Cirrhosis Patient Cohort Study at USC
Official title: USC Cirrhosis Clinical Center
Funded at University of Southern California · NIH-11591410 · Data updated 2026-11-12
A large, multi-center study follows adults with compensated cirrhosis to better understand how the condition progresses and what factors influence outcomes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 22, 2021 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $301,266 |
| NIH project number | 5U01DK130197-06 |
| Project ID | NIH-11591410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with compensated cirrhosis and clinically significant portal hypertension who are receiving care at participating centers.
✕Less likely to help
Patients without compensated cirrhosis or portal hypertension, or those not enrolled at participating centers, may not directly benefit.
What this research studies
This project builds a prospective group of about 2,000 adults with compensated cirrhosis and signs of portal hypertension to track how their health changes over time. Researchers will collect detailed clinical data, lifestyle information, labs, imaging, and a rich bank of biospecimens for future translational research. They will explore how genetic factors, such as PNPLA3, and treatments like statins relate to disease progression and response. The study aims to describe the natural history of compensated cirrhosis in a diverse, real-world population and refine risk prediction for decompensation.
Why it matters
Potential benefit: Findings could improve how clinicians monitor cirrhosis, tailor treatments, and identify patients who may benefit from new therapies like statins or targeted studies.
How similar studies have gone: Similar longitudinal cohorts have provided valuable insights into cirrhosis progression and treatment responses, supporting the potential success of this approach.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Terrault, Norah a. — University of Southern California
- Study coordinator: Terrault, Norah a.
Related research
Other NIH-funded projects on the same topics.
-
Statin therapy for people with compensated cirrhosis
A big, long-term study at a major university is looking at whether statins can help people with compensated cirrhosis live longer and feel better.
-
Liver Cirrhosis Network: Centers for Clinical Research
A multicenter study in people with cirrhosis from different causes (including HIV, NASH, and alcohol-related liver disease) to collect data and samples and test new ways to predict and monitor disease progression.
-
Outcomes in cirrhosis from different causes and the role of HIV and simvastatin
This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.
-
Liver Cirrhosis Network: Mayo Clinic's Clinical Research Center
A Mayo Clinic-led project will follow and help people with compensated cirrhosis, using data, imaging, and a big AI tool to predict when complications may happen and test whether a statin can improve outcomes.
-
Understanding how risk factors affect progression of cirrhosis and response to statins in patients with cirrhosis
This project follows people with cirrhosis to see what factors speed up their liver disease and whether statin medicines help prevent worsening.
-
Cirrhosis Network study to understand mortality and therapies
A large, multi-center study in people with cirrhosis to find better ways to predict deaths and test the potential of statins to prevent complications like liver cancer and liver failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.