Condition

Hepatitis B clinical trials and research

• 25Clinical trials
• 91NIH research projects
• 11Countries

Newest Hepatitis B clinical trials

All recruiting trials (25)

• Entecavir 0.5 mg vs 1.0 mg daily in adults with HBV-related decompensated cirrhosis

  This trial tests whether 0.5 mg or 1.0 mg of entecavir once daily can better lower HBV DNA in adults with HBV-related decompensated cirrhosis over 24 weeks.

  Recruiting Phase 4 Bangladesh Medical University · Dhaka, Dhaka Division · NCT07816094

• Hepatitis B in Zambia: an observational cohort of adults with HBV, with or without HIV

  This observational cohort follows adults diagnosed with hepatitis B in Zambia, with and without HIV coinfection, to see how their liver disease and HBV (and HIV when present) change over several years while they receive standard care.

  Recruiting at 3 sites University of Alabama at Birmingham · Lusaka and 2 other locations · NCT07589985

• Long-term outcomes of pegylated interferon alfa-2b in families with clustered hepatitis B and high risk of cirrhosis or liver cancer

  This study will try pegylated interferon alfa-2b to see if it improves long-term outcomes for people with chronic hepatitis B from families where cirrhosis or liver cancer affects two generations.

  Recruiting First Affiliated Hospital Xi'an Jiaotong University · Xi'an, Shaanxi and 1 other locations · NCT07079150

• Comparing two treatments to prevent hepatitis B transmission from mothers to infants

  This study is testing whether two different antiviral treatments can help prevent pregnant women with high hepatitis B levels from passing the virus to their babies.

  Recruiting Guangzhou 8th People's Hospital · Guangzhou, Guangdong and 9 other locations · NCT06947356

• Untreated or Unknown HBV, HDV, and HCV in South-East Austria: See if People Need Care

  This study looks at past test results to see how many people in South-East Austria have hepatitis B, hepatitis D coinfection, or hepatitis C that hasn’t been treated yet or isn’t known, and then invites them for care.

  Recruiting Medical University of Graz · Graz, Styra · NCT06834178

• Monoclonal antibody treatment for chronic hepatitis B

  This study is testing a new monoclonal antibody treatment for people with chronic hepatitis B to see if it can help clear the virus and possibly allow them to stop their long-term antiviral medications.

  Recruiting Phase 1 University of Aarhus · Aarhus N · NCT06668727

• Comparing ultrasound and biomarker screening for liver cancer in patients with cirrhosis or hepatitis B

  This study is testing whether ultrasound or a blood test is better at finding liver cancer early in people with cirrhosis or chronic hepatitis B.

  Recruiting at 18 sites Phase 4 University of Texas Southwestern Medical Center · Los Angeles, California and 18 other locations · NCT06084234

• Achieving a functional cure for hepatitis B in patients with HIV and hepatitis B co-infection

  This study is testing if adding interferon to standard HIV treatment can help people who have both HIV and hepatitis B clear the virus from their system.

  Recruiting Guangzhou 8th People's Hospital · Guangzhou, Guangdong · NCT05988879

• Follow-up of patients with decreased HBsAg levels in chronic hepatitis B

  This study is tracking people with chronic hepatitis B who have lower HBsAg levels to see how their treatment affects their condition over three years.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT05977283

• Evaluating the safety and effectiveness of I.V.-Hepabig for post-liver transplant patients with Hepatitis B

  This study tests if a new treatment called I.V.-Hepabig can safely help liver transplant patients who had Hepatitis B by preventing the virus from coming back.

  Recruiting at 8 sites Phase 3 GC Biopharma Corp · Goyang-si, Gyeonggi-do and 7 other locations · NCT05686759

• Screening for hepatitis B, hepatitis C and HIV using a dried blood spot

  This project will try a simple dried blood spot test to check people who use drugs for hepatitis B, hepatitis C and HIV.

  Recruiting at 11 sites University Hospital, Rouen · Avranches and 10 other locations · NCT05390424

• Collecting blood samples from healthy individuals and patients with cancer or benign diseases

  This study is collecting blood samples from healthy people and patients with cancer or non-cancer conditions to see if certain DNA markers can help detect cancer more accurately.

  Recruiting at 6 sites Helio Genomics · Redondo Beach, California and 6 other locations · NCT05181826

• Revaccination doses of hepatitis B vaccine for young adults

  This study tests the best way to give the hepatitis B vaccine to young adults in Taiwan who are at high risk and don't have enough protection against the virus.

