Comparing pneumatic compression and blood flow restriction for muscle recovery
Official title: Comparing the Effects of Pneumatic Compression and Blood Flow Restriction Therapy on Muscle Recovery
Run by University of Southern California · NCT06815367 · Data updated 2026-11-12
This study tests whether pneumatic compression or blood flow restriction helps young, active people recover better from muscle soreness after exercise.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 30 Years |
| Sex | All |
| Enrollment | 33 (estimated) |
| Sponsor | University of Southern California Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | January 15, 2024 |
| Main results expected | December 1, 2025 |
| Study ends | May 1, 2026 |
| Registry record updated | March 30, 2026 |
| Trial ID | NCT06815367 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are recreationally active individuals aged 18-30 without any current musculoskeletal injuries.
✕Probably not a fit
Patients with conditions such as deep vein thrombosis, cancerous lesions, or those who routinely train for trail running may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effectiveness of two recovery methods, pneumatic compression and blood flow restriction (BFR), in reducing delayed onset muscle soreness (DOMS) following exercise-induced muscle damage. Participants aged 18-30 who are recreationally active will be enrolled to assess which method better enhances recovery. The pneumatic compression method mimics a massage by applying and releasing pressure on the limb, while BFR involves using pressurized cuffs to restrict blood flow. The goal is to determine which technique is more effective in alleviating symptoms of DOMS.
Why it matters
Potential benefit: If successful, this study could provide patients with effective recovery techniques to reduce muscle soreness after exercise.
How similar studies have gone: While both pneumatic compression and blood flow restriction have been used in recovery, this study aims to directly compare their effectiveness, making it a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-30 years of age * Recreationally active population * Women should be on a form of hormonal contraception. * No current musculoskeletal injuries or pathologies * Must answer "yes" to all PAR-Q questions. Exclusion Criteria: * Individuals that routinely train trail running * Discomfort when running * Deep vein thrombosis * Blood clots * Cancerous lesions * Sensory or mental impairment * Unstable fractures * Acute pulmonary edema * Acute thrombophlebitis * Acute congestive cardiac failure * Acute infections * Episodes of pulmonary embolism * Wounds, lesions, infection, or tumors * Bone fractures or dislocations * Increased venous and lymphatic return * Answers "no" to any of the PAR-Q screening questions
Where it's running
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University of Southern California
Los Angeles, California, United States Recruiting
Study contacts
- Study coordinator: Bailey McLagan, MS
- Email: mclagan@usc.edu
- Phone: 323-442-2498
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.