Platelet markers and blood flow to predict recurrent stroke in intracranial artery disease

Who could benefit from this research

What this research studies

This study will combine patient-specific imaging data with blood test results to create a personalized risk model for recurrent stroke after ICAD. It will measure FcγRIIa expression on platelets and use CTA-derived wall shear stress calculations to understand how these factors interact with anti-platelet therapy and platelet reactivity. The project plans to enroll about 250 adults with acute ischemia within 72 hours of onset across six sites with diverse populations, and follow them to assess recurrent events over time. The goal is to identify high-risk patients and inform precision prevention strategies.

Why it matters

Where this research is happening

• University of Southern California
  Los Angeles, United States Active

Researchers

• Principal investigator: Liebeskind, David Sigmund — University of Southern California
• Study coordinator: Liebeskind, David Sigmund

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.