · Hamburg, Free and Hanseatic City of Hamburg and 9 other locations · NCT06874296

• Microbiota augmentation to restore healthy gut bacteria in hospitalized liver patients

  This trial will test whether giving defined groups of healthy gut bacteria is safe and can restore key gut metabolites in hospitalized adults with liver disease who have low fecal butyrate and deoxycholic acid.

  Recruiting Phase 1 University of Chicago · Chicago, Illinois · NCT06871111

• Predicting liver disease complications and cancer development in patients

  This study is testing if a new way of monitoring patients with advanced liver disease can help predict serious health issues and cancer better than standard care.

  Recruiting University Hospital Muenster · Münster, North Rhine-Westphalia · NCT06523608

• New method to measure liver stiffness with FibroScan

  This project will test a new way to measure liver stiffness with a FibroScan device in adults being treated for or suspected of having liver disease at two French hospitals.

  Recruiting at 2 sites Echosens · Orsay and 1 other locations · NCT06519331

• Evaluating robotic surgery for liver tumor removal

  This study is testing if using robotic surgery to remove liver tumors is safer and more effective than traditional surgery methods for patients with liver tumors.

  Recruiting Zhejiang University · Hangzhou, Zhejiang · NCT06353672

• Using deep learning to assess liver diseases with ultrasound data

  This study is testing if a new deep learning method using ultrasound data can better identify liver diseases in patients compared to traditional methods.

  Recruiting at 4 sites Technische Universität Dresden · Dresden and 3 other locations · NCT06317181

• Helping people with alcohol-related liver disease find and start alcohol treatment

  This trial tests whether a tailored web app plus a follow-up coaching bundle can help people with alcohol-related liver disease start and stay in alcohol-use treatment.

  Recruiting Henry Ford Health System · Detroit, Michigan · NCT06269510

• Examining liver inflammation in patients with non-alcoholic steatohepatitis

  This study is trying to see if examining liver inflammation in people with non-alcoholic steatohepatitis can help identify those at risk for serious liver problems.

  Recruiting Hospices Civils de Lyon · Lyon, Auvergne-Rhône-Alpes · NCT06152250

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Veteran-Centered Care for Advanced Liver Disease

  This study is testing a new way to care for Veterans with advanced liver disease by using telemedicine to help them talk about their health and treatment options to see if it leads to more discussions about liver transplants.

  Recruiting at 4 sites VA Office of Research and Development · Little Rock, Arkansas and 7 other locations · NCT06068491

• Transitional care for patients with chronic liver disease after hospital discharge

  This study tests a new follow-up care program for people with advanced liver disease after they leave the hospital to see if it helps them stay healthier and reduces the need for readmissions.

  Recruiting at 4 sites Indiana University · Chicago, Illinois and 3 other locations · NCT05733832

• Noninvasive method to estimate portal hypertension using ultrasound

  This study is testing a new ultrasound method to see if it can accurately measure pressure in the liver for people with liver diseases and portal hypertension.

  Recruiting at 3 sites Phase 3 Thomas Jefferson University · Philadelphia, Pennsylvania and 2 other locations · NCT05470205

• Using 4D-MRI to identify liver fibrosis

  This study is testing a new way to use 4D-MRI to help doctors see how stiff the liver is, which could improve the diagnosis of liver fibrosis in people with chronic liver diseases.

  Recruiting at 2 sites University Hospital, Basel, Switzerland · Liestal, Basel-Landschaft and 1 other locations · NCT05385237

• Modeling liver blood flow during surgery

  This study is testing a new way to predict blood flow changes during liver surgeries to help doctors choose the right patients and reduce the risk of liver failure after surgery.

  Recruiting Assistance Publique - Hôpitaux de Paris · Villejuif, Val de Marne · NCT05339984

• Using muscle assessment to predict health outcomes in liver disease patients

  This study is testing if a quick muscle check during an MRI can help predict health outcomes for patients with liver disease.

