Using dextromethorphan to manage pain after knee surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of dextromethorphan, an analgesic, in reducing postoperative pain in patients undergoing total knee arthroplasty. It is a randomized, placebo-controlled trial where participants will receive either dextromethorphan or a placebo before and after surgery. The primary goal is to determine if dextromethorphan can significantly alleviate pain compared to no treatment. The trial will involve 160 participants, equally divided between the treatment and placebo groups.

Why it matters

Who can join: the full rules

Main Inclusion Criteria:

* Patients Age ≥18 planning to undergo total knee arthroplasty
* ASA classes I - III

Main Exclusion Criteria:

* BMI ≥ 35
* History opioid abuse
* History of intractable vomiting after previous surgery

Where it's running

• Keck School of Medicine of USC
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: Pui Yan, MS
• Email: puiyan@med.usc.edu
• Phone: 323-442-6984

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.