Registry for Genicular Artery Embolization in Knee Osteoarthritis
Official title: Creation of a Prospective Data Collecting Registry for Genicular Artery Embolization for Arthritis (GAE)
Run by University of Chicago · NCT06781463 · Data updated 2026-11-12
This study is trying to see if a new procedure called genicular artery embolization can help reduce knee pain in adults with osteoarthritis who aren't able to have surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | October 1, 2023 |
| Main results expected | October 1, 2028 |
| Study ends | October 1, 2028 |
| Registry record updated | May 13, 2026 |
| Trial ID | NCT06781463 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with bilateral or unilateral knee pain due to osteoarthritis that has not improved with conservative medical management.
✕Probably not a fit
Patients with active malignancies, infections, or those who have had recent corticosteroid injections may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to create a prospective registry to evaluate the effectiveness of genicular artery embolization (GAE) in reducing knee pain associated with osteoarthritis. The registry will include patients aged 18 and older who have experienced knee pain for over six months and are not candidates for surgical knee replacement. The effectiveness of GAE will be measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and MRI will be utilized to assess knee remodeling post-procedure. The study will involve fewer than 100 patients and seeks to provide a comprehensive understanding of GAE's long-term benefits.
Why it matters
Potential benefit: If successful, this study could provide a minimally invasive alternative for patients suffering from knee osteoarthritis who do not respond to conventional treatments.
How similar studies have gone: Previous small cohort studies have shown significant pain reduction with genicular artery embolization, indicating potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged \>=18 * Bilateral or unilateral knee pain attributed to knee osteoarthritis (KOA). For bilateral KOA patients, the more severe knee will be permitted inclusion to the registry * Grade 1-3 Osteoarthritis as diagnosed on standing weight-bearing knee radiographs per the Kellen-Lawrence Grading scale * Knee pain \>6 months refractory to conservative medical management (Nonsteroidal anti-inflammatory drugs, acetaminophen, etc.) * Not eligible for surgical knee replacement or patient's personal preference to undergo Genicular Artery Embolization (GAE) for reasons such as minimally invasiveness of GAE Exclusion Criteria: * Active malignancy * Active infection of the affected knee * Platelets \<50,000/uL, INR \>2.0 (unless on anticoagulation that can be reversed or performing radial/pedal access without reversal) * Corticosteroid injection of the affected knee within 3 months of enrollment * Rheumatoid arthritis or other seronegative arthropathy * Previous surgery (excluding arthroscopy) of the affected knee * Grade 4 per Kellgren-Lawrence Grading Scale of the affected knee * Pregnancy or expected pregnancy * Glomerular Filtration Rate (GFR) \<30 * Anaphylactic reaction to iodinated contrast * Moderate to severe pain in other lower limb joints * Body weight \>400 lbs. (prohibiting safe angiography) * Peripheral arterial disease of the treated extremity (Rutherford Grade 2 or greater)
Where it's running
-
University of Chicago Duchossois Center for Advanced Medicine
Chicago, Illinois, United States Recruiting
Study contacts
- Study coordinator: Tiana Jackson
- Email: Tiana.Jackson@bsd.uchicago.edu
- Phone: 773.795.7030
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.