Sponsor or institution

Clinical trials and research at University of Southern California

• 84Clinical trials
• 1056NIH research projects
• 7Countries

Newest trials

All recruiting trials (84)

• Stroke Volume–Based Fluid Resuscitation in Acute Pancreatitis

  This trial tests whether adjusting IV fluids based on each patient’s stroke volume helps people with acute pancreatitis avoid fluid overload while staying well hydrated.

  Recruiting University of Southern California · Los Angeles, California and 1 other locations · NCT07756476

• Social media messages and how they affect teens’ interest in non-combustible tobacco products

  This study tests social media posts showing flavors and stealth use to see if they raise teens’ interest and likelihood to try non-combustible tobacco products.

  Recruiting University of Southern California · Los Angeles, California · NCT07721883

• Tactile Pre-Visit Imagery for Reducing Dental Anxiety in Young Children

  This study tests whether a tactile pre-visit imagery booklet can reduce anxiety and improve behavior in 4- to 10-year-olds needing their first dental restoration.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT07719205

• Do a single nicotine pouch affect cigarette craving and brain response to smoking cues

  This study tests whether a single 6 mg oral nicotine pouch can reduce craving and alter prefrontal brain responses to smoking cues in adults who smoke cigarettes.

  Recruiting University of Southern California · Los Angeles, California · NCT07698470

• Tirzepatide for Smoking Cessation in people who smoke and are overweight or obese

  This study tests whether tirzepatide can help adults who smoke quit and manage weight better than placebo when combined with usual smoking-cessation support.

  Recruiting at 4 sites Phase 2 University of Southern California · Los Angeles, California and 3 other locations · NCT07602699

• K-Savvy: Supporting Korean American Dementia Caregivers Online

  A online program called K-Savvy helps Korean American caregivers of loved ones with dementia manage stress and depression.

  Recruiting University of Southern California · Los Angeles, California · NCT07550075

• Empowering discipline-referred middle-school students to be peer coaches

  The program will try Peer Coach Training with middle-school students who received discipline referrals to see if helping peers reduces disruptive behavior and improves school engagement.

  Recruiting University of Southern California · Los Angeles, California · NCT07515742

• Continuous glucose monitoring plus AI video coaching for adults with prediabetes

  This project will try combining a wearable continuous glucose monitor with daily AI-generated education videos to see if it helps adults with prediabetes improve their blood sugar over 20 days.

  Recruiting University of Southern California · Los Angeles, California · NCT07477249

• MoodBrush app versus parent-modeled toothbrushing for children ages 3-6

  This test will see if the MoodBrush app helps children ages 3-6 remove as much plaque as brushing modeled by a parent.

  Recruiting University of Southern California · Los Angeles, California · NCT07441148

• Personalized AI-driven robot companions to support CBT for anxiety in college students

  This test tries whether personalized AI-driven robot companions can help college students with anxiety stick to CBT exercises and reduce symptoms.

  Recruiting University of Southern California · Los Angeles, California · NCT07430800

• Patient experiences and preferences for IV versus subcutaneous immunotherapy in non-small cell lung cancer

  This survey asks people with non-small cell lung cancer who are receiving immune checkpoint inhibitors whether they prefer IV treatment or subcutaneous injections at the hospital or at home.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT07339254

• Culturally tailored patient navigation to shorten time from cancer diagnosis to treatment for American Indian and Alaska Native people in rural California

  This project will try a culturally tailored patient navigation program to shorten delays between cancer diagnosis and treatment for American Indian and Alaska Native adults living in rural California.

  Recruiting at 2 sites University of Southern California · Bishop, California and 1 other locations · NCT07332312

• Social and healthcare factors behind late-stage liver cancer in low-income neighborhoods

  This project will try to find which social and medical barriers keep adults in low-income areas of Los Angeles from getting early diagnoses of liver cancer.

