Condition

Hepatic Encephalopathy clinical trials and research

• 14Clinical trials
• 5NIH research projects
• 9Countries

Newest Hepatic Encephalopathy clinical trials

All recruiting trials (14)

• Coil-assisted small-diameter stent shunt reduction for refractory HE after TIPS

  A coil-assisted, small-diameter covered-stent technique is being tested to see if it can safely and effectively reduce shunt flow and lessen recurrent hepatic encephalopathy in people with a prior TIPS.

  Recruiting Air Force Military Medical University, China · Xi'an, Shaanxi · NCT07799948

• Fecal transplant plus standard therapy for refractory hepatic encephalopathy after TIPS

  This study tests whether adding fecal microbiota transplantation to usual medicines helps people with recurrent hepatic encephalopathy after TIPS implant.

  Recruiting Early Phase 1 Air Force Military Medical University, China · Xi'an · NCT07683936

• Apixaban plus carvedilol to prevent portal-hypertension complications in cirrhosis

  This will test whether adding apixaban to carvedilol can help prevent variceal bleeding, portal vein thrombosis, and other portal-hypertension complications in adults with Child-Pugh B cirrhosis.

  Recruiting Phase 4 Asian Institute Of Medical Sciences · Hyderābād, Sindh · NCT07521332

• Developing and testing the Liver Cirrhosis Cognitive Decline Scale (LiCCoS)

  This project will test a short questionnaire called LiCCoS to see if it can spot thinking and everyday mental problems in adults with liver cirrhosis.

  Recruiting University of Malaya · Ambāla, Haryana · NCT07418008

• Melatonin to improve sleep and thinking in people with cirrhosis

  This study will try one month of daily melatonin (compared with one month of thiamine) to see if it improves sleep and thinking in adults with cirrhosis and hepatic encephalopathy.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT07046429

• Examining the link between serum albumin levels and hepatic encephalopathy severity in chronic liver disease patients

  This study is trying to see if the level of a protein called serum albumin in the blood is related to how severe brain problems are in people with chronic liver disease.

  Recruiting Sohag University · Sohag · NCT06953921

• Using inhaled amikacin to prevent pneumonia in cirrhosis patients on ventilators

  This study is testing if inhaled amikacin can help prevent pneumonia in patients with cirrhosis who are on ventilators.

  Recruiting at 2 sites Phase 4 Asian Institute of Gastroenterology, India · Hyderabad, Telangana and 1 other locations · NCT06808074

• Comparing BCAA and Rifaximin for Preventing Hepatic Encephalopathy Recurrence

  This study is testing whether taking branched-chain amino acids or rifaximin can help people who have recently recovered from liver-related brain issues avoid having those problems come back.

  Recruiting Phase 4 Post Graduate Institute of Medical Education and Research, Chandigarh · Chandigarh · NCT06538077

• Using resistant potato starch to treat cirrhosis and hepatic encephalopathy

  This study is testing if eating resistant potato starch can help improve gut health and symptoms in people with cirrhosis and hepatic encephalopathy.

  Recruiting at 2 sites Mayo Clinic · Rochester, Minnesota and 1 other locations · NCT06425380

• Using Nitazoxanide to prevent recurrence of hepatic encephalopathy

  This study is testing if a medication called Nitazoxanide can help prevent cirrhotic patients from having more episodes of hepatic encephalopathy when used with another drug called Rifaximin.

  Recruiting Phase 3 Tanta University · Tanta · NCT04161053

• Protein supplement to reduce hospital readmissions for liver disease patients

  This study is testing if a protein supplement can help liver disease patients who have had hospital stays for brain issues feel better and avoid going back to the hospital.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT04096014

• Preventing liver complications after TIPS placement with rifaximin and lactulose

  This study is testing if taking rifaximin and lactulose can help prevent brain problems in adults with liver cirrhosis after they have a procedure called TIPS.

  Recruiting at 6 sites Phase 4 Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Leuven and 5 other locations · NCT04073290

• Using fecal microbiota transplantation to treat gut disorders

  This study is testing whether a treatment that involves using healthy stool to help restore gut bacteria can improve symptoms for people with gut disorders like Crohn's disease and irritable bowel syndrome.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04014413

• Observational study on advanced chronic liver diseases in Vienna

  This study looks at patients with advanced chronic liver diseases in Vienna to see how their condition affects blood pressure in the liver and to collect samples for future research.

  Recruiting Medical University of Vienna · Vienna · NCT03267615

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cholesterol and brain health in liver cirrhosis leading to hepatic encephalopathy

  Researchers will study how cholesterol in the brain may contribute to brain problems seen in people with liver cirrhosis and hepatic encephalopathy.

  NIH research University of Texas at Austin · Austin, United States · NIH-11394432

• POEM: a pharmacist-led plan to optimize liver-bleed HE management

  A pharmacist-driven program helps people with hepatic encephalopathy manage lactulose use and safely reduce unnecessary medications to improve thinking and reduce hospital stays.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11342776

• How cholesterol affects brain problems from cirrhosis

  This research looks at whether cholesterol builds up in the brain and changes neurosteroids, contributing to hepatic encephalopathy in adults with liver cirrhosis.

  NIH research University of Texas at Austin · Austin, United States · NIH-11182574

• Investigating how gut bacteria affect brain function in liver disease

  This study is looking at how gut bacteria might affect brain function in people with liver disease, specifically those with and without symptoms of hepatic encephalopathy, to find new ways to help improve their health.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11166551

• Investigating how cholesterol affects brain function in liver disease

  This study is looking at how cholesterol levels in the brain might affect brain problems in people with liver cirrhosis, hoping to find new ways to help those who are dealing with these serious issues.

  NIH research University of Texas at Austin · Austin, United States · NIH-10812086

Related topics

Quick answers

How many Hepatic Encephalopathy clinical trials are recruiting right now?

14, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in India (3 trials), United States (3 trials), China (2 trials), Egypt (2 trials), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Early Phase 1: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →