In-home intervention for infants at risk of cerebral palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the feasibility and initial effects of an intensive in-home standing and walking intervention for infants diagnosed with or at high risk of cerebral palsy (CP). Eight infants aged 5 to 12 months will participate in a structured program that includes an 8-week baseline period without intervention, followed by 16 weeks of intervention, and concluding with an 8-week follow-up period. The intervention involves parents implementing standing and walking practices with body-weight support to promote motor development during a critical growth phase. The goal is to optimize future walking outcomes for these infants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Infants with or at high risk of cerebral palsy (CP) who either:

  * have been diagnosed with CP by a medical professional, or
  * are at high risk of CP defined as having both:

    * clinical brain imaging indicating CP, such as (i) white matter injury (cystic periventricular leukomalacia or periventricular hemorrhagic infarctions), (ii) hypoxic-ischemic encephalopathy, or (iii) neonatal stroke, and
    * a score less than 63 or more than 5 asymmetries on the Hammersmith Infant Neurological Examination (HINE).

Exclusion Criteria:

* prenatal substance abuse,
* congenital malformations,
* drug-resistant epilepsy,
* visual impairment that hinders the infant from seeing toys,
* hearing impairment that hinders the infant from responding to sound,
* living in a location inaccessible by study personnel for in-home data collections,
* participant over 50 lbs in weight.

Where it's running

• University of Southern California
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: Barbara Sargent, PhD, PT — University of Southern California, Division of Biokinesiology and Physical Therapy
• Study coordinator: Barbara Sargent, PhD, PT
• Email: bsargent@pt.usc.edu
• Phone: 323-442-4823

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Spinal Stimulation During Walking to See If Spasticity Lessens in Cerebral Palsy

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• Smartphone gait checks for kids with unilateral spastic CP

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.