  Recruiting National Taiwan University Hospital · Taipei, Taipei · NCT04970836

• Assessment of people living with chronic hepatitis B in Australia

  This study is looking to understand the care and treatment needs of people living with chronic hepatitis B in Australia by collecting information from those who have visited clinics for their condition.

  Recruiting at 15 sites Kirby Institute · Sydney, New South Wales and 18 other locations · NCT04914611

• HEPLISAV-B (TLR‑9 adjuvanted) vaccine for adults with chronic hepatitis B

  This trial will try giving two HEPLISAV-B vaccine shots to adults with chronic hepatitis B who are virally suppressed on antiviral therapy to see if the vaccine is safe and how it affects their immune cells.

  Recruiting Phase 1 University of Maryland, Baltimore · Baltimore, Maryland · NCT04843852

• Comparing 2-dose and 3-dose hepatitis B vaccine regimens in cirrhosis patients

  This study is testing whether giving two or three doses of the hepatitis B vaccine works better for people with cirrhosis who need protection against the virus.

  Recruiting Phase 4 Mercy Medical Center · Baltimore, Maryland · NCT04588077

• How chronic liver diseases connect with other long-term illnesses

  We will look back at hospital records to see if chronic liver diseases are linked with other systemic illnesses in adults who visited Tzu Chi gastroenterology clinics.

  Recruiting Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation · New Taipei City · NCT04525833

• Long-term outcomes for patients recovering from hepatitis B related liver failure

  This study looks at the long-term health and recovery of people who have survived liver failure caused by hepatitis B to see how they are doing over time.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT04310787

• Comparing Tenofovir Alafenamide and Entecavir for Chronic Hepatitis B Treatment

  This study is testing whether a newer hepatitis B medication called tenofovir alafenamide works as well as an older one called entecavir, while also being safer for the kidneys.

  Recruiting Phase 4 Taichung Veterans General Hospital · Taichung, Taichung · NCT03933384

• Treatment of Hepatitis B Related Acute-On-Chronic Liver Failure with Nucleotide/Nucleoside Analogues

  This study is testing if three antiviral medications can help people with hepatitis B-related liver failure feel better and improve their chances of recovery.

  Recruiting Third Affiliated Hospital, Sun Yat-Sen University · Guangzhou, Guangdong · NCT03920618

• Using stem cells to treat hepatitis B cirrhosis

  This study is testing whether stem cells can help improve the health of adults with severe liver damage from hepatitis B cirrhosis.

  Recruiting Phase 1 Sclnow Biotechnology Co., Ltd. · Changsha, Hunan · NCT03826433

• Creating a cohort to study viral RNAs as a new biomarker for hepatitis B cure.

  This study is trying to see if measuring certain viral RNAs in blood samples can help find a new way to tell if people with hepatitis B are getting closer to a cure.

  Recruiting at 3 sites Hospices Civils de Lyon · Lyon and 5 other locations · NCT03825458

• Biorepository for liver disease samples

  This study is collecting samples from patients with liver diseases to help researchers find better treatments and improve care for these conditions.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT03025074

• Registry to monitor the effects of antiretroviral drugs during pregnancy

  This study is trying to see if certain HIV medications taken during pregnancy can cause any serious problems for the baby.

  Recruiting Syneos Health · Wilmington, North Carolina · NCT00404989

• Evaluation of patients with liver disease

  This study is trying to learn more about liver diseases by checking in on patients with conditions like hepatitis B, C, and D through regular tests and follow-ups.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00001971

NIH-funded research (newest 40 of 91)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• HBV cure clues in people with and without HIV

  This project studies how HBV-specific B and T cell responses relate to curing hepatitis B in people with and without HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11600326

• HBV cure factors in people with and without HIV

  This project studies how HBV-specific immune cells behave during treatment and whether people with HIV respond differently than those without HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11600298

• HBV prevention in community pharmacies: a first step in a low-resource setting

  This pilot project tests whether hepatitis B screening and vaccination can be integrated into everyday community pharmacy services to reach more people.

