Using Holmium-166 radioembolization to treat liver cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and effectiveness of Holmium-166 (Ho-166) transarterial radioembolization (TARE) for patients with locally advanced hepatocellular carcinoma (HCC). It focuses on patients diagnosed with HCC who received Ho-166 TARE treatment between January 2010 and December 2024. The research involves a retrospective analysis of patient records, examining demographics, tumor characteristics, treatment side effects, and survival outcomes. The goal is to determine if this targeted radiation therapy can improve treatment outcomes for liver cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* aged 18 year or older
* diagnosed with locally advanced HCC without extra-hepatic metastases
* HCC must not be amendable to treatment by surgical resection or percutaneous radiofrequency ablation
* after assessment by the investigator and multidisciplinary tumor board, the patient is considered suitable for protocol treatment with Holmium-166 TARE
* ECOG performance status 0-2
* child-Pugh A-B
* tumor response evaluable with mRECIST criteria during follow-up

Exclusion Criteria:

* prior treatment with any of the following treatment modalities for HCC: systemic therapy, hepatic radiation therapy
* currently enrolled in clinical studies where patient receive investigational therapeutic drug
* metastatic disease
* concurrent malignancy
* active contra-indications to angiography or selective catherization (i.e. severe vascular disease or bleeding diathesis)
* uncontrolled and/or severe comorbidities (active infection, heart failure,...) with limited estimated life expectancy
* history of or know allergic reactions to used compounds

Where it's running

• UZ Brussel
  Brussels, Belgium Recruiting

Study contacts

• Study coordinator: Helena Degroote
• Email: Helena.Degroote@uzbrussel.be
• Phone: 02476 3308

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.