Clinical trial Recruiting at 2 sites Observational Ages 18 and up

How past alcohol or drug use affects detection and treatment of non-small cell lung cancer

Official title: Qualitative Study on Detection and Treatment of Thoracic Malignancies in Patients With a History of Alcohol or Substance Use Disorder

Run by University of Southern California · NCT07186699 · Data updated 2026-11-12

This project will talk with adults who have non-small cell lung cancer and a history of alcohol or drug use to see if those histories help or hinder getting detected and treated.

More Lung Non-Small Cell Carcinoma trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment45 (estimated)
SponsorUniversity of Southern California
Academic / other
Drugs / interventionsradiation
Locations2 sites (Los Angeles, California and 1 other locations)
StatusRecruiting
StartedSeptember 29, 2025
Main results expectedSeptember 12, 2027
Study endsSeptember 12, 2028
Registry record updatedSeptember 22, 2026
Trial IDNCT07186699 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) with histologically confirmed non-small cell lung cancer who have received or are receiving curative-intent treatment and who had alcohol use or another substance use disorder within the past 10 years, and who speak English or Spanish, are ideal candidates.

Probably not a fit

Patients without a history of alcohol or non-tobacco substance use, those unable to maintain a 30–60 minute conversation due to cognitive impairment, and non-English/Spanish speakers are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational qualitative project will conduct semi-structured interviews (30–60 minutes) with adults diagnosed with non-small cell lung cancer who had alcohol or other substance use disorders in the prior 10 years, with optional follow-up focus groups to review preliminary findings. Participants will be recruited at Keck/USC, Los Angeles General Medical Center, and Norris Comprehensive Cancer Center and interviews will be conducted in English or Spanish. The aim is to identify social facilitators and barriers that affect timely detection and receipt of curative-intent treatment. Results will be used to inform outreach, care coordination, and possible interventions to improve access and outcomes for this population.

Why it matters

Potential benefit: If successful, the findings could guide changes in outreach, screening, and care coordination to improve timely detection and treatment for patients with histories of alcohol or substance use.

How similar studies have gone: Qualitative studies have previously identified social and structural barriers to cancer care, but focused research specifically on patients with alcohol or substance use histories in NSCLC is limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* \* Adults ≥ 18 years of age

  * Histopathologic or cytologic diagnosis of thoracic cancers, including lung and esophageal
  * Received or receiving curative intent treatment (e.g. surgery, radiation therapy, systemic therapy)
  * Ability to understand and the willingness to sign a written informed consent
  * English or Spanish speaking. Due to need to conduct semi-structured interviews which can develop into free-flowing conversations we need both participant and interviewer to be fluent

Exclusion Criteria:

* Patients with cognitive disability unable to maintain 30-60 minute conversation

Where it's running

  • Los Angeles General Medical Center
    Los Angeles, California, United States
    Recruiting
  • USC / Norris Comprehensive Cancer Center
    Los Angeles, California, United States
    Recruiting

Study contacts

  • Principal investigator: Brooks V Udelsman — University of Southern California

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.