Understanding cognitive decline in older adults with depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the mechanisms behind cognitive impairment and accelerated cognitive decline in individuals suffering from Late Life Depression (LLD). It will enroll 120 participants, including those from a previous study and new participants, over a 30-month period. Participants will undergo various assessments, including MRI scans and PET imaging, to gather data on brain function and biomarkers. Additionally, data from 300 non-depressed individuals will be utilized for comparative analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1\. Individual participated in original Characterizing Cognitive Decline in Late Life Depression study or Multimodal MRI Characteristics of Psychotherapy Response in Late Life Depression Study.

Exclusion Exceptions:

1. Antidepressant medication treatment is allowed only if the medication dose is stable for 4 weeks prior to the MRI scan.
2. Psychotherapy interventions is allowed only if they have completed at least 4 weeks of individual or group psychotherapy intervention prior to the MRI scan.
3. Participants taking cognitive enhancing medications will be able to enter the study.

Where it's running

• University of California, San Francisco
  San Francisco, California, United States Recruiting
• University of Pittsburgh
  Pittsburgh, Pennsylvania, United States Completed

Study contacts

• Study coordinator: Nithya Ganesh
• Email: nithya.ganesh@ucsf.edu
• Phone: (415) 300-0582

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Can tACS modulate motivation and reward signals in cannabis use disorder and depression

  We’re testing whether a gentle brain stimulation method (tACS) can boost motivation and reward responses in adults with cannabis use and/or depression to see if it helps with anhedonia.

  Recruiting Florida State University · Tallahassee, Florida and 1 other locations · NCT07924852

• Neural links for real-world emotions in mood and anxiety

  Researchers are testing how real-life emotional moments relate to brain activity and stress responses in young adults with mood and anxiety symptoms, using smartphones, self-reports, tasks, and MRI.

  Recruiting University of Miami · Coral Gables, Florida · NCT07891624

• EEG-Guided TMS for Adults With Depression

  This study tests whether delivering intermittent theta burst stimulation (iTBS) timed to brain waves using EEG can improve treatment for adults with major depressive disorder who have not responded to usual antidepressants.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07862205

• iTBS to help anhedonia in depression (dual left DLPFC + OFC or left DLPFC alone)

  A brain stimulation study tests whether intermittent theta burst stimulation can help people with major depression who have anhedonia, using both dual-target (left DLPFC and OFC) and single-target (left DLPFC) approaches.

  Recruiting Central South University · Changsha, Hunan · NCT07813169

• One Day of Ultra-Accelerated TMS With a Dose of NRX-101 for Major Depression

  This study tests whether a single day of rapid TMS plus NRX-101 can help people with moderate to severe depression see improvement over six weeks.

  Recruiting Early Phase 1 Mclean Hospital · Belmont, Massachusetts · NCT07785102

• EEG microstates and inflammatory markers in treatment-resistant depression patients undergoing ECT

  This study tests how electroconvulsive therapy affects brain activity patterns seen in EEG and inflammatory biomarkers in adults with treatment-resistant major depression.

  Recruiting Istanbul University - Cerrahpasa · Istanbul, Bakırköy · NCT07748091

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.