  Recruiting University of Chicago · Chicago, Illinois · NCT05264051

• Liver transplantation outcomes for patients with severe liver failure

  This study is testing how well liver transplants work for people with severe liver failure compared to those with advanced cirrhosis to see which group has better survival rates and quality of life after the transplant.

  Recruiting at 69 sites European Foundation for Study of Chronic Liver Failure · Los Angeles, California and 105 other locations · NCT04613921

• Evaluating outcomes of hepatobiliopancreatic surgery

  This study looks at the health outcomes and survival rates of patients who have had surgery for liver, bile duct, or pancreas issues to see how well they do after the operation.

  Recruiting Fundacion Miguel Servet · Pamplona, Navarre · NCT04556019

• How chronic liver diseases connect with other long-term illnesses

  We will look back at hospital records to see if chronic liver diseases are linked with other systemic illnesses in adults who visited Tzu Chi gastroenterology clinics.

  Recruiting Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation · New Taipei City · NCT04525833

• Collection of clinical specimens for pediatric liver disease research

  This study is collecting samples from children with severe liver disease who are getting liver transplants to help improve our understanding and treatment of pediatric liver conditions in the future.

  Recruiting Children's Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT04477967

• Understanding Primary Sclerosing Cholangitis in Children

  This study is trying to learn more about how primary sclerosing cholangitis affects children by collecting health information and samples to understand the disease better and its connection to other conditions.

  Recruiting at 9 sites Arbor Research Collaborative for Health · Los Angeles, California and 11 other locations · NCT04181138

• Preventing liver complications after TIPS placement with rifaximin and lactulose

  This study is testing if taking rifaximin and lactulose can help prevent brain problems in adults with liver cirrhosis after they have a procedure called TIPS.

  Recruiting at 6 sites Phase 4 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Leuven and 5 other locations · NCT04073290

• Observational research on chronic diseases and healthcare analytics

  This study looks at health records to see how well different treatments work for chronic diseases like HIV and hepatitis, aiming to improve patient care and support.

  Recruiting Epividian · Durham, North Carolina · NCT03813862

• Effects of Panax Ginseng on Liver Function in Adults

  This study is testing if taking Panax Ginseng can help improve liver health in adults with mild liver function issues.

  Recruiting Pusan National University Yangsan Hospital · Yangsan · NCT03775837

• Comparing inflammatory profiles in alcoholic liver disease

  This study is trying to see how inflammation works in people with different stages of alcoholic liver disease compared to healthy individuals to better understand the condition.

  Recruiting University Hospital, Lille · Lille · NCT03773887

• Observational study on liver injuries from drugs and alternative medicines

  This study is trying to find out how certain prescription drugs and alternative medicines can cause liver injuries in people, while also looking for risk factors and ways to improve diagnosis.

  Recruiting at 6 sites Duke University · Los Angeles, California and 5 other locations · NCT00345930

NIH-funded research (32)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Multimodal Tools to Diagnose and Predict Risk in Alcohol- and Metabolic-Related Liver Diseases

  A Mayo Clinic-led study will use advanced computer analysis of multi-omics data and tissue images to improve diagnosis and prognosis for ALD, MASLD, and MetALD.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11415005

• Mass spectrometry tools to find liver disease biomarkers in people with fatty liver disease

  A Mayo Clinic team is testing a new, sensitive blood test method to spot biomarkers from liver disease (NAFLD/NASH) using extracellular vesicles, with the goal of better diagnosing and tracking progression.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11411089

• Circular RNAs in Cholestatic Liver Diseases

  This project looks at circular RNAs and other noncoding RNAs to understand their role in a liver disease called primary sclerosing cholangitis and how they may influence inflammation and scarring of bile ducts.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11377361

• Molecular tricks of T cells in kids with chronic liver disease

  A training program to understand why T cells don’t work well in children with chronic liver disease and how bile acids might be causing the problem.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11371829

• Harnessing liver cell flexibility to treat cholestatic liver diseases

  Aims to turn liver cells into the right type to help people with cholestatic liver diseases, including Alagille syndrome.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11342554

