Using fecal microbiota transplantation to treat liver cirrhosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of fecal microbiota transplantation (FMT) on patients with liver cirrhosis, particularly focusing on complications, disease progression, and mortality. The study will randomly assign 220 patients experiencing acute decompensation of liver cirrhosis into two groups: one receiving FMT and the other receiving a placebo. Researchers will monitor the patients for one year to assess changes in gut microbiota, gut barrier function, systemic inflammation, and immune response, aiming to understand the mechanistic effects of FMT on liver disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-75 years
* Liver cirrhosis with Child-Pugh ≤ 12
* Acute decompensation requiring intervention (ascites, gastrointestinal bleeding, infections leading to progressive liver failure, overthepatic encephalopathy, alcoholic hepatitis)

Exclusion Criteria:

* More than one organ failure defined by CLIF-SOFA score
* Untreated malignancy apart from non-melanoma skin cancer
* Untreated viral hepatitis
* HIV
* Inflammatory bowel disease
* Celiac disease
* Clostridioides Difficile infection
* Pregnancy
* Unable to participate based on medical judgement

Where it's running

• Department of Hepatology and Gastroenterology, Aarhus University Hospital
  Aarhus, Denmark Recruiting

Study contacts

• Study coordinator: Karen Louise Thomsen, PhD
• Email: karethom@rm.dk
• Phone: +4526949260

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.