Understanding how to regulate emotions in depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the different subtypes of major depressive disorder by examining how individuals perceive their ability to regulate emotions and the physiological responses associated with these efforts. Participants, including young adults with remitted depression and healthy volunteers, will undergo ambulatory assessments of their emotional regulation strategies and physiological activity in daily life. The study also includes lab-based evaluations to explore neural and behavioral differences among subtypes. Participants will be randomly assigned to receive a biofeedback intervention aimed at improving emotional regulation or a control intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria for Participants with Remitted Depression:

1. Age 18-27.
2. Meeting criteria for lifetime major depressive disorder.
3. Currently meeting criteria for full remission (absence of clinically significant symptoms) for at least eight weeks, and having a Hamilton Depression Rating Scale score of less than or equal to 7.

Inclusion Criteria for Healthy Volunteer Participants:

1. Age 18-27.
2. No lifetime history of any psychiatric disorder.
3. No first-degree relatives with a mood disorder.

Exclusion Criteria (same for all participants):

1. Change in psychotropic medication use within the last 30 days
2. Autism spectrum disorder
3. Current eating disorder
4. Intellectual disability
5. Substance use disorder within the past 6 months
6. Contraindications for magnetic resonance imaging or electrocardiogram assessment (e.g., presence of metal in body, claustrophobia, cardiac device, pregnancy).

Where it's running

• University of Southern California
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: Umiemah Farrukh
• Email: carlab@usc.edu
• Phone: 2137404503

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.