  Recruiting University of Southern California · Los Angeles, California · NCT07312162

• Interest in integrative oncology services at USC Norris Cancer Center

  This project will see if adult patients with solid tumors or blood cancers at USC Norris and Keck HC3 are interested in and able to use integrative oncology services and what barriers might limit participation.

  Recruiting University of Southern California · Los Angeles, California · NCT07306338

• GYN-AIDE: AI-Driven Education to Help Gynecologic Cancer Patients

  This study tests an AI chatbot to help endometrial cancer patients learn about care and HPV vaccination, and to see if using the chatbot influences vaccination uptake in a gynecologic oncology clinic.

  Recruiting University of Southern California · Los Angeles, California · NCT07279571

• Fixation versus arthroplasty for faster recovery after minimally displaced femoral neck fractures (FASTER-HIP)

  This trial will test whether replacing the hip (arthroplasty) instead of fixing the bone (internal fixation) helps people aged 60 and older with minimally displaced femoral neck fractures recover faster, stay alive and walking, and spend more days at home over the first year.

  Recruiting at 23 sites University of Southern California · Irvine, California and 31 other locations · NCT07244211

• Imiquimod cream for oral dysplasia

  This trial will test whether applying 5% imiquimod cream inside the mouth can shrink precancerous oral dysplasia and reduce abnormal cells in adults who cannot or do not want surgery.

  Recruiting Phase 1/2 University of Southern California · Los Angeles, California · NCT07210775

• How past alcohol or drug use affects detection and treatment of non-small cell lung cancer

  This project will talk with adults who have non-small cell lung cancer and a history of alcohol or drug use to see if those histories help or hinder getting detected and treated.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT07186699

• MRI-based machine learning versus radiologist reads to detect prostate cancer

  This trial tests whether MRI-based AI methods can find clinically significant prostate cancer as well as experienced radiologists in men getting a prostate biopsy or prostate removal surgery.

  Recruiting University of Southern California · Los Angeles, California · NCT07162194

• Transcranial magnetic stimulation combined with therapy for OCD

  This trial will test whether combining repetitive transcranial magnetic stimulation (rTMS) with either Exposure and Response Prevention (ERP) or supportive therapy helps adults with OCD.

  Recruiting University of Southern California · Los Angeles, California · NCT07146438

• Metformin XR to reduce hyperemesis gravidarum risk in people trying to conceive

  This study tests whether daily extended-release metformin taken before and early in pregnancy can lower the chance and severity of hyperemesis gravidarum in people ages 18–49 who have had HG before and are trying to conceive.

  Recruiting Phase 1/2 University of Southern California · Birmingham, Alabama and 1 other locations · NCT07129473

• Multimodal sensing and machine learning to detect mental and social states

  This project will test wearable skin sensors, a conversational virtual human, audiovisual emotion recognition, and machine-learning models to detect mental states in healthy adults and in adults with drug‑resistant epilepsy who already have intracranial EEG implants.

  Recruiting at 2 sites University of Southern California · Downey, California and 1 other locations · NCT07110688

• Breast cancer screening for women with moderate genetic or estimated lifetime risk

  This project will see if women aged 30–74 with certain moderate-risk gene variants or a 20–40% lifetime risk follow recommended annual breast MRI and mammogram screening.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT07076147

• Tirzepatide to help reduce drinking in adults with alcohol use disorder who are overweight

  This trial will test whether weekly tirzepatide injections help adults with alcohol use disorder and overweight or obesity drink less and improve heart and metabolic health compared with placebo.

  Recruiting Phase 2 University of Southern California · Los Angeles, California · NCT06994338

• Alzheimer’s Tau Platform: a Master Protocol

  This platform study tests tau-directed therapies, alone or with donanemab, in adults 50–80 with late preclinical or early prodromal Alzheimer’s disease to see if they reduce brain tau and slow disease progression.

  Recruiting at 7 sites Phase 2 University of Southern California · Phoenix, Arizona and 6 other locations · NCT06957418

• Sensory-adapted dental care with optional video modeling for children with dental fear

  This test will see if changing the sights and sounds in the dental room, with or without a short video model, helps reduce anxiety, pain, and discomfort during cleanings for children aged 6–12 with or without dental fear.

