How liver failure, fibrosis, and low inorganic pyrophosphate contribute to artery calcification in people awaiting liver transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls people who require liver transplantation for chronic liver disease and collects blood and urine samples around the time of transplant. Investigators will measure plasma inorganic pyrophosphate (PPi) levels and monitor markers of arterial calcification before and after transplantation to determine whether PPi is restored and calcification progression is altered. Patients with very high short-term mortality risk (MELD >25) or active viral replication are excluded. The design uses transplant as a physiologic intervention to link hepatic function, PPi metabolism, and vascular calcification.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* everyone requiring liver transplantation for the treatment of a chronic liver disease

Exclusion Criteria:

* MELD score \>25, viral replication

Where it's running

• CHU de Nice
  Nice, Alpes-maritimes, France Recruiting

Study contacts

• Principal investigator: Guillaume FAVRE, PhD — CRC, Néphrologie - CHU de Nice - Hôpital de l'Archet
• Study coordinator: Guillaume FAVRE, PhD
• Email: favre.g@chu-nice.fr
• Phone: +33492039220

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.