Sponsor or institution
Clinical trials and research at University of Chicago
As of November 12, 2026, Find a Trial lists 146 clinical trials run by University of Chicago that are recruiting, at sites in 3 countries (most in United States (143), Nigeria (2), Azerbaijan (1)). 1 was first registered in the last 30 days. By phase: Phase 2 (20), Phase 1 (13), Phase 1/2 (8), Phase 4 (5). There are also 900 NIH-funded research projects at this institution, with $601.4 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 146Clinical trials
- 900NIH research projects
- 1New in 30 days
- 3Countries
Newest trials
All recruiting trials (146)
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PMOS and Sleep Apnea: A Pilot Look at Mitochondrial Function
In women with PMOS, this pilot study tests whether sleep apnea treatment with CPAP improves mitochondrial function in leg muscle tissue.
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Medial knee osteoarthritis: inside vs outside corticosteroid injection
This study tests whether injecting a steroid inside the knee joint leads to different pain results than injecting it on the outside of the knee in people with medial knee osteoarthritis.
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See if tirzepatide helps with lorlatinib-related weight gain in NSCLC patients
This study tests whether tirzepatide can reduce rapid weight gain in adults with non-small cell lung cancer who are already taking lorlatinib.
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Pain control after wrist/hand surgery using ketorolac and nerve block
This study tests whether a ketorolac plus acetaminophen pain plan with a regional nerve block can reduce opioid use after hand and wrist surgery.
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Gut microbiome and metabolomics after stereotactic radiosurgery
This study will see if the gut microbiome and blood metabolites change after stereotactic radiosurgery and whether those changes relate to adverse effects like radiation necrosis.
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Recovery Legal Care: a program to help firearm-injury patients through legal support
This trial tests a medical-legal partnership that connects legal help with hospital-based violence recovery to address social and economic risks for patients treated for firearm or other violent injuries.
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Transition Support for First-Episode Psychosis
A team-based program helps people experiencing their first psychotic episode move from hospital to outpatient care to see if they stay engaged and feel better.
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Total IV anesthesia vs spinal anesthesia for same-day discharge after knee replacement
This study tests whether using total intravenous anesthesia (TIVA) or spinal anesthesia helps adults have same-day discharge after a primary total knee replacement.
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Combination immunotherapy and radiotherapy in metastatic non-small cell lung cancer
This trial will test whether adding immunotherapy to radiotherapy helps people with metastatic non-small cell lung cancer who have progressed on prior immunotherapy.
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Breakthrough therapy for adults with type 1 diabetes and chronic kidney disease using Tegoprubart and transplanted islet cells
This study tests a combination of Tegoprubart and transplanted pancreatic islet cells to see if it can improve insulin production and blood sugar control in adults with brittle type 1 diabetes and chronic kidney disease.
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Gut health and hormonal breast cancer treatment: does your microbiome affect side effects?
This study tests whether the gut microbiome is linked to gastrointestinal side effects in people with HR+/HER2- breast cancer who are taking abemaciclib with hormone therapy.
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Early parent education to improve infant sleep
This trial will test whether sending sleep information and advice to expecting parents helps their babies sleep longer and have fewer sleep problems during the first 24 months.
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BIG payment for young people with HIV
This study tests whether giving a basic income to young adults living with HIV helps them stay in care and achieve viral suppression better than usual care alone.
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Outpatient Visits vs Telehealth for Postoperative Care After Minimally Invasive Gynecologic Surgery
This study tests whether postoperative telehealth follow-up is not worse than in-person visits for women after minimally invasive gynecologic surgery.
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Guided spiritual care sessions for adults with acute leukemia
This will test whether adding guided spiritual care sessions helps adults hospitalized for initial treatment of acute leukemia compared with standard inpatient spiritual care.
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Immunotherapy with NY-ESO-1 TCR dnTGFβRII cells for ovarian cancer and other advanced solid tumors
This trial tests a gene-modified T cell therapy, given with or without decitabine, in adults whose tumors express NY-ESO-1.
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Lactulose to Boost Immunotherapy in Cancer Patients
A small study will test whether adding lactulose can help immunotherapy work better for adults with advanced cancer.
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CommunityRx-Dpeer: peer-led support to help dementia caregivers connect with community resources
This program tests a peer navigator model to help dementia caregivers access personalized community resources and ongoing support over 12 months.
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Capivasertib plus venetoclax with low-intensity chemotherapy for adults with lymphoid acute leukemia or lymphoblastic lymphoma
This will see if adding capivasertib to venetoclax and a low‑intensity chemotherapy regimen helps adults with relapsed or refractory lymphoid acute leukemia or lymphoblastic lymphoma.