  Recruiting University of Southern California · Los Angeles, California · NCT06912854

• GPS tracking to support Hepatitis C treatment for people experiencing unsheltered homelessness.

  This trial tests whether giving GPS trackers to people with Hepatitis C who are living unsheltered and receiving street medicine helps them stick to their daily hepatitis C medication.

  Recruiting at 2 sites University of Southern California · Alhambra, California and 1 other locations · NCT06870019

• Comparing pneumatic compression and blood flow restriction for muscle recovery

  This study tests whether pneumatic compression or blood flow restriction helps young, active people recover better from muscle soreness after exercise.

  Recruiting University of Southern California · Los Angeles, California · NCT06815367

• Measuring how hearing devices change social engagement in older adults with hearing loss

  This project will try hearing devices to see if they change social activity, thinking, and brain signals in adults aged 60 and older with hearing loss.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06781749

• Telehealth BASICS for college students who drink heavily

  This study tests whether a telehealth version of BASICS can help college students who drink hazardously compare to in-person BASICS and usual treatment.

  Recruiting University of Southern California · Houston, Texas · NCT06774300

• Spanish-language support program for Latino family caregivers of people with dementia

  This project will test whether a three-session Spanish-language group class can reduce depression, anxiety, and caregiver burden for Spanish-speaking Latino family caregivers of people with dementia.

  Recruiting University of Southern California · Los Angeles, California · NCT06747637

• FEAST Perinatal Support Program for Pregnant and Postpartum People

  This program tries a community-based combination of dietary education, skills training, social support, and grocery gift cards for pregnant people on WIC/EBT to help them eat healthier and feel better during pregnancy and postpartum.

  Recruiting University of Southern California · Los Angeles, California · NCT06715787

• Long versus short Clomid protocols for ovarian stimulation in IVF

  This test compares taking Clomid throughout an IVF stimulation cycle versus the usual five-day Clomid course (with a GnRH antagonist) to see which approach yields more mature eggs for people with diminished ovarian reserve.

  Recruiting Phase 4 University of Southern California · Pasadena, California · NCT06701071

• Social influence on drinking among young adults

  This test will see if being around same-sex platonic friends changes how much young adults (21–28) drink during lab sessions and in daily life.

  Recruiting University of Southern California · Los Angeles, California · NCT06627803

• Examining how emotions affect physical activity engagement

  This study is trying out new ways to see if changing how people feel about exercise can help overweight or obese adults get more active.

  Recruiting University of Southern California · Los Angeles, California · NCT06570642

• Exploring the appeal and risks of oral nicotine products among young adult e-cigarette users

  This study looks at how appealing and risky new oral nicotine products are for young adults who only use e-cigarettes to see how flavors and nicotine levels affect their choices.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06506162

• Golf exercise program for prostate cancer survivors

  This study tests whether a 10-week golf exercise program can help prostate cancer survivors feel better physically and mentally.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06500169

• Lifestyle intervention to prevent diabetic foot ulcers from coming back

  This study tests a lifestyle program to help people who have healed diabetic foot ulcers take better care of their feet and manage their diabetes to prevent the ulcers from coming back.

  Recruiting at 2 sites University of Southern California · Downey, California and 2 other locations · NCT06487780

• Improving access to genetic testing for underserved cancer patients

  This study is testing whether a computer character can give better information about genetic testing to underserved cancer patients compared to regular human healthcare providers.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06422455

• Understanding head and neck cancer through detailed cellular analysis

  This study looks at the cells in head and neck cancer to see how they behave in patients with HPV-related throat cancer and their lymph nodes.

  Recruiting University of Southern California · Los Angeles, California · NCT06420219

• CarePair: a smartphone app that matches dementia family caregivers to services

  This six-week test tries to see if the CarePair mobile app helps family caregivers of people with dementia find needed services and feel less stressed.

