Understanding how diet and sex affect kidney stone risk after bariatric surgery
Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery
This study tests how diet and gender affect the chances of getting kidney stones in people who have weight loss surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 28 (estimated) |
| Ages | 18 Years to 130 Years |
| Sex | All |
| Sponsor | University of Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT04590690 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of diet and sex on the risk of developing kidney stones in individuals undergoing gastric bypass surgery. Participants will follow a specialized diet for six days and attend three study visits at the University of Chicago Medical Center. The research will analyze urine supersaturation levels and the correlation of gut microbiome species with urine oxalate levels. The study aims to identify sex differences in kidney stone risk among bariatric surgery candidates.
Who should consider this trial
Good fit: Ideal candidates are individuals approved for bariatric surgery without a history of kidney stones or renal impairment.
Not a fit: Patients with primary renal diseases, renal impairment, or known bladder voiding problems may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify dietary and biological factors that reduce the risk of kidney stones in bariatric surgery patients.
How similar studies have performed: Other studies have explored the relationship between diet and kidney stones, but this specific approach focusing on bariatric surgery candidates is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants without history of stone disease, family history of stone disease * Participants pre-bariatric surgery who are approved and planned for surgery in the Bariatric Surgery Center at University of Chicago Medicine. Exclusion Criteria: * Patients with primary renal diseases or renal impairment (eGFR \< 90) * Patients with known bladder voiding problems * Patients with 25-vitamine D deficiency, as defined by level \< 25ng/mL
Where this trial is running
Chicago, Illinois
- University of Chicago Medical Center — Chicago, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Prochaska Megan, MD — University of Chicago
- Study coordinator: Megan Prochaska
- Email: mprocha2@medicine.bsd.uchicago.edu
- Phone: (773) 702-1000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.