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Toripalimab plus standard treatment for HPV-positive throat cancer
This trial tests whether adding toripalimab to chemotherapy followed by surgery or lower-dose radiation can help adults with HPV16-positive, locoregionally advanced oropharyngeal (throat) cancer.
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Outcomes after immediate lymphatic reconstruction
This protocol will follow people having immediate lymphatic reconstruction during lymph node surgery to see if the procedure prevents lymphedema.
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Two immunotherapies after treatment for HPV-positive head and neck cancer
This study tests whether adding fianlimab to cemiplimab helps prevent recurrence in adults with HPV-positive head and neck cancer who have detectable residual disease after initial therapy.
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Partial pleurectomy to relieve symptoms from unresectable pleural mesothelioma.
The team will try a limited partial pleurectomy and decortication to reduce chest symptoms and improve quality of life for people with epithelioid pleural mesothelioma that cannot be completely removed.
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Culturally adapted suicide prevention for Black middle school students in Chicago
This pilot will try a culturally adapted Signs of Suicide program to see if it helps Black middle school students in Chicago recognize suicidal thoughts and get help.
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Using PSMA PET with MRI to watch for prostate cancer returning after focal therapy
We will try adding a PSMA PET scan to routine MRI follow-up to see if it finds prostate cancer coming back sooner in men who had focal (partial gland) therapy.
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Adaptive pre-surgery treatment for untreated HPV‑negative locoregional head and neck cancer
This trial will test whether giving volrustomig with paclitaxel and carboplatin before standard therapy can shrink tumors in adults with untreated, locally advanced HPV‑negative head and neck squamous cell carcinoma.
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Empagliflozin for people with calcium kidney stones
This trial will test whether taking empagliflozin for four weeks changes urine chemicals linked to stone formation in adults who've had calcium kidney stones.
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Comparing the standard tibial intramedullary nail with a micromotion tibial nail for unstable tibial fractures.
This trial will test whether a micromotion tibial nail helps adults with unstable tibial fractures heal faster and have fewer complications than a standard tibial nail.
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Smart knee implants and patient satisfaction after knee replacement
This study will see if smart knee implants that send recovery data can help people recover, stay satisfied, and reduce clinic visits after knee replacement.
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Predicting severe traumatic brain injury events
This study is testing a new computer method to see if it can predict serious brain injury events in patients before they happen, so doctors can act quickly to help prevent more damage.
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Personalized intervention for menopausal women at risk of dementia
This study is testing a new support program for middle-aged women going through menopause who are at higher risk for dementia to see if it helps them manage their worries and improve their well-being.
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Detecting infections in fractures around joint implants
This project will test whether routine blood tests, synovial fluid analysis, and extended joint and tissue cultures can find infections in adults who have fractures around hip or knee replacements and need surgery.
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Assessing diabetes risk in cirrhosis patients before and after liver transplant
This study is trying to find out what factors might lead to diabetes in adults with liver cirrhosis before and after they get a liver transplant.
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Potassium citrate effects on kidney handling of oxalate and citrate in adults
This project will test whether a single oral dose of potassium citrate changes how the kidneys handle oxalate and citrate in adults with and without calcium oxalate kidney stones.
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Obstructive sleep apnea and blood sugar control in adults with type 1 diabetes
This project will try nightly CPAP to see if treating obstructive sleep apnea improves blood sugar control in adults with type 1 diabetes who use an insulin pump and continuous glucose monitoring.
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Zanzalintinib with pembrolizumab and cetuximab for recurrent or metastatic head and neck squamous cell cancer
This trial tests whether adding the oral drug zanzalintinib to pembrolizumab and cetuximab is safe and finds the best dose for adults with recurrent or metastatic head and neck squamous cell cancer.
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Home stool blood test (FIT) versus colonoscopy for people with Lynch syndrome
This study will test whether a home stool blood test (FIT) can find colorectal cancer or advanced precancerous lesions as accurately as colonoscopy in people with Lynch syndrome who are due for surveillance.
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Employment program to support HIV care in young Black sexual minority men
This study is testing an employment program to see if it helps young Black sexual minority men improve their job skills and health while managing their HIV care.
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Routine screening and support for emotional health in adults with type 2 diabetes
This project will test whether routine screening for diabetes-related emotional distress plus brief clinic training helps adults with type 2 diabetes and A1C over 8% feel less distressed and manage their diabetes better.
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Microbiota augmentation to restore healthy gut bacteria in hospitalized liver patients
This trial will test whether giving defined groups of healthy gut bacteria is safe and can restore key gut metabolites in hospitalized adults with liver disease who have low fecal butyrate and deoxycholic acid.
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Web-based intervention for sexual health in young female cancer survivors
This study tests whether a web-based program can help young female cancer survivors improve their sexual health and well-being after treatment.
