Improving heart and metabolic health with HEPA air purifiers
Using Indoor Air Filtration to Reduce PM2.5 Cardiometabolic Effects in At-risk Individuals
This study is testing if using HEPA air purifiers can improve heart and metabolic health in non-diabetic adults aged 65 to 84 by reducing indoor air pollution.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 52 (estimated) |
| Ages | 65 Years to 84 Years |
| Sex | All |
| Sponsor | University of Southern California Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT05718245 on ClinicalTrials.gov |
What this trial studies
This randomized, double-blind, crossover trial aims to evaluate the effects of HEPA air purifiers on cardiometabolic health by reducing indoor PM2.5 exposure in non-diabetic adults aged 65 to 84. The study will involve 52 participants who will be block randomized into HEPA and control groups for 6-month interventions, followed by a wash-out period before switching groups. Researchers will conduct home visits to set up air purifiers, monitor air quality, and collect health data, including weight, blood pressure, and biospecimens. The study will assess changes in metabolic outcomes related to type 2 diabetes and explore the relationship between reduced PM2.5 exposure and these outcomes.
Who should consider this trial
Good fit: Ideal candidates are non-diabetic adults aged 65 to 84 years old with a history of overweight or obesity living in Los Angeles County.
Not a fit: Patients with a history of diabetes or significant health conditions that prevent participation will not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could lead to improved cardiometabolic health in older adults by reducing harmful air pollution exposure.
How similar studies have performed: Other studies have shown promising results in improving health outcomes through air quality interventions, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 65 and 84 years old; * Nonsmoker for at least 1 year; * History of BMI ≥ 25 kg/m2 in the past based on EMR information; * Either an English or Spanish speaker; * Live in the Los Angeles County. Exclusion Criteria: * History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia); * Currently have active cancer treatment; * The residential house has already had HEPA filters; * Participants will move out of the current house in the next 2 years; * Participants will spend more than one month living outside the primary home; * Have any health conditions that prohibit collecting health and covariate data and biospecimen; * The residential houses are not feasible for setting up air purifiers and air pollutants monitors; * Have high blood glucose from finger stick test (\> 200 mg/dL).
Where this trial is running
Los Angeles, California
- Keck School of Medicine, University of Southern California — Los Angeles, California, United States (Recruiting)
Study contacts
- Principal investigator: Zhanghua Chen, PhD — University of Southern California
- Study coordinator: Zhanghua Chen, PhD
- Email: zhanghuc@usc.edu
- Phone: 323-442-2109
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.