Understanding head and neck cancer through detailed cellular analysis
An Integrative Multi-Omic Characterization of Head and Neck Carcinogenesis, Progression and Recurrence
This study looks at the cells in head and neck cancer to see how they behave in patients with HPV-related throat cancer and their lymph nodes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Southern California Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT06420219 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the high-resolution single-cell profiling of cancer-associated fibroblasts in patients with HPV-positive oropharyngeal squamous cell carcinoma and their metastatic lymph nodes. Participants will undergo photography, blood sample collection, and tissue collection, while their medical records will be reviewed to gather comprehensive data on the disease. The aim is to evaluate the cellular and biomarker characteristics associated with the aggressive behavior of head and neck cancer.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with a new diagnosis of head and neck cancer who have not received prior treatment.
Not a fit: Patients who have previously undergone treatment for head and neck cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment strategies for head and neck cancer.
How similar studies have performed: Other studies have shown promise in using multi-omic approaches to understand cancer biology, suggesting potential for success in this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis/disease status: New diagnosis of head and neck cancer * Allowable type and amount of prior therapy: No prior treatment * Age ≥ 18 years. * Ability to understand and the willingness to sign a written informed consent. Exclusion Criteria: * Patients who have had treatment of head and neck cancer
Where this trial is running
Los Angeles, California
- USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States (Recruiting)
Study contacts
- Principal investigator: Albert Y Han, MD — University of Southern California
- Study coordinator: Sandy Tran, MS
- Email: sandy.tran@med.usc.edu
- Phone: 323-865-0451
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.