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Tobacco cessation program for community behavioral health sites in Chicago
This project will test a community-informed smoking cessation program to help adults who smoke and receive services at behavioral health organizations in Chicago.
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Exploring the relationship between gut health and long COVID symptoms
This study is trying to see if problems with gut health are linked to ongoing symptoms in people who have long COVID.
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Stopping prostate cancer hormone injections early in older men
This trial tests whether men aged 70 and older who have been on LHRH agonists for more than three years can safely stop the injections while being monitored with regular testosterone testing.
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Investigating gut bacteria in critically ill patients
This study looks at how a specific gut bacteria called Pseudomonas aeruginosa affects critically ill surgical patients to see if it plays a role in their health and survival.
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Program to help minority women manage urinary control symptoms
This study is trying out a new home program to help minority women manage urinary control issues and see if it works well for them.
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Improving child mental health in Azerbaijan through community interventions
This study is testing different support programs to see which combination can best improve the mental health of children aged 7-14 from low-income families in Azerbaijan.
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Nutrition and exercise during hospital induction for adults with Philadelphia chromosome–negative B‑ALL
This program will test whether guided nutrition and in-hospital exercise during induction therapy help adults with Philadelphia chromosome–negative B‑ALL keep muscle and limit excess body fat.
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Registry for Genicular Artery Embolization in Knee Osteoarthritis
This study is trying to see if a new procedure called genicular artery embolization can help reduce knee pain in adults with osteoarthritis who aren't able to have surgery.
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New approaches to help people quit smoking
This project tests a short, professionally made educational video to help adult smokers (at least 10 cigarettes per day) — especially Black and other racial/ethnic groups — understand varenicline and decide whether to try medication or quit smoking.
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Collecting samples from cardiac surgery patients
This study is collecting samples from children having heart surgery to help researchers learn more about heart diseases and improve treatments.
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Monitoring heart function in patients with brain injuries
This study looks at how heart function affects recovery in people with brain injuries by tracking their health data after they leave the hospital.
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Registry for prostate cancer ablation data
This study is creating a database to collect information from men with prostate cancer who are having ablation treatments to see how well these procedures work and what side effects they may cause.
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De-escalating treatment for ulcerative colitis when biopsies show no inflammation
This will see if people with ulcerative colitis whose biopsies show no inflammation can safely reduce or stop their medications without losing remission.
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Lenvatinib plus pembrolizumab for anal or rectal cancer that progressed after first treatment
This trial gives lenvatinib with pembrolizumab to people whose anorectal squamous cell cancer has spread or gotten worse after first-line chemotherapy or chemoradiation to see if the combination controls the cancer and is safe.
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Testing Fulvestrant with Lu-DOTATATE for Advanced Pancreatic Neuroendocrine Tumors
This study is testing if combining Fulvestrant with Lu-DOTATATE can help people with advanced pancreatic neuroendocrine tumors feel better and improve their treatment results.
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Ethyl chloride spray to ease pain from limb corticosteroid injections
This trial will see if spraying ethyl chloride or cold saline on the skin reduces pain and anxiety for adults getting their first corticosteroid injection in an arm or leg.
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Assessing outcomes of immediate lymphatic reconstruction to prevent lymphedema
This study is testing if a new surgery called immediate lymphatic reconstruction can help prevent lymphedema in people who have had lymph nodes removed.
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Nerve block for pain relief after knee surgery
This study is testing whether a new nerve block method can help people feel less pain after knee surgery for tibial plateau fractures compared to the usual numbing injection.
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Impact of 24-hour shifts on immune function in surgery residents
This study tests how working 24-hour shifts affects the immune system of surgery residents by looking at their blood samples and health data.
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Using bupivacaine to reduce pain after ureteroscopy for kidney stones
This study tests if using bupivacaine in the bladder after kidney stone surgery can help reduce pain and improve comfort for patients.
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Using a new technique to repair large paraesophageal hernias
This study is testing a new surgical method for fixing large paraesophageal hernias in older patients to see if it works better and lasts longer than traditional repairs.
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Dexmedetomidine and Caffeine for Pediatric MRI Recovery
This study tests whether adding caffeine to a sedation medicine can help children aged 3 to 12 recover faster and have fewer problems after getting an MRI.
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Using auricular acupressure to improve health before lung surgery
This study is testing whether auricular acupressure can help improve the health and well-being of people aged 50 and older who are getting ready for major lung surgery.
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Using genetic testing to improve pain management in cancer patients
This study tests whether genetic testing can help doctors choose the right opioid doses to better manage pain for adults with cancer.
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Semaglutide to lose weight and reduce body fat to help atrial fibrillation
This trial will see if adding semaglutide (a prescription weight-loss medicine) to usual care helps adults with obesity and atrial fibrillation have less severe AF or fewer recurrences after treatment.
