Using dextromethorphan to manage pain after knee surgery
A Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Perioperative Dextromethorphan Compared to Placebo for the Treatment of Postoperative Pain
NA · University of Southern California · NCT05278494
This study is testing if dextromethorphan can help reduce pain after knee surgery for people getting a total knee replacement.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 160 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Southern California (other) |
| Locations | 1 site (Los Angeles, California) |
| Trial ID | NCT05278494 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of dextromethorphan, an analgesic, in reducing postoperative pain in patients undergoing total knee arthroplasty. It is a randomized, placebo-controlled trial where participants will receive either dextromethorphan or a placebo before and after surgery. The primary goal is to determine if dextromethorphan can significantly alleviate pain compared to no treatment. The trial will involve 160 participants, equally divided between the treatment and placebo groups.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are scheduled for total knee arthroplasty and are classified as ASA classes I to III.
Not a fit: Patients with a BMI of 35 or higher, a history of opioid abuse, or those who have experienced intractable vomiting after previous surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new, effective option for managing postoperative pain in knee surgery patients.
How similar studies have performed: While there is preclinical evidence supporting the analgesic effects of dextromethorphan, this specific approach in postoperative pain management is relatively novel and has not been extensively tested in clinical settings.
Eligibility criteria
Show full inclusion / exclusion criteria
Main Inclusion Criteria: * Patients Age ≥18 planning to undergo total knee arthroplasty * ASA classes I - III Main Exclusion Criteria: * BMI ≥ 35 * History opioid abuse * History of intractable vomiting after previous surgery
Where this trial is running
Los Angeles, California
- Keck School of Medicine of USC — Los Angeles, California, United States (RECRUITING)
Study contacts
- Study coordinator: Pui Yan, MS
- Email: puiyan@med.usc.edu
- Phone: 323-442-6984
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Post-operative Pain