Improving heart and metabolic health with HEPA air purifiers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, crossover trial aims to evaluate the effects of HEPA air purifiers on cardiometabolic health by reducing indoor PM2.5 exposure in non-diabetic adults aged 65 to 84. The study will involve 52 participants who will be block randomized into HEPA and control groups for 6-month interventions, followed by a wash-out period before switching groups. Researchers will conduct home visits to set up air purifiers, monitor air quality, and collect health data, including weight, blood pressure, and biospecimens. The study will assess changes in metabolic outcomes related to type 2 diabetes and explore the relationship between reduced PM2.5 exposure and these outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 65 and 84 years old;
* Nonsmoker for at least 1 year;
* History of BMI ≥ 25 kg/m2 in the past based on EMR information;
* Either an English or Spanish speaker;
* Live in the Los Angeles County.

Exclusion Criteria:

* History of diabetes (both type 1 and type 2) or degenerative disease of the nervous system (Alzheimer's disease or dementia);
* Currently have active cancer treatment;
* The residential house has already had HEPA filters;
* Participants will move out of the current house in the next 2 years;
* Participants will spend more than one month living outside the primary home;
* Have any health conditions that prohibit collecting health and covariate data and biospecimen;
* The residential houses are not feasible for setting up air purifiers and air pollutants monitors;
* Have high blood glucose from finger stick test (\> 200 mg/dL).

Where it's running

• Keck School of Medicine, University of Southern California
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Zhanghua Chen, PhD — University of Southern California
• Study coordinator: Zhanghua Chen, PhD
• Email: zhanghuc@usc.edu
• Phone: 323-442-2109

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.