Clinical trial Recruiting at 1 site Interventional Ages 18 to 55

Therapeutic exercise for shoulder pain relief

Official title: Mechanisms of Exercise for Rotator Cuff Tendinopathy / Subacromial Pain Syndrome

Run by University of Southern California · NCT04923477 · Data updated 2026-11-12

This study tests whether specific exercises can help people with shoulder pain feel better and understand how these exercises work in the body.

Quick facts

Study typeInterventional
Ages18 Years to 55 Years
SexAll
Enrollment60 (estimated)
SponsorUniversity of Southern California
Academic / other
Locations1 site (Los Angeles, California)
StatusRecruiting
StartedJune 8, 2021
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedFebruary 3, 2026
Trial IDNCT04923477 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults aged 18 to 45 with a clinical diagnosis of rotator cuff tendinopathy and moderate pain levels.

Probably not a fit

Patients with prior shoulder surgeries or serious spinal and shoulder pathologies may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of therapeutic exercise for patients suffering from rotator cuff tendinopathy and subacromial pain syndrome. It aims to understand the underlying mechanisms of pain relief through brain imaging and identify predictors of positive responses to exercise. The research will focus on the relationship between biomechanical factors and pain-related issues in individuals with chronic shoulder pain. By optimizing exercise delivery, the study seeks to improve treatment outcomes for affected patients.

Why it matters

Potential benefit: If successful, this study could lead to more effective exercise-based treatments for individuals with chronic shoulder pain.

How similar studies have gone: Previous studies have shown positive outcomes with therapeutic exercise for similar conditions, but this study aims to explore novel mechanisms not extensively researched.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. the clinical diagnosis for RC tendinopathy will be made with positive 3 of 5 tests: Hawkins-Kennedy, Neer, painful arc, empty can, external rotation resistance test
2. pain ≥ 3/10 on a numeric pain rating scale
3. age: 18 - 45 years
4. Participant must read, sign and date the appropriate Informed consent document.
5. Participant BMI ≤ 30

Exclusion Criteria:

1. Insufficient ability to comprehend and complete the questionnaires,
2. Inability to attend sessions,
3. Prior surgery of shoulder, neck or thoracic spine,
4. Primary complaint of neck or thoracic pain,
5. Diagnosis of cervical spinal stenosis,
6. Any serious spinal and shoulder pathology: infections, arthrosis, rheumatic disorders, acute fractures, shoulder dislocation, osteoporosis, or tumors,
7. Central Nervous System involvement, to include hyperreflexia, sensory disturbances in the hand, intrinsic muscle wasting of the hands, unsteadiness during walking, nystagmus, loss of visual acuity, impaired sensation of the face, altered taste, the presence of pathological reflexes (i.e. positive Hoffman and/or Babinski reflexes,
8. two or more neurologic signs of nerve root compression to include myotomal weakness, positive muscle stretch reflex, and dermatomal sensory loss,
9. any shoulder or arm pain with cervical spine tests of Spurling's Test, cervical rotation to the ipsilateral side, or axial compression test, or
10. primary adhesive capsulitis defined by passive range of motion loss \>50% as compared bilaterally of shoulder external rotation, internal rotation, or elevation.
11. Has a device or other condition that is not safe for MRI, including pacemakers.

Where it's running

  • Clinical Biomechanics Orthopedic and Sports Outcomes Research Laboratory
    Los Angeles, California, United States
    Recruiting

Study contacts

  • Principal investigator: Lori A Michener, PT, ATC, PhD — University of Southern California
  • Study coordinator: Lori A Michener, PT, ATC, PhD
  • Email: lmichene@usc.edu
  • Phone: 323-224-5032

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.