Mindfulness practice to improve attention and memory in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of daily mindfulness practice combined with heart rate biofeedback on attention and memory in older adults. Participants will engage in breathing exercises that either increase or decrease heart rate oscillations over a 10-week period. The study aims to assess changes in cognitive function and blood biomarkers related to Alzheimer's disease. Participants will also provide blood and urine samples during campus visits to evaluate physiological changes.

Why it matters

Who can join: the full rules

Inclusion criteria

* Fluent in English
* Black/African-American or White/European-American
* Aged between 50-70 years old
* Non-pregnant and non-menstruating (for at least the past year)
* Have normal or corrected-to-normal vision and hearing
* Have reliable access to wifi
* Have an email account that you check regularly
* Have a phone that receives text messages
* Agree to provide blood and urine samples at two campus visits
* Agree to devote up to 50 minutes daily to this study for 10 weeks as well as attend two campus visits

Exclusion criteria

* Have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, arrhythmia, dyspnea)
* Have cognitive impairment
* Have regularly played Lumosity games in the past 6 months
* Have any conditions listed below that are not safe for MRI

  * \*Metal in any parts of your body
  * Claustrophobia
  * Have worked as a machinist, metal worker, or in any profession or hobby grinding metal?
  * Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body)
  * Cardiac pacemaker
  * Implanted cardiac defibrillator
  * Aneurysm clip or brain clip
  * Carotid artery vascular clamp
  * Neurostimulator
  * Insulin or infusion pump
  * Spinal fusion stimulator
  * Cochlear, otologic, ear tubes or ear implant
  * Prosthesis (eye/orbital, penile, etc.)
  * Implant held in place by a magnet
  * Heart valve prosthesis
  * Artificial limb or joint
  * Other implants in body or head
  * Electrodes (on body, head or brain)
  * Intravascular stents, filters
  * Shunt (spinal or intraventricular)
  * Vascular access port or catheters
  * IUD
  * Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI
  * Shrapnel, buckshot, or bullets
  * Tattooed eyeliner or eyebrows
  * Body piercing(s) that cannot be removed for MRI
  * Metal fragments (eye, head, ear, skin)
  * Internal pacing wires
  * Aortic clips
  * Metal or wire mesh implants
  * Wire sutures or surgical staples
  * Harrington rods (spine)
  * Bone/joint pin, screw, nail, wire, plate
  * Wig or toupee that cannot be removed for MRI
  * Hair implants that involve staples or metal
  * Hearing aid(s) that cannot be removed for MRI
  * Dentures or retainers that cannot be removed for MRI

Where it's running

• University of Southern California
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: Emotion & Cognition Lab Coordinator
• Email: matherlab@usc.edu
• Phone: 213-740-9543

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.