Condition

End Stage Liver Disease clinical trials and research

• 13Clinical trials
• 2NIH research projects
• 6Countries

Newest End Stage Liver Disease clinical trials

All recruiting trials (13)

• Even protein distribution plus exercise for people awaiting liver transplant

  This trial tests whether spreading daily protein evenly and combining it with a 12-week exercise program improves nutrition, muscle mass, and function in people waiting for a liver transplant compared with uneven protein timing or usual advice.

  Recruiting at 2 sites Agricultural University of Athens · Athens, Attica and 1 other locations · NCT07561138

• Preoperative Carbohydrate Loading Before Liver Transplant

  This study tests whether drinking a carbohydrate beverage before anesthesia helps liver transplant patients recover faster.

  Recruiting Medical University of Warsaw · Warsaw · NCT07519057

• Frailty, Nutrition, and Recovery in People Waiting for a Liver Transplant

  This project will test whether measures of frailty, muscle loss, nutrition, and psychological health can predict outcomes for adults (18–65) on the liver transplant waiting list in Turkey.

  Recruiting Izmir Bakircay University · Izmir · NCT07414095

• Train the immune system to accept a living-donor liver so you may stop lifelong anti-rejection drugs

  This test gives donor stem cells plus a short conditioning treatment to people with HLA-matched living-donor liver transplants to see if they can safely stop long-term immunosuppressive drugs.

  Recruiting Phase 1/2 University of California, Los Angeles · Los Angeles, California · NCT07269041

• Using Siplizumab to prevent immune issues in liver transplant patients with autoimmune liver disease

  This study is testing if a new medication called siplizumab can help prevent immune problems in adults with autoimmune liver disease who are getting a liver transplant.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06455280

• Observational study on liver transplantation using hypothermic oxygenated machine perfusion

  This study looks at how well a new method of preserving livers with a special machine helps patients who are getting liver transplants at the Medical University of Vienna.

  Recruiting Medical University of Vienna · Vienna · NCT06418165

• Using spleen stiffness measurement to predict outcomes in liver disease patients with acute liver injury

  This study is testing if measuring spleen stiffness can help predict how patients with chronic liver disease and acute liver injury will do in the short term.

  Recruiting Nanfang Hospital, Southern Medical University · Guangzhou, Guangdong · NCT06173947

• Exploring muscle composition's impact on liver transplant outcomes

  This study is testing how muscle health affects the success of liver transplants in patients with severe liver disease.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT05477277

• Hepatology home hospital program for people with advanced liver disease

  This will try a hospital-at-home program that brings hepatology care to adults with cirrhosis who would otherwise need inpatient care.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT05205954

• Transplanting liver cells into lymph nodes for treating severe liver disease

  This study is testing if putting liver cells into lymph nodes can help people with severe liver disease feel better and improve their liver function.

  Recruiting Phase 2 LyGenesis, Inc. · Boston, Massachusetts and 1 other locations · NCT04496479

• Exploring end-stage liver disease in China

  This study looks at how end-stage liver disease is currently being diagnosed and treated in China to see if better methods can help patients with liver cirrhosis and its complications.

  Recruiting Huashan Hospital · Shanghai, Shanghai Municipality · NCT04037995

• Using social media to find live organ donors for patients in need

  This study is testing if using social media to share stories can help patients waiting for organ transplants find live donors more easily.

  Recruiting Johns Hopkins University · San Diego, California and 5 other locations · NCT03803423

• Assessing functional health in patients awaiting liver transplants

  This study is trying to see how frailty and overall health affect people waiting for liver transplants by tracking their physical and mental abilities over a year.

  Recruiting at 8 sites University of California, San Francisco · Little Rock, Arkansas and 11 other locations · NCT03228290

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how liver failure happens and how key transcription factors could restore liver function

  A research project aims to understand why end-stage liver disease worsens and whether fixing certain transcription factors can help the liver regain function.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11447691

• Novel HNF4α-based nucleotide therapy for end-stage liver disease with cirrhosis

  A new therapy using a nucleotide-LNP to restore a key liver gene could improve liver function and survival for people with severe cirrhosis or liver failure.

  NIH research Masterswitch, INC. · Wilmington, France · NIH-11408899

Related topics

Quick answers

How many End Stage Liver Disease clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (7 trials), China (2 trials), Austria (1 trial), Greece (1 trial), Turkey (Türkiye) (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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