  Recruiting University of Southern California · Los Angeles, California · NCT06418971

• Mindfulness practice to improve attention and memory in older adults

  This study tests if daily mindfulness exercises with heart rate feedback can help older adults improve their attention and memory over 10 weeks.

  Recruiting University of Southern California · Los Angeles, California · NCT06410157

• Understanding how to regulate emotions in depression

  This study is testing a new way to help young adults with depression and healthy volunteers learn to manage their emotions better by using biofeedback and comparing their experiences in daily life.

  Recruiting Phase 2 University of Southern California · Los Angeles, California · NCT06345859

• Evaluating the effectiveness of different bonding agents for dental sealants in children

  This study is testing whether dental sealants last longer when applied with a special type of glue in children’s mouths compared to a different kind of glue.

  Recruiting Phase 1 University of Southern California · Los Angeles, California · NCT06342258

• Evaluating blood tests for breast cancer diagnosis

  This study is testing a blood test for breast cancer to see if it works as well as traditional mammograms for diagnosing the disease.

  Recruiting at 4 sites University of Southern California · Los Angeles, California and 3 other locations · NCT06336928

• Combining botensilimab, balstilimab, a fasting mimicking diet, and vitamin C for KRAS-mutant metastatic colorectal cancer

  This study is testing if combining two new antibodies with a special diet and vitamin C can help people with KRAS-mutant metastatic colorectal cancer live longer and feel better.

  Recruiting at 3 sites Phase 1 University of Southern California · Fullerton, California and 2 other locations · NCT06336902

• Breast massage to reduce side effects in breast cancer patients after surgery

  This study tests whether breast massage can help women with breast cancer feel better and reduce side effects during and after radiation therapy.

  Recruiting University of Southern California · Los Angeles, California · NCT06297265

• Tailored lifestyle intervention for diabetic foot ulcer care

  This study is testing a new online program led by occupational therapists to help people with diabetic foot ulcers better manage their care and follow treatment plans over 8 weeks.

  Recruiting University of Southern California · Los Angeles, California · NCT06278935

• Mindfulness‑assisted Psilocybin Therapy

  This trial will test whether adding eight weeks of guided mindfulness classes to a single supervised dose of psilocybin improves mental health effects in healthy adults aged 25 and older.

  Recruiting Phase 2 University of Southern California · Los Angeles, California · NCT06233344

• Using contrast enhanced ultrasound to identify breast masses

  This study is testing if a special type of ultrasound with a contrast agent can help doctors tell the difference between harmless and harmful breast lumps to reduce unnecessary biopsies for patients with certain types of breast masses.

  Recruiting at 2 sites Phase 1 University of Southern California · Los Angeles, California and 1 other locations · NCT06171607

• Observational study of men with advanced prostate cancer

  This study is collecting blood, urine, and health information from men with advanced prostate cancer to help researchers learn more about the disease and improve future treatments.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06067295

• Understanding colorectal cancer in Hispanic patients

  This study looks at Hispanic patients with colorectal cancer to see how their genes and gut health affect their treatment and outcomes.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06063928

• Curcumin for treating inflammation and symptoms in blood disorders

  This study is testing if a curcumin supplement can help reduce inflammation and improve symptoms in people with certain blood disorders.

  Recruiting at 2 sites Phase 2 University of Southern California · Los Angeles, California and 1 other locations · NCT06063486

• Using blood tests to detect active testicular cancer

  This study is testing if a blood test can help find active testicular cancer earlier in patients before they have surgery.

  Recruiting at 7 sites University of Southern California · Birmingham, Alabama and 6 other locations · NCT06060873

• Engineered T cells for treating advanced triple negative breast cancer

  This study is testing a new treatment using specially engineered T cells to see if it can help people with advanced triple negative breast cancer that has come back or does not respond to other treatments.

  Recruiting Phase 1 University of Southern California · Los Angeles, California · NCT05989828

• Personalized self-management program to help colorectal cancer survivors adopt healthier habits

  This study will test whether a 6-week personalized self-management program helps colorectal and other gastrointestinal cancer survivors stick to healthy behavior recommendations better than a standardized program.

