Exploring the appeal and risks of oral nicotine products among young adult e-cigarette users

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the appeal and potential abuse liability of novel oral nicotine products (ONPs) among young adults who are current exclusive e-cigarette users. It focuses on understanding how factors such as flavor and nicotine concentration influence the use patterns of ONPs, particularly in the context of increasing regulatory restrictions on e-cigarettes. By examining these dynamics, the research aims to inform public health regulations that could mitigate the risks associated with dual use of e-cigarettes and ONPs. Participants will be young adults aged 21-25 who have been using e-cigarettes regularly and have never tried ONPs.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. aged 21-25 years
2. current exclusive EC user (defined as at least weekly use over the past 3 months) and recent nicotine use confirmed by positive urine test (\>1 semiquantitative Total Nicotine Equivalent; see below)
3. not currently using another tobacco/nicotine product (defined as no use in the past 6 months)
4. have never used any ONP (medicinal or nonmedicinal)
5. willing to try study provided ONPs.

Exclusion Criteria:

1. recent COVID-19+ (positive test in the past 30 days)
2. a recent COVID-19 hospitalization (past 3 months)
3. unstable or significant psychiatric conditions (past and stable conditions allowed)
4. history of cardiac event or distress within the past 3 months
5. currently pregnant (based on urine pregnancy test), planning to become pregnant, or breastfeeding.

Where it's running

• University of Southern California
  Los Angeles, California, United States Recruiting
• University of Southern California
  Los Angeles, California, United States Recruiting

Study contacts

• Principal investigator: John R Monterosso, PhD — University of Southern California
• Study coordinator: John R Monterosso, PhD
• Email: johnrmon@usc.edu
• Phone: 3107099322

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.