Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
Official title: Liver Cirrhosis Network: Clinical Research Center - Mayo Clinic
Funded at Mayo Clinic Rochester · NIH-11591514 · Data updated 2026-11-12
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | September 13, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $397,500 |
| NIH project number | 5U01DK130181-06 |
| Project ID | NIH-11591514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with compensated cirrhosis who can participate in observational data collection and the statin trial.
✕Less likely to help
Patients who do not have compensated cirrhosis or have contraindications to statins may not benefit.
What this research studies
This project will collect detailed clinical, lab, and imaging data from patients with compensated cirrhosis across multiple centers to build a rich database. It will develop an AI-based algorithm to predict cirrhosis decompensation using medical records, tests, and imaging like MR elastography and ECG. At the same time, the study will conduct a large randomized trial to see if simvastatin can reduce complications and improve survival. The initiative combines observational research with translational aims to identify new targets and therapies for cirrhosis.
Why it matters
Potential benefit: If successful, patients with cirrhosis could benefit from earlier prediction of complications and a potential new therapy to improve outcomes.
How similar studies have gone: Previous research suggests statins may help liver function and portal hypertension, but definitive trials are needed.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Shah, Vijay H. — Mayo Clinic Rochester
- Study coordinator: Shah, Vijay H.
Related research
Other NIH-funded projects on the same topics.
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Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
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Liver Cirrhosis Network: Longitudinal and Clinical Trial Studies
A network-wide NIH study focused on understanding cirrhosis better to prevent complications and improve care for people with advanced liver disease.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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Liver Cirrhosis Network coordinating cirrhosis studies and a rosuvastatin trial
This project follows people with liver cirrhosis over time and tests whether the cholesterol medicine rosuvastatin helps people with cirrhosis.
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First-in-class treatment for liver cirrhosis with portal hypertension
A new therapy called XFB19 aims to reduce liver inflammation and scarring in people with advanced liver disease and portal hypertension.
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Liver cirrhosis network coordinating treatments and patient data
This program brings hospitals together to run and organize tests of treatments and care approaches for people living with liver cirrhosis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.