  Recruiting University of Southern California · Los Angeles, California and 1 other locations · NCT05984589

• How menstrual-cycle hormone changes affect response to eccentric leg exercise

  This project will test whether normal menstrual-cycle changes in estrogen and progesterone change how women feel before and after eccentric leg exercise and how quickly they recover.

  Recruiting University of Southern California · Los Angeles, California · NCT05934708

• Using air filtration to slow heart disease progression

  This study is testing if using air filters in homes can help slow down heart disease in adults who have had heart problems before.

  Recruiting University of Southern California · Los Angeles, California · NCT05867381

• Biorepository for breast cancer survivors

  This study is collecting blood samples and health information from women who have survived early to moderate stage breast cancer to help with future research on survivorship.

  Recruiting University of Southern California · Los Angeles, California · NCT05786664

• In-home intervention for infants at risk of cerebral palsy

  This study is testing whether a special in-home program that helps infants at risk of cerebral palsy practice standing and walking can improve their motor skills.

  Recruiting University of Southern California · Los Angeles, California · NCT05781438

• Evaluating the impact of zolpidem on recovery after lumbar spine fusion surgery

  This study is testing if giving a sleep aid called zolpidem to patients having spine surgery can help them recover better and feel less pain.

  Recruiting Phase 4 University of Southern California · Los Angeles, California · NCT05746143

• Improving heart and metabolic health with HEPA air purifiers

  This study is testing if using HEPA air purifiers can improve heart and metabolic health in non-diabetic adults aged 65 to 84 by reducing indoor air pollution.

  Recruiting University of Southern California · Los Angeles, California · NCT05718245

• Personalized electrical brain stimulation for epilepsy patients

  This study is testing a personalized brain stimulation method for epilepsy patients who don’t respond to medication, to see if it can better help manage their seizures and improve their mood.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT05327387

• Evaluating brain stimulation effects on cognition in Parkinson's Disease

  This study is testing if a new type of brain stimulation can improve thinking skills in people with Parkinson's Disease who already have a deep brain stimulator.

  Recruiting University of Southern California · Los Angeles, California · NCT05307055

• Using dextromethorphan to manage pain after knee surgery

  This study is testing if dextromethorphan can help reduce pain after knee surgery for people getting a total knee replacement.

  Recruiting University of Southern California · Los Angeles, California · NCT05278494

• Improving the hospital environment for preterm infants and their parents

  This study is testing a special program to see if it helps preterm infants and their parents feel better and bond more during their time in the NICU compared to regular care.

  Recruiting University of Southern California · St Louis, Missouri · NCT05230199

• Evaluating cefixime for treating syphilis

  This study is testing if cefixime can effectively treat early syphilis in patients, including those with HIV, as an alternative to the standard penicillin treatment.

  Recruiting Phase 3 University of Southern California · Los Angeles, California · NCT04958122

• Therapeutic exercise for shoulder pain relief

  This study tests whether specific exercises can help people with shoulder pain feel better and understand how these exercises work in the body.

  Recruiting University of Southern California · Los Angeles, California · NCT04923477

• Using danazol to treat blood cell deficiencies in patients with cirrhosis

  This study is testing if the medication danazol can help improve blood cell counts in people with cirrhosis who have low levels of red or white blood cells.

  Recruiting Phase 2 University of Southern California · Los Angeles, California · NCT04873102

• Improving music and speech perception for cochlear implant users

  This study is testing a new way to help cochlear implant users hear music and speech better by improving how they perceive sound details that are usually missed.

  Recruiting University of Southern California · Los Angeles, California · NCT04708717

• Using modified stent grafts to treat complex aortic aneurysms in frail patients

  This study is testing if specially designed stent grafts can safely help frail patients with complex aortic aneurysms instead of traditional surgery.