  NIH research University of North Texas Hlth Sci Ctr · Fort Worth, United States · NIH-11473743

• Blood markers to catch early liver cancer in Hispanic people with hepatitis B

  This project will see if a blood test can find liver cancer earlier in Hispanic people who have chronic hepatitis B.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11473605

• Early blood markers to find hepatitis B–related liver cancer in Hispanics

  This project will use immune-related blood markers to find liver cancer earlier in people with chronic hepatitis B, focusing on Hispanic adults.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11473604

• HBV safety with long-acting HIV therapy for people with HIV

  A study to understand how long-acting HIV meds affect hepatitis B in people living with HIV and how to best monitor and protect them.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11470595

• Antiviral Therapy and HBV DNA Integration in Chronic Hepatitis B

  This project looks at how existing HBV drugs may influence the way HBV DNA becomes integrated into the liver cells’ DNA in people with chronic hepatitis B.

  NIH research Baruch S. Blumberg Institute · Doylestown, United States · NIH-11439278

• Hepatitis B and HIV Cure Consortium (BICC) to help people with HIV and hepatitis B

  A multinational effort will follow people who have both HIV and hepatitis B to find ways that could lead to a cure that stops the virus while people are off treatment.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11423432

• HBV and HIV Cure Cohort for a Functional HBV Cure

  A multinational group will enroll people living with HIV and chronic hepatitis B to study new technologies that could lead to a functional cure for HBV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11423431

• Hepatitis B and HIV Cure Network

  A multinational group is gathering people with HIV and chronic hepatitis B to study new ideas that could lead to a functional cure for hepatitis B.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11423430

• Hepatitis B and HIV Cure Network to help people with HIV and hepatitis B

  A multinational effort to study why some people with HIV and chronic hepatitis B may eventually lose hepatitis B surface antigen and achieve a functional cure.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11423429

• HBV cure signals in people with and without HIV

  This project studies how HBV-specific immune responses differ in people with HIV compared to those without HIV who are being treated for hepatitis B, with the aim of understanding what parts of the immune system help achieve a cure.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11419816

• Hepatitis B and HIV Cure Consortium: building a global effort to find a functional cure for HBV in people with HIV

  A wide, international effort is gathering people with HIV and hepatitis B to study and share samples and data in the search for a functional cure for HBV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11419732

• HBV immune responses in functional cure and therapies guided by CD4 T cells and B cells

  This grant studies how HBV-specific CD4 T cells and B cells behave in people with hepatitis B to identify clues for achieving a functional cure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11418540

• Therapeutic nucleic acid vaccine for chronic hepatitis B in people with HIV/HBV co-infection

  A new genetic vaccine approach is being tested to help people living with both HIV and chronic hepatitis B reduce and potentially cure their HBV infection.

  NIH research Orlance, INC. · Seattle, United States · NIH-11415128

• HBV immune responses and pathways linked to functional cure

  Researchers will study how HBV-specific CD4 T cells and B cells behave in people with chronic hepatitis B to find what immune changes are needed for a functional cure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11414993

• Nanobodies to help clear HBV surface antigen and restore immunity

  A small, targeted antibody therapy using nanobodies is being explored to lower hepatitis B surface antigen in people with chronic HBV, with the goal of helping the immune system clear the infection.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11391645

• How immune cells help control chronic hepatitis B

  This research looks at how two immune cell types (CD4 T cells and B cells) in adults with hepatitis B act differently in people who clear the virus versus those with long-term infection to find clues for treatments that could lead to a functional cure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11388070

• Hamster model to study hepatitis B virus infection

  A researcher is creating a hamster-based model to study how hepatitis B virus infects and persists in the liver, with the goal of helping develop better treatments and cures.

  NIH research Utah State University · Logan, United States · NIH-11385270

• HBV integrations in KMT2B may drive liver cancer

  Aims to understand how hepatitis B can cause liver cancer by studying HBV inserts in the KMT2B gene and how these changes affect liver cells.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11370878

• Host-targeted antiviral to achieve a functional cure for chronic hepatitis B

  A research project tests a new drug strategy that aims to clear signs of hepatitis B in people who have a chronic infection.

  NIH research Evrys Bio, INC. · Doylestown, United States · NIH-11364197

• Developing woodchucks that can be infected with hepatitis B by tweaking the virus or the host

  Researchers at Georgetown University are exploring new ways to make woodchucks susceptible to hepatitis B infection to better study the virus and test future treatments.

