Web-based program to identify individuals at risk for Alzheimer's disease
Official title: Alzheimer Prevention Trials (APT) Webstudy
Run by University of Southern California · NCT03638583 · Data updated 2026-11-12
This study is testing a web-based program to find people at higher risk for Alzheimer's disease so they can be invited to join clinical trials for new treatments.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 50 Years to 85 Years |
| Sex | All |
| Enrollment | 200000 (estimated) |
| Sponsor | University of Southern California Academic / other |
| Locations | 1 site (San Diego, California) |
| Status | Recruiting |
| Started | December 20, 2017 |
| Main results expected | April 30, 2026 |
| Study ends | April 30, 2026 |
| Registry record updated | July 16, 2025 |
| Trial ID | NCT03638583 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals aged 50 and older who show no signs of dementia and are willing to participate in remote cognitive testing.
✕Probably not a fit
Patients who already have a diagnosis of dementia will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The Alzheimer Prevention Trials (APT) Webstudy aims to enhance enrollment in Alzheimer's disease clinical trials by identifying individuals at higher risk for developing dementia. Participants will register online, complete cognitive tests, and provide demographic information. They will return quarterly for follow-up assessments, and based on their risk scores, some may be invited for in-person evaluations at clinical trial sites. This approach combines web-based assessments with biomarker testing to refine the selection of high-risk individuals for further studies.
Why it matters
Potential benefit: If successful, this study could lead to earlier identification and intervention for individuals at risk of developing Alzheimer's disease.
How similar studies have gone: Other studies have shown promise in using web-based assessments for cognitive health, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * male or female at least 50 years of age * no evidence of dementia * willing to participate in remote longitudinal cognitive testing and possible referral for biomarker assessment based on risk Exclusion Criteria: * N/A. Anyone can register for the APT Webstudy, however, only individuals identified using the risk algorithm will be referred for in-person biomarker assessments.
Where it's running
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Https://Www.Aptwebstudy.Org
San Diego, California, United States Recruiting
Study contacts
- Principal investigator: Paul Aisen, MD — USC Atri
- Study coordinator: APT Webstudy Team
- Email: info@aptwebstudy.org
- Phone: 858-877-3135
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.