  Recruiting University of Southern California · Los Angeles, California · NCT04524247

• Using smart boots to improve adherence in diabetic foot ulcer treatment

  This study is testing whether different types of diabetic boots can help people with foot ulcers stick to their treatment and heal better.

  Recruiting at 4 sites Phase 2 University of Southern California · Downey, California and 3 other locations · NCT04460573

• Length of urinary catheter use after colorectal (pelvic) surgery

  This trial tests whether removing the urinary catheter on postoperative day 1 instead of day 3 is safe for adults having total mesorectal excision for rectal disease.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT04359069

• Combining Sarilumab with Capecitabine for Treating Triple Negative Breast Cancer

  This study is testing if combining an immunotherapy drug called sarilumab with a chemotherapy drug called capecitabine can help people with advanced triple negative breast cancer or those who still have high-risk disease after initial treatment.

  Recruiting at 2 sites Phase 1/2 University of Southern California · Los Angeles, California and 2 other locations · NCT04333706

• Observational cohort for adults with Down syndrome and Alzheimer's disease

  This study is trying to understand how thinking skills relate to Alzheimer's disease signs in adults with Down syndrome to help plan future treatments.

  Recruiting at 18 sites University of Southern California · Phoenix, Arizona and 21 other locations · NCT04165109

• Analyzing T-cell Repertoire in Acute Myeloid Leukemia Patients Undergoing Stem Cell Transplant

  This study is trying to see how the immune system's T-cells change in people with acute myeloid leukemia who are getting a stem cell transplant, by looking at blood samples before and after the procedure.

  Recruiting University of Southern California · Los Angeles, California · NCT03921047

• Low-dose radiotherapy for painful bone metastases in multiple myeloma patients

  This study is testing if low-dose radiation therapy can help reduce bone pain in patients with multiple myeloma that has spread to their bones.

  Recruiting at 9 sites University of Southern California · Duarte, California and 8 other locations · NCT03858205

• Web-based program to identify individuals at risk for Alzheimer's disease

  This study is testing a web-based program to find people at higher risk for Alzheimer's disease so they can be invited to join clinical trials for new treatments.

  Recruiting University of Southern California · San Diego, California · NCT03638583

• Genetic factors affecting liver damage from asparaginase in leukemia patients

  This study is testing how certain genes might affect the risk of liver damage from asparaginase in people newly diagnosed with acute lymphoblastic leukemia.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT03568266

• Using gentamicin to treat junctional epidermolysis bullosa

  This study is testing if a medication called gentamicin can help improve skin healing and condition in people with a rare skin disorder caused by specific gene mutations.

  Recruiting Phase 1/2 University of Southern California · Los Angeles, California · NCT03526159

• Collecting immune system samples from cancer patients, blood disorder patients, and healthy volunteers

  This study is collecting blood and tissue samples from cancer patients, blood disorder patients, and healthy volunteers to see how their immune systems respond to different treatments.

  Recruiting University of Southern California · Los Angeles, California · NCT03207854

• Collecting cancer-related data and samples for personalized medicine

  This study is collecting blood, tissue, and other samples from cancer patients and those at risk to see how this information can help create more personalized treatments for cancer.

  Recruiting University of Southern California · Los Angeles, California · NCT02970045

• Understanding cognitive decline in older adults with depression

  This study is trying to understand how depression affects thinking and memory in older adults by looking at brain scans and comparing them to people without depression.

  Recruiting University of Southern California · San Francisco, California and 1 other locations · NCT02434393

• Establishing a breast tumor tissue repository from core biopsies

  This study is creating a collection of breast tumor samples from patients with newly diagnosed breast cancer to help researchers learn more about the disease and improve treatments.