  NIH research Georgetown University · Washington, United States · NIH-11361668

• Hepatitis B vaccine effects on immune responses and HIV reservoir in people with HIV

  This grant studies how a Hepatitis B vaccine with a special adjuvant works in people living with HIV to boost protection against HBV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11333315

• New mouse models to study hepatitis B infection and replication

  A researcher team will create and study new mouse models to understand how hepatitis B virus infects the liver and replicates, with the goal of informing better treatments for people living with HBV.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11318919

• Long-acting injectable hepatitis B antivirals with an immune booster

  This project is developing long-lasting injectable hepatitis B medicines combined with an immune stimulant for people living with chronic hepatitis B.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11317188

• How hepatitis B spreads from mothers to their babies

  This research looks at how a mother's hepatitis B infection changes her baby's immune response and can lead to long-term infection.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11310804

• How the hepatitis B ‘e’ antigen helps the virus persist in the liver

  This research explains how a hepatitis B protein called HBeAg changes liver immune cells in ways that help the virus survive long-term, with the goal of helping people with chronic hepatitis B.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11294163

• How alcohol weakens liver immune defenses and worsens Hepatitis B

  This project looks at how alcohol and high‑fat diets weaken liver immune signals so hepatitis B can stick around longer and cause more damage in people with HBV.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11261152

• Blood test to detect early liver cancer in Hispanic people with hepatitis B

  This project looks at whether a blood-based panel of immune markers can find early liver cancer in Hispanic adults who have chronic hepatitis B.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11258005

• How antibodies help control hepatitis B in people with and without HIV

  This project looks at whether antibody responses help people with hepatitis B — including those who also have HIV — control or clear the infection.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11235131

• Improving diagnostic tests for Hepatitis B

  This study is working on creating faster and more reliable tests for Hepatitis B, so patients can get easier access to testing and start treatment sooner.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11205649

• Improving diagnostic tests for Hepatitis B

  This study is working on new, easy-to-use tests for Hepatitis B that can give you results faster and help you get the care you need more quickly, making it easier for patients to get diagnosed and treated.

  NIH research Emory University · Atlanta, United States · NIH-11205647

• Improving diagnostic tests for Hepatitis B

  This study is working to make better and faster tests for Hepatitis B, so patients can get diagnosed more easily and quickly, improving their overall healthcare experience.

  NIH research Venturewell · Hadley, United States · NIH-11205626

• A new biosensor for detecting HIV and Hepatitis viruses in low-resource areas

  This study is working on a new, easy-to-use test that can quickly check for HIV, Hepatitis B, and Hepatitis C all at once, especially in places where medical resources are limited, to help more people get diagnosed and treated sooner.

  NIH research University of Central Florida · Orlando, United States · NIH-11187332

• Removing the persistent hepatitis B DNA in people with both hepatitis B and HIV

  Trying a viral gene-delivery method to remove the persistent hepatitis B DNA (cccDNA) in people living with both hepatitis B and HIV.

  NIH research Princeton University · Princeton, UNITED STATES · NIH-11173635

• A new way for patients to test themselves for HIV and Hepatitis B

  This study is working on a simple and affordable device that lets people easily test themselves for HIV and Hepatitis B using just a drop of blood from their finger, making it easier for everyone, especially those in underserved areas, to get important health information and catch these infections early.

  NIH research Baebies, INC. · Durham, United States · NIH-11170207

• Finding why some adults don't make strong antibodies after hepatitis B shots

  This project looks for blood immune markers that explain why some adults, especially those with obesity, make weak antibody responses after hepatitis B vaccination.

  NIH research New York University School of Medicine · New York, United States · NIH-11169898

• Hamster model to help advance hepatitis B treatments

  Researchers are building a hamster-based system to better mimic hepatitis B infection and help develop cures for people with chronic HBV.

  NIH research Utah State University · Logan, United States · NIH-11166378

• Understanding how different hepatitis B vaccines affect immune responses in people living with HIV

  This study is looking at how well two different hepatitis B vaccines work for people living with HIV, comparing the usual vaccine, ENGERIX-B, with a newer one, HEPLISAV-B, to see if the new vaccine offers better protection.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11144593

• Understanding how Hepatitis B causes liver cancer

  This research explores how the Hepatitis B virus changes a specific gene to cause liver cancer, hoping to find new ways to help patients.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11143851

Related topics

Quick answers

How many Hepatitis B clinical trials are recruiting right now?

25, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 11 countries. The most sites are in China (7 trials), United States (7 trials), Taiwan (3 trials), France (2 trials), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 1: 3, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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