NIH-funded research U01 cooperative agreement

Better-TMD: Making Temromandibular Disorder Research Work for Patients

Official title: Broader Evaluation of TMD Treatment Efficacy and Response (BETTER TMD)

Funded at University of Southern California · NIH-11585295 · Data updated 2026-11-12

A multi-site study partners with patients and caregivers to improve how we diagnose, characterize, and treat TMD in real life.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionUniversity of Southern California
NIH-funded
Lab location1 site (Los Angeles, UNITED STATES)
Project startJuly 3, 2026
Project endJune 30, 2030
Funding year2026
Award (this year)$116,200
NIH project number3U01DE036113-02S1
Project IDNIH-11585295 on NIH RePORTER

Who could benefit from this research

Could help

Adults diagnosed with temporomandibular disorders who can participate in long-term, multi-site study activities and engage with patient advisory processes.

Less likely to help

Individuals not experiencing TMD or unable to participate in longitudinal, advisory-board activities may not benefit directly.

What this research studies

This project works with people who have TMD to shape how research is done, so studies fit real-life needs and reduce burden on participants. It will build a formal Patient & Community Advisory Board with the TMJ Association to guide study design, interpretation, and dissemination. The research aims to improve diagnosis, phenotyping, and treatment of TMD by integrating patient perspectives throughout implementation and analysis. By embedding patient voices, the project seeks to make findings more relevant and usable for patients and clinicians alike.

Why it matters

Potential benefit: If successful, patients with TMD could see faster, more patient-friendly research that translates into better diagnosis and treatment options.

How similar studies have gone: Engaging patients in research design has shown improvements in feasibility, recruitment, and relevance in other pain and chronic disease studies.

Where this research is happening

  • University of Southern California
    Los Angeles, United States
    Active

Researchers

  • Principal investigator: Chen, Jianfu — University of Southern California
  • Study coordinator: Chen, Jianfu

Related research

Other NIH-funded projects on the same topics.

  • RNA dysregulation in a rare childhood brain disorder (PCH1b)

    Researchers are studying a rare genetic brain disease in young children to understand how RNA processing goes wrong and leads to damage in the cerebellum and brainstem.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11617797

  • Studying how diverse signals come from similar molecules at glutamatergic synapses

    A project at a university explores how synapses in the brain create different signals from a shared set of molecules, using a fruit-fly model to understand how this could relate to neurodevelopmental and neurodegenerative diseases.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11617112

  • How brain chemicals may influence tau clumps in Alzheimer’s disease

    A study from USC explores how certain brain chemicals might influence the clumping of tau protein related to Alzheimer’s disease, aiming to identify factors that could affect disease progression.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11610160

  • GLP-1 medicines and brain health: real-world clues about dementia risk

    A nationwide study will follow adults 21 and older using GLP-1 medicines to see how these drugs relate to memory, thinking, and dementia risk in real life.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11607813

  • Male pesticide exposure and reproductive health through epigenetics

    This project looks at how a man’s exposure to pesticides might affect his fertility and the health of his future children through changes in DNA.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11606670

  • Global effort to harmonize fMRI findings in psychiatry

    A large, international effort will standardize how brain MRI data are collected and analyzed in people with various mental health conditions to improve consistency and discovery.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11603614

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.