  Recruiting University of Southern California · Los Angeles, California · NCT02250352

NIH-funded research (newest 40 of 1056)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• RNA dysregulation in a rare childhood brain disorder (PCH1b)

  Researchers are studying a rare genetic brain disease in young children to understand how RNA processing goes wrong and leads to damage in the cerebellum and brainstem.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11617797

• Studying how diverse signals come from similar molecules at glutamatergic synapses

  A project at a university explores how synapses in the brain create different signals from a shared set of molecules, using a fruit-fly model to understand how this could relate to neurodevelopmental and neurodegenerative diseases.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11617112

• How brain chemicals may influence tau clumps in Alzheimer’s disease

  A study from USC explores how certain brain chemicals might influence the clumping of tau protein related to Alzheimer’s disease, aiming to identify factors that could affect disease progression.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11610160

• GLP-1 medicines and brain health: real-world clues about dementia risk

  A nationwide study will follow adults 21 and older using GLP-1 medicines to see how these drugs relate to memory, thinking, and dementia risk in real life.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11607813

• Male pesticide exposure and reproductive health through epigenetics

  This project looks at how a man’s exposure to pesticides might affect his fertility and the health of his future children through changes in DNA.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11606670

• Global effort to harmonize fMRI findings in psychiatry

  A large, international effort will standardize how brain MRI data are collected and analyzed in people with various mental health conditions to improve consistency and discovery.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11603614

• How our body’s cells accumulate mutations as we age

  A study to understand how normal body cells accumulate mutations over time, which may influence cancer risk and aging-related illnesses.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11599164

• Neutrophils and blood flow in vascular dementia and Alzheimer’s disease

  Researchers are studying how immune cells called neutrophils affect blood flow and brain inflammation in aging people with VCID and Alzheimer’s disease.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11597294

• Cirrhosis Patient Cohort Study at USC

  A large, multi-center study follows adults with compensated cirrhosis to better understand how the condition progresses and what factors influence outcomes.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11591410

• Better-TMD: Making Temromandibular Disorder Research Work for Patients

  A multi-site study partners with patients and caregivers to improve how we diagnose, characterize, and treat TMD in real life.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11585295

• A comprehensive school-based plan to reduce HIV stigma and abuse in boarding schools in Zambia

  A school-based program in Zambia aims to reduce HIV-related stigma and abuse among youth by implementing safeguarding practices.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11583785

• Improving access to memory care for dually eligible seniors

  This grant aims to understand and remove barriers that prevent low-income seniors, who qualify for both Medicare and Medicaid, from getting memory care for Alzheimer’s disease and related dementias.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11577302

• Open-Access HIV Care: Smart Tech for Detecting Drug Resistance and Guiding Treatment

  A patient‑focused project to speed up HIV drug resistance testing and tailor regimens using automated, AI-assisted technologies at open-access clinics.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11553170

• Father-inclusive parenting program to boost early child development

  A family-focused program tests whether including fathers in responsive parenting support leads to better outcomes for young children.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11552851

• Understanding barriers to using new Alzheimer's therapies for older adults

  This project studies what stops people 21 and older at risk for Alzheimer's from using new therapies and how those barriers affect health, daily life, and costs.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11537515

• How Education Might Shape Later-Life Dementia Risk

  This project looks at whether more or higher-quality education could lower the chances of developing Alzheimer's-related dementia later in life.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11529075

• Global Deep Learning effort to predict depression treatment response

  A patient-focused project uses AI on brain scans to predict who with major depression will respond to rTMS treatment.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11519980

• Detailed brain mapping for bipolar disorder and major depression

  Researchers are using thousands of MRI scans to map fine-grained brain structure differences in people with bipolar disorder and major depression compared with people without these conditions.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11512325

• Global brain imaging study to understand anorexia in teens and how it affects outcomes

  A large international study using brain scans to learn why anorexia nervosa develops, how it affects teens, and what predicts recovery or relapse.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11510576

• Improving Cancer Risk Scores Across Diverse Populations

  This project helps doctors and patients by refining polygenic risk scores so they work more accurately for people of different ancestries.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11509787

• How education shapes dementia risk across countries, generations, and sexes

  Looking at how different levels of education relate to dementia risk for adults across countries, birth cohorts, and between men and women.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11508133