• Understanding Rare Pediatric Liver Diseases inChiLDReN network

  A national network study aims to grow knowledge about rare childhood liver diseases by sharing data and samples to improve care.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11337617

• Making guide RNAs to support in-body gene editing treatments for metabolic liver diseases

  This project is developing ways to produce the RNA guides needed for in-body gene-editing treatments aimed at people with inherited metabolic liver conditions.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11337355

• Understanding and guiding liver cell competition to repair damaged livers

  Researchers are studying how healthy and mutant liver cells compete with each other to repair damaged livers, aiming to develop ways to help the liver heal itself in people with alcoholic liver disease.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11334333

• Gut health and PTSD in veterans with inflammatory bowel disease

  A study explores how the gut microbiome and chronic stress from military experiences may influence inflammatory bowel disease in veterans.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11333100

• Acute and chronic limits of RNA interference therapies for liver diseases

  This grant explores why certain RNA-based therapies delivered by a virus can cause liver toxicity, with the goal of making safer, one-time liver treatments possible.

  NIH research Stanford University · Stanford, United States · NIH-11326864

• Liver problems during pregnancy and how they affect moms and babies

  Looking at whether high bile acid levels in pregnant people with liver disease lead to higher risks of preterm birth and stillbirth.

  NIH research University of Rhode Island · Kingston, United States · NIH-11290318

• Gut microbes and diarrhea risk in Gulf War veterans

  This project looks at whether changes in gut microbes explain why Gulf War and other deployed veterans get frequent diarrhea and related gut problems.

  NIH research Jesse Brown VA Medical Center · Chicago, United States · NIH-11213927

• Improving Gene Therapy for Liver Conditions

  This research aims to make gene therapies safer and more effective for people with liver conditions by understanding how they sometimes cause liver problems.

  NIH research Stanford University · Stanford, United States · NIH-11137041

• Gut microbiome, fiber, and short-chain fatty acids in Veterans with Gulf War Illness

  This project tests whether Veterans with Gulf War Illness who have gut problems have lower levels of helpful gut bacteria and short-chain fatty acids, and whether eating more fiber relates to fewer digestive symptoms.

  NIH research Wm S. Middleton Memorial Veterans Hosp · Madison, United States · NIH-11132615

• Understanding Gut Health in Veterans with Deployment-Related GI and Liver Conditions

  This project explores how the gut microbiome and PTSD might be connected to inflammatory bowel disease and other digestive issues in Veterans.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11132581

• Understanding how liver cells compete to improve treatment for liver diseases

  This study is looking at how healthy liver cells can help get rid of damaged ones, and it aims to find new ways to help the liver heal better, which could lead to better treatments for people with chronic liver diseases.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11131169

• Understanding Rare Liver Conditions in Children

  This effort brings together experts to learn more about rare liver conditions affecting children, aiming to find better ways to care for them.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11124874

• Circular RNAs and Liver Diseases

  This work explores how tiny genetic molecules called circular RNAs might contribute to serious liver conditions like primary sclerosing cholangitis.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11061406

• Understanding how liver cells respond to bile acid injury in children with cholestatic liver diseases

  This study is looking at how children's livers react to certain injuries caused by bile acids, especially in kids with cholestatic liver diseases like biliary atresia, to find out why they often have more serious liver problems than adults, with the hope of discovering new treatments that could help reduce the need for

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11056716

• Investigating liver diseases and their impact on pregnancy complications

  This study is looking at how certain liver conditions during pregnancy, like intrahepatic cholestasis and non-alcoholic fatty liver disease, can impact the health of both moms and babies, and it hopes to find ways to help improve outcomes for pregnant women facing these issues.

  NIH research University of Rhode Island · Kingston, United States · NIH-11043433

• Correcting hereditary tyrosinemia type 1 and other liver diseases using gene therapy.