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Patient outcome reporting to speed PTSD diagnosis and care on Chicago's South Side
This project will try using patient portal outreach plus screening during primary care visits to find and connect adults with PTSD at two Chicago community health centers.
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Improving HIV services for justice-involved Black men and other key populations
This study is testing two different support programs to see if they can help Black men, transgender individuals, and women who have been involved with the justice system get better access to HIV care and job services.
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Text messages to help sticking with oral chemotherapy in ALL and T-cell lymphoma
Researchers are testing whether sending high‑frequency text reminders helps teens and adults on oral mercaptopurine and methotrexate stick with their treatment.
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Exploring the link between kidney stones, insulin resistance, and inflammation
This study is trying to see if people with kidney stones have more belly fat and inflammation compared to healthy individuals, to better understand how these factors are linked.
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Educational program for bladder cancer patients undergoing surgery
This study is testing an educational program with videos for bladder cancer patients having surgery to see if it helps them manage side effects better, either on its own or with extra support from geriatric services.
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A program to empower community health workers to combat vaccine misinformation
This study is testing a program that helps community health workers from Hispanic backgrounds use their personal stories to fight vaccine misinformation and boost vaccination rates in their communities.
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Education and support program for African American patients with advanced kidney disease
This study is testing a 12-week education and support program for African American patients with advanced kidney disease to see if it helps them better manage their condition and plan for treatment.
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Mobile program to help young adults stop or cut down e-cigarette use
This project will try a smartphone program to help 18-26-year-olds who use e-cigarettes or both e-cigarettes and regular cigarettes quit or cut down.
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Bionic breast implant to restore touch and reduce chronic pain after mastectomy
This project will try a bionic breast implant that stimulates nerves to restore touch and reduce chronic pain for adults having bilateral mastectomy with two-stage (tissue expander) reconstruction.
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Prehabilitation program for frail adults undergoing thoracic surgery
This study is testing a prehabilitation program for frail adults scheduled for thoracic surgery to see if it helps them get stronger and recover better after their operation.
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Dietary intervention to improve outcomes after colorectal cancer surgery
This study tests if a special high-fiber, low-fat diet can help people with colorectal cancer have better outcomes after their surgery.
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Testing anti-HER2 treatment before and after surgery for Nigerian women with HER2+ breast cancer
This study will test whether giving anti-HER2 drugs with chemotherapy before and after surgery helps Nigerian women with HER2-positive breast cancer.
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Assessing outcomes of fat transfer for breast or chest wall reconstruction
This study is testing if using your own fat for breast or chest wall reconstruction can improve results and satisfaction for patients over time.
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Effects of hypoglossal nerve stimulation on glucose metabolism in obstructive sleep apnea
This study is testing if a treatment called hypoglossal nerve stimulation can help improve blood sugar levels and heart health in overweight or obese adults with obstructive sleep apnea who can't or don't want to use CPAP therapy.
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Combining Ivosidenib and Ruxolitinib for Advanced Myeloproliferative Neoplasms with IDH1 Mutation
This study is testing if combining two medications, ivosidenib and ruxolitinib, can help people with advanced myeloproliferative neoplasms that have an IDH1 mutation feel better and improve their treatment outcomes.
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Combination chemotherapy for Nigerian women with triple-negative breast cancer.
This will test whether epirubicin plus cyclophosphamide followed by docetaxel plus carboplatin leads to complete tumor disappearance at surgery and whether blood biomarkers can show chemotherapy resistance in Nigerian women with triple-negative breast cancer.
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Measuring uterine tone during cesarean delivery
This study is testing a new tool to measure the tightness of the uterus during scheduled cesarean deliveries to see if it gives more accurate results than the usual method.
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Evaluating hiatal closure for treating early GERD
This study is testing if a new surgical method called hiatal closure can help people with early GERD feel better by fixing the problem with their esophagus.
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Shortened radiation treatment for multiple myeloma
This study is testing if a shorter and stronger radiation treatment can safely help people with multiple myeloma feel better.
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A new approach to help young adults lose weight
This study is testing a new program that uses technology and coaching to help young adults aged 18 to 40 lose weight over six months.
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Evaluating oxygen levels in colon vascular lesions
This study is trying to see if the oxygen levels in the colon of people with certain blood vessel problems are different from those in healthy individuals.
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Shortening the trial time for sacral neuromodulation in treating urinary incontinence
This study is testing if cutting the trial period for a nerve treatment from 7 days to 3 days can still help women with urinary incontinence feel better before getting a permanent device.
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Evaluating frailty and side effects in older men with metastatic prostate cancer receiving hormone therapy
This study is trying to find out what makes older men with advanced prostate cancer feel weaker and have side effects while they are on hormone therapy.