• How education shapes dementia risk across countries, generations, and sexes

  Researchers will look at how different levels of schooling relate to Alzheimer’s and related dementias in people from different countries, birth cohorts, and men and women.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11508132

• How low blood flow after brain artery narrowing affects the vessel lining

  This work looks at whether areas of low blood flow downstream of narrowed brain arteries cause vessel lining damage and raise the chance of another stroke, for people with intracranial artery narrowing.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11504591

• Platelet markers and blood flow to predict recurrent stroke in intracranial artery disease

  Researchers will look at how a platelet protein (FcγRIIa) and blood flow patterns from CT angiography predict who might have another stroke after a minor stroke or TIA caused by intracranial artery disease.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11504575

• Understanding why Duchenne Muscular Dystrophy worsens and how to stop it

  A research team at USC is studying Duchenne muscular dystrophy to find out why the disease continues to progress and how to interrupt harmful changes in muscle tissue.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11502706

• Global effort to find brain and genetic markers of OCD

  This project combines brain scans and genetic information from people with OCD around the world to find biological patterns that help explain how OCD starts, changes, and responds to treatment.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11481349

• Genetics tools to study aging, behavior, and social factors in diverse groups

  A project to create user-friendly genetics tools that help researchers study aging, behavior, and social factors in diverse populations.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11476972

• How tiny ion channels shape inner-ear nerve function

  This project looks at how small electrical channels in inner-ear nerve cells control signals that help balance and hearing.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11473952

• How nuclear actin affects gene activity and aging

  Testing new ways to see tiny actin proteins inside cell nuclei to understand how they change gene activity during aging.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11472065

• Exercise and Muscle Factors that May Protect the Brain in Alzheimer's Disease

  A study from USC looks at how exercising muscles release signals that could help protect the brain from Alzheimer’s-related aging and pathology.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11472062

• Limiting tissue damage in necrotizing fasciitis by targeting tissue fat metabolism

  This project tests whether changing how tissues handle fats can protect skin and immune cells from damage during necrotizing fasciitis.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11466996

• Regulatory ideas to help young adults quit vaping in a simulated vape shop

  This project tests two policy ideas in a realistic fake vape shop to see if easier access to quitting aids and visible stop-smoking resources help young adults who want to quit vaping.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11464595

• Imaging tiny brain vessels to understand vascular dementia

  A doctor-scientist is testing a high-resolution brain MRI method to see tiny blood vessels and blood flow in people with vascular cognitive impairment and related dementias.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11463338

• Shape-based personalized imaging markers for Alzheimer’s disease

  Aims to create personalized brain imaging markers for Alzheimer’s disease by mapping where brain changes occur in individuals, with a focus on African American and Mexican American populations.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11463264

• Impact of brain-derived exosomes on Alzheimer’s disease biomarkers in older adults

  This project looks at tiny particles shed by brain cells in blood to see if they reveal early signs of Alzheimer’s and cognitive decline in older people.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11463254

• Reliable AI for MRI Image Reconstruction in brachial plexus care

  A new AI toolkit is being developed to reconstruct MRI images faster and more accurately for people with brachial plexus disorders.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11456899

• AI-guided design of nanoparticles to target organs safely

  A new AI-powered approach will predict how tiny drug carriers behave in the body to target specific organs more effectively and with fewer side effects.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11456868

• Housing and stress: how housing challenges affect heart health

  A small study will look at how not having stable, affordable housing affects stress and heart health for adults in the community.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11455173

• Understanding how postnatal growth plates stay healthy and grow bones

  This NIH grant explores how certain cell signals control the growth plates in children to help long bones grow properly.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11450981

• Dynamic cognitive health from everyday online surveys in dementia research

  A big study uses everyday online surveys to read how people’s thinking changes over time, with the goal of spotting early signs of dementia.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11450394

Quick answers

How many clinical trials run by University of Southern California are recruiting right now?

84, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (84 trials), Canada (2 trials), Spain (2 trials), United Kingdom (2 trials), Norway (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 1/2: 4, Phase 1: 4, Phase 4: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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