Mobile program to help young adults stop or cut down e-cigarette use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot interventional study develops and pilots an mHealth intervention that translates proven smoking-cessation content and medication guidance for young adult ENDS users, including dual users. Participants will be recruited at the University of Chicago and randomized to the EQUIP mobile program or to standard care, with enrollment focused on 18-26-year-olds who use ENDS frequently and want to quit or reduce. The protocol combines digital behavior-change tools, user feedback from focus groups, and optional pharmacotherapy information to refine the intervention. Primary outcomes will include feasibility, engagement, and preliminary changes in ENDS use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18-26 years old, ability to understand the English language, willing and able to provide informed consent
2. Current ENDS user (at least 4 out of 7 days per week of use for the past one month); for focus groups, at least half of participants will report current cigarette smoking (at least 1 cigarette per day on at least 1 day per week in the past month)
3. Report interest in quitting or reducing ENDS (at least 6/10 scale in interest of quitting or reducing
4. Does not currently (in past one year) meet criteria for major psychiatric disorder including severe alcohol or substance use disorder (excluding tobacco use disorder), schizophrenia, bipolar disorder, and obsessive compulsive disorder
5. For women, not currently pregnant, planning to become pregnant, or breastfeeding due to lack of information on ENDS use and possible harms from NRT during pregnancy
6. Not currently using smoking cessation medication (i.e., Varenicline, Bupropion
7. No history of adverse reactions to nicotine replacement therapy

Exclusion Criteria:

1. Does not own a mobile phone or is unwilling to receive text messages to their device
2. No interest in quitting or reducing use of ENDS
3. Uses electronic cigarettes less than 4 days per week in the past month
4. Reports past-year serious psychiatric illness, including severe alcohol or substance use disorder (excluding tobacco use disorder), schizophrenia, bipolar disorder, and obsessive compulsive disorder
5. Is currently using smoking cessation medication including Varenicline or Bupropion
6. Are a female who is currently pregnant or nursing or planning to become pregnant within the next 6 months

Where it's running

• University of Chicago BREATHE Laboratory
  Chicago, Illinois, United States Recruiting

Study contacts

• Study coordinator: Emma Brett, PhD
• Email: ebrett@bsd.uchicago.edu
• Phone: 773-834-5341

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.