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Investigating a new drug combination for relapsed acute lymphoblastic leukemia
This study is testing a new combination of drugs to see if it can safely help patients with relapsed acute lymphoblastic leukemia feel better and improve their treatment outcomes.
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Evaluating speech therapy for Primary Progressive Aphasia
This study is testing if speech therapy and a special app can help adults with mild to moderate Primary Progressive Aphasia communicate better.
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Using MRI to target radiation treatment in prostate cancer
This study is testing if using MRI can help target radiation treatment more precisely for men with prostate cancer, aiming to reduce damage to healthy tissue while hitting cancer spots harder.
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Improving care for individuals living with HIV through focused case management
This study is testing whether a new type of case management can help people living with or at risk for HIV improve their financial situation, access to food, and healthcare, compared to regular case management.
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Improving emergency evaluation and transfer protocols for stroke patients
This study is testing a new way to speed up the transfer of stroke patients to specialized hospitals to see if it helps them get better faster.
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Preventing Postoperative Atrial Fibrillation with Amiodarone
This study is testing if using a heart support patch along with a heart medication during surgery can help prevent irregular heartbeats in adults having heart surgery.
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Evaluating Astepro® Nasal Spray for Early COVID-19 Management
This study is testing if Astepro® nasal spray can help vaccinated adults with early COVID-19 by reducing the virus in their bodies compared to a placebo.
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Personalized treatment for advanced head and neck cancer
This study is testing if using blood tests to personalize treatment can help people with advanced head and neck cancer feel better and respond better to therapy.
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Using biomarkers and electronic scores to predict kidney injury in hospitalized patients
This study is testing if combining blood and urine tests with a new computer risk score can better predict which hospitalized patients are at high risk for serious kidney injury.
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Assessing walking ability in older adults before major surgery
This study is testing how well older adults can walk at home before major surgery to see if it can help predict their recovery afterwards.
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Canine-assisted therapy for youth with emotional and behavioral issues
This study is testing if a special dog therapy program can help young people in treatment centers with emotional and behavioral challenges feel better compared to standard treatment.
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Combining hormone therapy and focal ablation for prostate cancer treatment
This study is testing whether combining hormone therapy with focal ablation can help men with intermediate-risk prostate cancer have better treatment results.
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Combination treatment for relapsed multiple myeloma
This study is testing a new combination treatment for people with relapsed multiple myeloma who haven't had success with standard therapies to see if it helps them feel better.
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Dog training therapy program for youth with emotional and behavioral challenges
This study is testing a dog training therapy program to see if it helps young people with emotional and behavioral challenges feel better while they receive outpatient psychiatric care.
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Cooling therapy for pain relief after carpal tunnel surgery
This study is testing if a new cooling therapy can help people feel less pain after carpal tunnel surgery compared to regular ice packs.
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Combining Enzalutamide and Relacorilant for High-risk Localized Prostate Cancer
This study is testing whether combining two drugs, enzalutamide and relacorilant, with hormone therapy can help improve treatment outcomes for men with advanced, high-risk localized prostate cancer before surgery.
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Using social networks to improve HIV care for young Black men and women
This study is testing a new program that uses support from friends and family to help young Black men and women with HIV stay in care and manage their health better.
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Assessing Cardiac Function in Heart Failure Patients
This study is testing if a heart medication called milrinone can improve heart function and outcomes for people with heart failure who need advanced treatments.
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Understanding tissue damage and healing in celiac disease
This study is trying to understand how gluten and other factors affect tissue damage and healing in people with celiac disease, comparing those on a gluten-free diet to those who still eat gluten.
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Using tocilizumab to treat acute chest syndrome in sickle cell disease
This study is testing if a low dose of tocilizumab can help people with sickle cell disease who have acute chest syndrome feel better during their hospital stay.
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Combining radiation with experimental drugs for recurrent head and neck cancer
This study is testing a new combination of experimental drugs and radiation therapy to see if it can safely help people with recurrent head and neck cancer.
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Effect of ibuprofen on elevated PSA levels in men
This study is testing whether taking ibuprofen can lower high PSA levels in men who might need more tests for prostate issues.
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Using Pembrolizumab with Chemotherapy for Head and Neck Cancer
This study is testing if combining a blood test that checks tumor DNA with chemotherapy and immunotherapy can help people with head and neck cancer get better results than using immunotherapy alone.
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Understanding how oxalate affects kidney stone formation in bariatric surgery candidates
This study is testing how a low-oxalate diet affects kidney stone formation in people who are planning to have weight loss surgery and those who already have kidney stones.
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Effects of oxalate and citrate on kidney stone formation
This study tests how drinking a special beverage with oxalate affects kidney stone formation in people and whether diet plays a big role in this process.
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Using muscle assessment to predict health outcomes in liver disease patients
This study is testing if a quick muscle check during an MRI can help predict health outcomes for patients with liver disease.
