Assessing Cardiac Function in Heart Failure Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate whether differences in myocardial reserve can predict clinical outcomes in patients with heart failure. It is designed as a prospective, observational, crossover study that involves assessing invasive hemodynamics through right heart catheterization. Patients will be randomized to receive milrinone to determine its effects on cardiac function and outcomes. The study focuses on patients referred for advanced heart failure therapies or those with worsening clinical status requiring accurate hemodynamic assessment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. LVEF ≤ 40%
2. Referred for RHC for:

   1. Evaluation for advanced heart failure therapies, including LVAD, OHT, temporary or long-term inotrope therapy, or counter-pulsation (temporary or long-term with NuPulse device OR
   2. Accurate assessment of invasive hemodynamics due to worsening clinical status, OR
   3. Assessment of myocardial recovery for consideration of LVAD or counter-pulsation (temporary IABP or long-term with NuPulse device) decommissioning or removal OR
   4. Assessment of cardiac function and valvular abnormalities prior to planned valvular surgery for MR or AI
3. Estimated glomerular filtration rate (eGFR) ≥ 30 ml/min/1.73 m2
4. Age ≥ 18 years-old
5. Intent for admission based on RHC data

Exclusion Criteria:

1. eGFR \< 30 ml/min/1.73 m2
2. Severe, non-revascularized coronary artery disease
3. Concurrent acute coronary syndrome
4. Age \< 18 years-old
5. History of significant ventricular arrhythmia without an ICD

Where it's running

• The University of Chicago
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Valluvan Jeevanandam, MD — University of Chicago
• Study coordinator: David Onsager, MD
• Email: donsager1@uchgicagomedicine.org
• Phone: 7737021000

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Assessing muscle thickness changes in heart failure patients

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.