Stroke Volume–Based Fluid Resuscitation in Acute Pancreatitis
Official title: Stroke volUme-baSed Fluid resusciTAtIoN in AP (SUSTAIN)
Run by University of Southern California · NCT07756476 · Data updated 2026-11-12
This trial tests whether adjusting IV fluids based on each patient’s stroke volume helps people with acute pancreatitis avoid fluid overload while staying well hydrated.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of Southern California Academic / other |
| Locations | 2 sites (Los Angeles, California and 1 other locations) |
| Status | Recruiting |
| Started | March 19, 2026 |
| Main results expected | March 19, 2028 |
| Study ends | September 19, 2028 |
| Registry record updated | August 10, 2026 |
| Trial ID | NCT07756476 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 with predicted moderate to severe acute pancreatitis within 24 hours of enrollment.
✕Probably not a fit
Patients with high risk of fluid-related adverse events or significant comorbidities that contraindicate aggressive fluid strategies may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The SUSTAIN trial is a multi-center randomized study that compares stroke volume–guided fluid dosing to standard fluid strategies in adults with moderate to severe acute pancreatitis. It builds on prior findings that aggressive hydration can cause fluid overload without clear benefit, by personalizing fluid needs using stroke volume measurements. Participants receive Lactated Ringer's solutions and are managed with dosing tailored to changes in stroke volume, aiming to optimize hemodynamics and outcomes. The trial seeks to determine if this individualized approach improves clinical course compared with conventional hydration. Enrollment targets adults 18 to 75 within 24 hours of enrollment and excludes patients with conditions that increase risk from fluid resuscitation.
Why it matters
Potential benefit: If successful, patients may experience better recovery with fewer complications from fluid overload.
How similar studies have gone: Previous trials suggest that a simple aggressive hydration approach can cause fluid overload without improving outcomes, supporting the need for tailored strategies; the stroke volume–based approach is a novel refinement that requires confirmation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients between the age of 18-75 * Predicted moderate and severe acute pancreatitis, which will be defined by the presence of SIRs, within 24 hours of enrollment Exclusion Criteria: * Patients with the inability to preform a straight leg raise (i.e amputation) * Patients with high risk of adverse event related to fluid resuscitation * NYHA Class \>= II Heart Failure * Child's B and C Cirrhosis * Dialysis Requirement * Clinical signs of hypervolemia, including pulmonary congestion (i.e dyspnea, pulmonary crackles on exam, interstitual edema on imaging) and ascites * Ages \<18 years old * Pregnant * Incarcerated * Unable to provide informed consent
Where it's running
-
University of Southern California
Los Angeles, California, United States Recruiting -
Ohio State University
Columbus, Ohio, United States Active not recruiting
Study contacts
- Study coordinator: James L Buxbaum, MD
- Email: jorge.zunigagomez@med.usc.edu
- Phone: 323 442 0876
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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This study is testing if monitoring bowel sounds can help doctors predict which patients with acute pancreatitis might develop severe complications.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.