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Consultation to reduce medication side effects using genetic information
This study is testing if a personalized clinic can help adults taking multiple medications by using their genetic information to reduce side effects and improve how their medicines work.
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Using muscle activity measurements to improve ALS diagnosis
This study is testing if a new way of measuring muscle activity can help doctors diagnose ALS more accurately and track how the disease changes over time.
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Combining durvalumab with radiation for extensive-stage small cell lung cancer
This study is testing if adding a new drug called durvalumab to radiation and chemotherapy can help people with extensive-stage small cell lung cancer live longer without their cancer getting worse.
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Finding HPV DNA in the blood of people with anal or cervical cancer.
This study will test whether a blood test can find HPV DNA in people with HPV-related anal or cervical cancer before, during, and after radiation treatment.
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Comparing different immobilization durations after thumb joint surgery
This study tests whether keeping the thumb in a cast for 2 weeks or 6 weeks after surgery helps people with thumb arthritis heal better and recover faster.
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Chemotherapy-free treatment for Ph+ Acute Lymphoblastic Leukemia using Inotuzumab Ozogamicin
This study is testing if adding a new drug called inotuzumab ozogamicin to standard treatment can help adults with newly diagnosed Ph+ acute lymphoblastic leukemia get better faster and more completely.
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Assessing the effects of spinal cord stimulators on diabetic neuropathy
This study is testing if spinal cord stimulators can help people with diabetes and painful nerve damage feel better and improve their overall health.
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Understanding how diet and sex affect kidney stone risk after bariatric surgery
This study tests how diet and gender affect the chances of getting kidney stones in people who have weight loss surgery.
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Using Olaparib for Patients with Malignant Mesothelioma and Genetic Mutations
This study is testing if the drug olaparib can help people with malignant mesothelioma who have certain genetic mutations by seeing if it can shrink their tumors.
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Improving care for disadvantaged Medicare patients to reduce hospitalizations
This study is testing three different ways to provide care for low-income Medicare patients at high risk of going to the hospital to see which one helps them stay healthier and happier.
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Using aspirin to reduce postpartum heart issues in women with preeclampsia
This study is testing if taking aspirin after childbirth can help women with preeclampsia and high Activin A levels have better heart function.
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Point-of-care test for current or past Toxoplasma gondii infection
This project will test a rapid point-of-care blood test to see if it can detect current or past Toxoplasma infection in adults, including pregnant people.
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Combining irinotecan with multiple chemotherapy agents for cancer treatment
This study is testing a new combination of chemotherapy drugs, including irinotecan, to see if it can safely help people with advanced gastrointestinal cancers like pancreatic and gastroesophageal junction adenocarcinoma who haven't had success with other treatments.
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Comparing how often to give nivolumab or pembrolizumab for advanced cancers
This study is testing if giving nivolumab or pembrolizumab less often can still help people with advanced cancers just as well as the usual schedule.
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Effects of heated chemotherapy on advanced gastric cancer
This study is testing if a special heated chemotherapy treatment can help people with advanced gastric cancer feel better by boosting their immune response more than regular chemotherapy.
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Comparing two methods for removing IVC filters
This study is testing two different ways to remove IVC filters to see which one works better and is quicker for patients who have had these filters for less than six months.
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Comparing two ventilation modes to reduce diaphragm atrophy in intubated patients
This study is testing if using a different breathing support method can help intubated patients avoid diaphragm problems and spend less time on a ventilator.
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Pharmacogenomic decision-making during elective surgery
This study is testing whether using genetic information from blood samples can help doctors choose the safest and most effective medications for adults having elective surgery.
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Program for monitoring women at high risk for breast cancer
This study is trying to see if regular MRI screenings can help women at high risk for breast cancer catch it early and improve their chances of staying healthy.
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Combining ruxolitinib with chemotherapy for young patients with Ph-like acute lymphoblastic leukemia
This study is testing if adding a drug called ruxolitinib to standard chemotherapy can help young patients with a specific type of leukemia feel better and improve their treatment results.
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Combining selumetinib and azacitidine for high-risk chronic blood cancers
This study is testing a new combination of two drugs, selumetinib and azacitidine, to see if it can help people with high-risk chronic blood cancers like chronic myeloid leukemia and myelofibrosis.
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Using pharmacogenomic information to improve warfarin dosing in African American patients
This study is testing if using genetic information can help doctors give the right dose of warfarin to African American patients in the hospital to improve their health outcomes.
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Frameless stereotactic radiosurgery for intact brain metastases
This trial will test whether omitting planning target volume (PTV) margins during frameless stereotactic radiosurgery changes progression-free survival in adults with 1–5 brain metastases.
