Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 and up

Pain control after wrist/hand surgery using ketorolac and nerve block

Official title: A Pilot Study to Assess Pain Control With Ketorolac and Nerve Block After Wrist and Hand Surgery

Run by University of Chicago · NCT07773155 · Data updated 2026-11-12

This study tests whether a ketorolac plus acetaminophen pain plan with a regional nerve block can reduce opioid use after hand and wrist surgery.

Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years and up
SexAll
Enrollment120 (estimated)
SponsorUniversity of Chicago
Academic / other
Locations1 site (Chicago, Illinois)
StatusRecruiting
StartedMarch 17, 2025
Main results expectedFebruary 2027
Study endsFebruary 2027
Registry record updatedAugust 19, 2026
Trial IDNCT07773155 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) undergoing hand or wrist surgery with regional nerve block at the University of Chicago.

Probably not a fit

Patients with contraindications to NSAIDs, chronic opioid use, or inability to avoid opioids may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized protocol compares two postoperative pain regimens in adults undergoing hand or wrist surgery with regional nerve block. Group A receives a nerve block plus 3 days of around-the-clock ketorolac and as-needed acetaminophen, aiming to avoid opioids. Group B receives the same nerve block plus a standard opioid regimen for three days. Participants report pain levels and medication use through surveys after surgery. The study uses FDA-approved medications as standard care components and is conducted at the University of Chicago.

Why it matters

Potential benefit: If successful, patients may experience better pain control with less or no opioid use after hand and wrist surgery.

How similar studies have gone: Previous research suggests multimodal nonopioid strategies can reduce opioid needs in some surgical settings, but this exact combination in hand/wrist surgery is being explored.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age 18 years or older
2. Undergoing upper extremity surgery performed by a hand and upper extremity orthopaedic surgeon at the University of Chicago.
3. Undergoing procedure with regional nerve block

Exclusion Criteria:

1. Age less than 18 years
2. Concomitant chronic opioid use
3. Postoperative opioid use (surgery through POD 14) for condition other than repaired fracture
4. Medical contraindication to ketorolac use, including pregnancy
5. Undergoing multiple concurrent surgical procedures
6. Unable to communicate numerical pain score

Where it's running

  • University of Chicago
    Chicago, Illinois, United States
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.