Predicting liver failure after surgery in patients with chronic liver disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify the precipitants and predictors of Acute-on-Chronic Liver Failure (ACLF) following surgical interventions in patients with chronic liver disease. By investigating clinical markers and molecular mechanisms associated with ACLF, the study seeks to develop a risk stratification tool for elective surgeries in cirrhotic patients. The research will involve prospective data collection from patients undergoing surgery, with a focus on understanding the underlying causes of ACLF and its relationship with surgical procedures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female adult (≥18 years) patient
* With or without liver cirrhosis (diagnosed either histologically or by a combination of clinical, laboratory and radiological signs)
* Or Non-cirrhotic portal hypertension
* Non-pregnant, non-lactating females
* Ability to understand the patient information and to personally sign and date the informed consent to participate in the study
* The patient is co-operative and available for the entire study
* Provided written informed consent
* Indication for surgical intervention

Exclusion Criteria:

* Pregnant or lactating females
* Patients undergoing surgery as form of palliative cancer therapy
* Presence or history of severe extra-hepatic diseases
* HIV-positive patients
* Previous liver or other transplantation
* Patients with acute or subacute liver failure without underlying cirrhosis
* Patients who decline to participate
* Physician´s denial (e.g. the investigator considers that the patient will not follow the protocol scheduled)

Where it's running

• University Hospital Bonn
  Bonn, Germany Recruiting

Study contacts

• Principal investigator: Michael Praktiknjo, MD — University Hospital, Bonn
• Study coordinator: Michael Praktiknjo, MD
• Email: michael.praktiknjo@ukbonn.de
• Phone: +4922828716375

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Registry for patients undergoing TIPS implantation for portal hypertension

  This study is collecting information from patients with serious portal hypertension who are getting a TIPS procedure to see how well it works and what complications might happen afterward.

  Recruiting University Hospital Freiburg · Freiburg im Breisgau · NCT05782556

• Coil-assisted small-diameter stent shunt reduction for refractory HE after TIPS

  A coil-assisted, small-diameter covered-stent technique is being tested to see if it can safely and effectively reduce shunt flow and lessen recurrent hepatic encephalopathy in people with a prior TIPS.

  Recruiting Air Force Military Medical University, China · Xi'an, Shaanxi · NCT07799948

• Austrian PBC Registry

  This registry follows adults with primary biliary cholangitis in Austrian centers to see how the disease develops over time and how biomarkers relate to complications and symptoms.

  Recruiting Medical University of Vienna · Klagenfurt, Carinthia and 10 other locations · NCT07598669

• Blood clotting and portal vein changes during TIPS placement in cirrhosis

  This project will see how blood clotting in the body and in the portal vein changes in adults with cirrhosis who are having a TIPS placed.

  Recruiting Assistance Publique - Hôpitaux de Paris · Villejuif · NCT07439939

• Comparing HVPG and endoscopic ultrasound portal pressure measurements

  This study will test whether an endoscopic ultrasound method (EUS-PPG) gives the same portal pressure readings as the standard hepatic venous pressure gradient (HVPG) in adults who need portal pressure measurement.

  Recruiting at 2 sites Military University Hospital, Prague · Prague, Bohemia and 1 other locations · NCT07424963

• Handgrip strength and portal vein blood flow in people with liver cirrhosis

  This trial will test whether squeezing a handgrip changes portal vein and left gastric vein pressures and blood flow in adults with liver cirrhosis to see if muscle strength affects variceal hemodynamics.

  Recruiting at 2 sites Shanxi Provincial People's Hospital · Luoyang, Henan and 1 other locations · NCT07116096

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.