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Comparing vasoactive drugs for treating shock in ICU patients
This study tests whether using phenylephrine and vasopressin can help ICU patients in shock feel better compared to the usual treatments of norepinephrine and epinephrine.
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Islet transplantation for patients with brittle Type 1 diabetes
This study is testing whether islet transplantation can help people with brittle Type 1 diabetes manage their blood sugar better without needing insulin shots.
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Collecting tissue samples from patients with various gastrointestinal cancers
This study is collecting tissue and blood samples from patients with different gastrointestinal cancers to help researchers learn more about these diseases.
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Studying how genetic testing can improve medication use in patients
This study is trying to see if using genetic testing can help doctors choose the right medications for patients with heart diseases, inflammatory bowel diseases, and autoimmune diseases to improve their treatment outcomes.
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Islet transplantation for better blood sugar control in type 1 diabetes after kidney transplant
This study tests whether getting islet cells from donors after a kidney transplant can help people with type 1 diabetes control their blood sugar better without needing insulin shots.
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Using lung tissues to study pulmonary fibrosis
This study looks at lung tissues from patients with pulmonary fibrosis to see what changes happen in the lungs and how it might help find new treatments for the disease.
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Observing the natural progression of interstitial lung disease
This study is collecting data and blood samples from people with interstitial lung disease to see how the condition progresses over time and to better understand its effects.
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Exploring the genetics behind heart and muscle diseases
This study is trying to find out how genetics play a role in heart and muscle diseases by looking at blood samples from families with these conditions.
NIH-funded research (newest 40 of 900)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Education and violence: Can high-dosage tutoring reduce youth violence
A large study in Chicago schools will test whether high-dosage tutoring for students can lessen youth violence by improving learning and outcomes.
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Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
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Lens proteins, cell stress, and cataracts in kids and adults
A study aims to understand how lens proteins and cellular stress contribute to cataracts, in both humans and mice, with the goal of guiding prevention or treatment.
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Understanding how neurons keep their identity and function for life
Scientists are studying how nerve cells maintain their distinctive identity and function from development through aging, using human-derived neurons and a simple worm model to uncover the long-term control of brain cell behavior.
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Cardiac Sarcomere Protein Quality Control in Health and Disease
A heart-focused study looking at how heart muscle proteins get misfolded and how the cell’s cleanup system might fix this to protect heart function.
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Communication Bridge: Improving language therapy for people with primary progressive aphasia
A proven language-therapy program called Communication Bridge helps people with primary progressive aphasia improve and maintain how they communicate with others.
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Intelligent and Personalized Online Adaptive Proton Therapy
A new, AI-powered online system aims to tailor proton therapy in real time for patients with cancers near vital organs, to reduce side effects and improve outcomes.
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Polyamine imbalance and nerve cell damage in Snyder-Robinson syndrome and related brain disorders
This NIH grant studies how faulty polyamine metabolism can contribute to brain damage and diseases like Alzheimer's, using fruit-fly models and patient cells to find ways to reduce neurotoxicity.
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Gut microbiome and Parkinson's disease: how gut bugs relate to symptoms and progression
A multi-year study will look at gut bacteria and related markers in people with Parkinson’s disease to understand how the gut-brain connection may influence symptoms and progression.
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BV-BRC: A powerful bioinformatics hub for deadly bacteria and viruses
A national resource is being expanded to give researchers easy access to expert biology tools and data to understand and fight infectious diseases.
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HEAL Data Platform to share addiction-related data across programs
A platform project to make HEAL data from many programs easier to find and use, helping researchers and clinicians access information about addiction in children and youth.
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Predicting head growth after craniosynostosis surgery in children
This project aims to better understand and forecast how a child's head grows after surgery for craniosynostosis to guide future treatments.
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Turmeric and ginseng use and heart health in Asian American adults
A one-year study will look at how common turmeric/curcumin and ginseng use relates to heart and metabolic health in Asian American adults.
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Glutaminase metabolism in dendritic cells and its role in inflammation and tolerance
This grant looks at how a key metabolic enzyme in dendritic cells may control whether immune cells promote inflammation or promote tolerance in allergic diseases.
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Connecting Black MSM with HIV Care: Modeling and Real-World Implementation
A patient-facing project using computer models to figure out better ways to link Black men who have sex with men to HIV care and keep them engaged.
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How the brain creates personal and world-centered maps to aid memory and navigation in people with Alzheimer’s disease
This NIH grant explores how the human brain builds egocentric (self-based) and allocentric (world-based) cognitive maps, using people with epilepsy for neural recordings to understand spatial memory related to Alzheimer’s disease.
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Genetic and brain-related roots of dad’s care behaviors
Researchers will study how genes and brain processes influence paternal care in small freshwater fish to understand why some dads help raise offspring.
