Understanding and preventing complications of liver cirrhosis
Official title: Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
Funded at University of California, San Francisco · NIH-10909255 · Data updated 2026-11-12
This study is looking for ways to help people with cirrhosis, a serious liver condition, by finding better treatments and understanding how things like race and lifestyle can affect their health, especially for those at higher risk.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 6, 2021 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $393,577 |
| NIH project number | 5U01DK130168-04 |
| Project ID | NIH-10909255 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cirrhosis, particularly those from high-risk groups such as racial/ethnic minorities and those with substance use disorders.
✕Less likely to help
Patients with early-stage liver disease or those without cirrhosis may not receive direct benefits from this research.
What this research studies
This research focuses on the rising prevalence of cirrhosis, a severe liver condition that leads to significant health issues and mortality. It aims to identify effective preventative measures, including treatment of underlying liver diseases and monitoring for complications. The study will also explore the impact of social determinants of health on cirrhosis outcomes, particularly in high-risk populations such as racial/ethnic minorities and individuals with substance use disorders. By investigating potential therapies and risk factors, the research seeks to improve survival rates and quality of life for patients with cirrhosis.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing complications associated with liver cirrhosis, ultimately enhancing patient survival and quality of life.
How similar studies have gone: Previous research has shown promise in understanding and managing complications of liver diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Khalili, Mandana — University of California, San Francisco
- Study coordinator: Khalili, Mandana
Related research
Other NIH-funded projects on the same topics.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
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Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial
This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.
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First-in-class treatment for liver cirrhosis with portal hypertension
A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.