  This study is testing a new way to treat hereditary tyrosinemia type 1 (HT1) by using a special gene therapy that delivers healthy genes directly to the liver, which could help patients avoid liver transplants and long-term medications.

  NIH research Hydrogene Therapeutics INC · Houston, United States · NIH-11005449

• Investigating the gut microbiome's role in liver disease and PTSD among US Veterans

  This study is looking at how PTSD might impact the health of veterans' livers and gut bacteria, hoping to find new ways to help improve their overall health by understanding the connections between these areas.

  NIH research VA Veterans Administration Hospital · Richmond, United States · NIH-10975928

• Understanding how gut bacteria affect gastrointestinal diseases in veterans.

  This study is looking at how the bacteria in the gut might affect stomach and liver problems in veterans, especially those with Gulf War Illness, to find new ways to help improve their health and ease symptoms like diarrhea and inflammatory bowel diseases.

  NIH research Jesse Brown VA Medical Center · Chicago, United States · NIH-10950290

• A mentoring program to support underrepresented researchers in digestive and liver diseases

  This program is designed to help underrepresented individuals in medicine, including those with disabilities, by connecting them with mentors and training in digestive and liver diseases, so they can become successful researchers and improve healthcare for everyone.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-10915608

• Investigating the role of a specific RNA in liver diseases related to bile flow issues

  This study is looking at how a specific type of RNA might play a role in liver damage for people with primary sclerosing cholangitis (PSC), with the hope that understanding this could help find new ways to treat the condition.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10909545

• Blocking liver cell aging to treat chronic liver diseases

  This study is looking at how stopping liver cells from aging might help people with chronic liver diseases, and they're testing this idea in animals to find new treatments that could make a difference for patients like you.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10901943

• Investigating circular RNAs in liver diseases

  This study is looking at how certain tiny molecules in your body, called circular RNAs, might be linked to primary sclerosing cholangitis (PSC), a liver disease, to help find new ways to understand and treat the condition.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10898186

• Investigating the gut microbiome's role in gastrointestinal issues among Gulf War veterans

  This study is looking at how the bacteria in your gut might influence stomach and liver problems in veterans with Gulf War Illness, and it hopes to find ways to improve your gut health and reduce symptoms by examining your diet and gut bacteria.

  NIH research Wm S. Middleton Memorial Veterans Hosp · Madison, United States · NIH-10844378

• Investigating the gut microbiome's role in gastrointestinal and liver diseases in veterans with PTSD.

  This study is looking at how the bacteria in your gut might affect stomach and liver problems in veterans, especially those with PTSD, and it invites you to share your gut health samples to help us understand these connections better.

  NIH research Veterans Health Administration · Nashville, United States · NIH-10830928

• A new method for screening liver diseases using multiple miRNA markers

  This study is working on a new, affordable way to quickly check for several tiny molecules in your body that can help spot liver diseases linked to alcohol use and diabetes, making it easier for doctors to catch these issues early and keep track of your health.

  NIH research Kasa Bio, L.l.c. · Peachtree Corners, UNITED STATES · NIH-10821132

• Investigating a new treatment for liver diseases using specific kinase inhibitors

  This study is testing a new treatment called ABI-171 for people with nonalcoholic fatty liver disease (NAFLD) and its more serious form, NASH, to see if it can help improve liver health by reducing inflammation and scarring.

  NIH research Avanti Biosciences, INC. · East Setauket, United States · NIH-10696380

• Investigating how neutrophil elastase affects fatty liver diseases related to obesity

  This study is looking at how a specific enzyme called neutrophil elastase affects liver problems related to obesity, especially those caused by a high-fat and sugary diet, and it hopes to find ways to reduce inflammation and improve liver health.

  NIH research Boston University Medical Campus · Boston, United States · NIH-10477430

Related topics

Quick answers

How many Liver Diseases clinical trials are recruiting right now?

33, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 29 countries. The most sites are in United States (12 trials), France (7 trials), Germany (5 trials), China (5 trials), Switzerland (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 1: 2, Phase 4: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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