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Improving treatment for people with HIV who smoke and drink in Nairobi, Kenya
A study tests a new plan to help people with HIV in Nairobi quit smoking and reduce heavy drinking, using a low-cost medicine and counseling.
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Center for Identification and Study of People with Atypical Diabetes
A research program at a major university aims to map and understand unusual forms of diabetes that don’t fit the common Type 1 or Type 2 categories, to improve diagnosis and care.
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Preventing organ rejection by targeting memory immune cells
Working to help people with organ transplants keep their new organs without lifelong immune-suppressing drugs by targeting stubborn memory immune cells.
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Illinois Precision Medicine Consortium: All of Us Site
A local All of Us site in Illinois is advancing precision health by expanding participant enrollment and integrating community and clinical efforts to support big-scale health research.
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Heterochronic model to understand birth defects in Down syndrome
A study at the University of Chicago will explore how having an extra chromosome 21 affects heart and brain development, aiming to uncover the causes of common birth defects in Down syndrome.
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Probiotics and vitamin D receptor in preterm infant gut health
A study to see if giving probiotics changes a key gut receptor (VDR) and supports healthy development in preterm babies.
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How DNA folding controls dendritic immune cells
Researchers are learning how the way DNA is folded inside dendritic immune cells affects their ability to make interferon and present foreign material to T cells.
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Understanding the immune cells that make antiviral interferon
Researchers are learning how a type of immune cell that makes antiviral interferon develops and acts, which could help people with viral infections or interferon‑linked autoimmune diseases.
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How cell-adhesion receptors help cells communicate and affect disease
This project is learning how two kinds of cell-surface 'communication' proteins (adhesion GPCRs and teneurins) work, which could help people with cancers and certain developmental or brain conditions.
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Tell me the truth about respiratory virus prevention in Chicago communities
A community-focused project in Chicago aims to share reliable, culturally relevant health messages about respiratory virus prevention through trusted local channels.
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Understanding how immune cells interact in celiac disease to guide healing
A study from the University of Chicago will follow people with celiac disease to understand how immune cells in the gut contribute to damage or healing when gluten is present or restricted.
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AI to predict melanoma coming back using tumor images, gene data, and pathology
This project is building an AI tool that uses detailed tumor pictures, gene activity, and pathology reports to help doctors predict whether early-stage (stage I or II) melanoma might return.
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Proton SBRT for refractory ventricular tachycardia with real-time 3D/4D imaging
A patient-facing study exploring a proton-based, noninvasive radiation therapy to treat stubborn VT using advanced 3D and 4D imaging to target the heart safely.
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Exploring understudied proteins as potential drug targets for adenoid cystic carcinoma
A small NIH grant is funding a patient-focused look at rare salivary gland cancer to find new proteins that could become targeted treatments.
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MIDRC Theranostics: Building a medical imaging data hub for burn-related theranostics
A large NIH data hub project aims to securely collect, harmonize, and share imaging and related data to support theranostics for burn injuries and related conditions.
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A new nasal vaccine idea to boost TB protection
A new mucosal vaccine approach using a Th17-focused immune strategy with a nasal nanoemulsion adjuvant aims to improve protection against tuberculosis for adults who are BCG-vaccinated or unvaccinated.
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Radio-triggered CAR-T cells to better control solid tumors
A new approach uses radiation to turn on and guide CAR-T cells to fight solid tumors more effectively, potentially improving local and distant tumor control for patients with cancer.
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Role of SASH3 in normal and malignant T cells
A study exploring how a protein called SASH3 helps T cells grow and survive, with a focus on relapsed T-ALL, to identify potential new ways to treat this deadly leukemia.
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Primary Care After Pregnancy: A New Way to Support Interconception Health
Aimed at improving the health of women after childbirth by testing a new primary-care–based model to deliver interconception care.
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Biophysical and structural clues on how T cells are selected in autoimmune disease
Aims to understand how self-reactive T cells are shaped in the body to prevent or cause autoimmunity, with potential to guide better treatments.
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Cnidarian hair-cell-like system reveals METC targeting in nematocytes
A small-scale NIH grant studies how a simple sea-creature’s sting cells may share key parts with human ear hair cells to understand how sound and movement are turned into signals.
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SplicingModulators to Target Hard-to-Drug Genes in Cancer and Neurodegeneration
A small set of compounds that adjust RNA splicing are being studied to turn off disease-driving genes that are hard to target with traditional drugs.
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Spatially-aware AI tools to map how cell states change inside tissue niches
A new AI-driven approach combines spatial and single-cell data to understand how cells change state within their tissue surroundings, with potential implications for cancer biology.
Quick answers
How many clinical trials run by University of Chicago are recruiting right now?
146, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (143 trials), Nigeria (2 trials), Azerbaijan (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 20, Phase 1: 13, Phase 1/2: 8, Phase 4: 5. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.