Improving the hospital environment for preterm infants and their parents

Multisensory Interventions to Improve Neurodevelopmental Outcomes of Preterm Infants Hospitalized in the Neonatal Intensive Care Unit

Not applicable Interventional University of Southern California · NCT05230199

This study is testing a special program to see if it helps preterm infants and their parents feel better and bond more during their time in the NICU compared to regular care.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment215 (estimated)
Ages1 Day to 7 Days
SexAll
SponsorUniversity of Southern California Academic / other
Locations1 site (St Louis, Missouri)
Trial IDNCT05230199 on ClinicalTrials.gov

What this trial studies

This project aims to enhance the health and well-being of preterm infants and their parents through a structured multisensory intervention program called Supporting and Enhancing NICU Sensory Experiences (SENSE). The program includes specific doses and timing of interventions such as massage, auditory exposure, rocking, holding, and skin-to-skin care, tailored to the infant's developmental stage and medical status. Two-hundred fifteen parent-infant dyads will be enrolled within the first week of life and randomized to either the SENSE program or standard care during their NICU stay. Assessments of parent mental health, infant neurodevelopment, and parent-child interaction will be conducted at various intervals to evaluate the program's effectiveness.

Who should consider this trial

Good fit: Ideal candidates for this study are preterm infants born at or before 32 weeks gestation, along with their parents, who can participate within the first week of life.

Not a fit: Patients who are more than 32 weeks gestational age at birth or older than 7 days at the time of recruitment will not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly improve developmental outcomes for preterm infants and strengthen parent-child relationships.

How similar studies have performed: Previous studies have shown positive outcomes with multisensory interventions in NICUs, suggesting that this approach is promising and builds on established evidence.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* ≤ 32 weeks estimated gestational age (EGA)
* recruited within the first week of life

Exclusion Criteria:

* \> 32 weeks EGA at birth
* \>7 days old
* become wards of the state
* have a suspected or confirmed congenital anomaly
* face a high immediate threat of death, per the opinion of the attending physician.

Where this trial is running

St Louis, Missouri

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions PretermParent-Child RelationsParentsDevelopment, InfantSensory Integration Dysfunction
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.